Contents
- 1 Finding Trials For Healthy Volunteers in Missouri
- 2 Where Clinical Research Opportunities Are Growing
- 3 A Maturing Population
- 4 Missouri CROs Seeking Healthy Volunteers for Progressing Clinical Research
- 5 Considerable Medical Breakthroughs in Missouri
- 6 Taking Advantage of Missouri’s Opportunities in Paid Clinical Trials
Finding Trials For Healthy Volunteers in Missouri
A lot of residents may not realize it, but there are ample opportunities in clinical research for paid clinical trials throughout Missouri. You can participate in important clinical research for money, help supplement your existing income, and play a real part in medical breakthroughs that could bring relief throughout the world. Our website provides regularly-updated data on available clinical studies across the state. There are quite a few to choose from; over a thousand of which are in Missouri.
Data indicates clinical trials require 1 out of 200 Americans to be involved nationally. A 2020 population census estimated Missouri’s total population at around 6.2 million. That has likely increased, as, in the last several years, many people have moved to new communities across the country; most notably in states like Missouri. There’s a need for existing medical infrastructure required to serve expanding population, and the potential for 31,000+ opportunities to participate in clinical trials (taking the statistics at face value). The facts bear this out. Organizations exist that have as an express goal the bettering of local health and economy in Missouri through medical advances; you can read more about that here.
Where Clinical Research Opportunities Are Growing
An indicator of the sort of CROs, or Clinical Research Organizations, that are conducting paid studies will in some ways be related to Missouri’s demographics. Age and ethnic background play a part in which studies are locally produced. To determine what clinical trial sponsors are most likely to have local studies, you need to know the state’s demographic makeup.
In Missouri, the 2020 census revealed Caucasians make up 61.6% of the population, with black communities comprising 12.4%, Hispanics at 18.7%, and Asians at 6%. Additional stats from ACL.gov (available in this .PDF) indicate that since 2010, over a third of the population is older than 50, more than 20% are over 60, 1 in 10 are over 70, and around 4% are over 80. Since over half the population has surpassed the age of fifty, you can expect many clinical trial sponsors to seek participants who fit this demographic.
We have compiled the following list of paid clinical trials for healthy volunteers, and click the Search All button at the bottom to find more:
International (Pediatric) Peritoneal Biobank
Recruiting
Within few years the peritoneal membrane of adult peritoneal dialysis (PD) patients undergoes substantial morphological transformation, including progressive fibrosis, vasculopathy and neoangiogenesis. Ultrafiltration capacity steadily declines and ultimately results in PD failure. In children, peritoneal biopsies demonstrating PD associated alterations have not yet been obtained. They, however, should be particularly informative, since secondary tissue and vascular pathology related to ageing o... Read More
Within few years the peritoneal membrane of adult peritoneal dialysis (PD) patients undergoes substantial morphological transformation, including progressive fibrosis, vasculopathy and neoangiogenesis. Ultrafiltration capacity steadily declines and ultimately results in PD failure. In children, peritoneal biopsies demonstrating PD associated alterations have not yet been obtained. They, however, should be particularly informative, since secondary tissue and vascular pathology related to ageing or diabetes is absent.
An international, prospective peritoneal membrane biopsy study in children on PD will therefore be performed. Biopsies will be obtained at time of PD catheter insertion, on occasion of intercurrent abdominal surgery (e.g. hernia repair, catheter exchange) and at time of renal transplantation. Quantitative histomorphometry and tissue protein expression analyses will be correlated with time integrated PD treatment modalities and functional characteristics as well as inflammatory and cardiovascular comorbidity surrogate parameter. Blood will be obtained during clinical routine sampling. Biopsies will be obtained during clinically indicated operations, without substantially increasing operation time and associated surgical risks. The detailed histomorphometry of the PD membrane will give additional information, potentially impacting on the individual PD regime.
3/2018: The analyses of the pediatric PD biopsy demonstrated early and major transformation of the peritoneal membrane with neutral pH low GDP fluids, and significant vasculopathy already in children with CKD stage 5, further progressing with PD. The underlying mechanisms are partly understood, only. In view of these major findings and the numerous open questions, collection of biosamples will be continued in children and also in adult PD patients. The following questions will be addressed: Molecular counterparts of peritoneal semi-permeability, solute and water transport (beyond AQP1), pathomechanisms and molecular and functional impact of peritoneal transformation with low and high GDP fluids, and the respective pathomechanisms and molecular and functional impact of vascular disease in CKD and with different PD fluids. The impact of renal transplantation following PD will be assessed in a subgroup of patients with tenckhoff catheter removal several weeks after transplantation and a functioning graft. Read Less
Gender:
ALL
Ages:
Between 1 day and 90 years
Trial Updated:
12/03/2024
Locations: Children's Mercy Hospital, Kansas City, Missouri
Children's Mercy Hospital, Kansas City, Missouri
Conditions: Kidney Failure, Chronic, Peritoneal Dialysis Complication, Transplantation, Healthy
Interhemispheric Connectivity and Compensation
Recruiting
The goal of this study is to determine which parts of the brain make it possible for some people to move skillfully with their left non-dominant hand.
The goal of this study is to determine which parts of the brain make it possible for some people to move skillfully with their left non-dominant hand. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Conditions: Peripheral Nerve Injury Upper Limb, Healthy
Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
Recruiting
The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.
The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system. Read Less
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
05/22/2025
Locations: University of Missouri, Columbia, Missouri
University of Missouri, Columbia, Missouri
Conditions: Obesity, Vasodilation, Healthy
Study to Assess the Safety, Tolerability, PK and PD of ABX1100
Recruiting
Study ABX1100-1001 is a first-in-human (FIH), phase 1 study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of a single ascending dose (SAD) and multiple doses (MD) of ABX1100 administered intravenously to healthy participants and patients with LOPD.
* Part A features a SAD study with a double-blind, placebo-controlled, randomized design in NHVs involving 3 cohorts (A1-A3). This Part also includes a single dose, open-labeled cohort (A4) in NHVs which will commence afte... Read More
Study ABX1100-1001 is a first-in-human (FIH), phase 1 study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of a single ascending dose (SAD) and multiple doses (MD) of ABX1100 administered intravenously to healthy participants and patients with LOPD.
* Part A features a SAD study with a double-blind, placebo-controlled, randomized design in NHVs involving 3 cohorts (A1-A3). This Part also includes a single dose, open-labeled cohort (A4) in NHVs which will commence after cohorts A1-3.
* Part B is a MD, double-blind, placebo-controlled, randomized design in NHVs. The MD Part B will commence after completion of Cohorts A1, A2 and A3 in the SAD Part A and SRC review of these 3 cohorts.
* Part C opened for enrollment after the Safety Review Committee (SRC) review of safety, PK and PD data from both Part A and Part B. Part C is a MD, open-label design in patients with Late-Onset Pompe Disease. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Washington University School of Medicine, St. Louis, Missouri
Washington University School of Medicine, St. Louis, Missouri
Conditions: Healthy, Late Onset Pompe Disease
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity
Recruiting
The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnormal obesity and lean individuals.
Both groups will have:
* screening visit
* imaging (body composition testing - dual-energy x-ray absorptiometry (DEXA) scans, magnetic resonance imaging \[MRI\] and... Read More
The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnormal obesity and lean individuals.
Both groups will have:
* screening visit
* imaging (body composition testing - dual-energy x-ray absorptiometry (DEXA) scans, magnetic resonance imaging \[MRI\] and magnetic resonance spectroscopy \[MRS\] scans)
* Overnight visit with intravenous infusion (IV), muscle, and fat tissue biopsies Participants with obesity will complete meetings with study team members for a weight loss intervention to achieve a 10% body weight loss. Read Less
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/16/2025
Locations: University of Missouri School of Medicine, Columbia, Missouri
University of Missouri School of Medicine, Columbia, Missouri
Conditions: Obesity, Nonalcoholic Fatty Liver, Diabetes Type 2, Healthy
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)
Recruiting
The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnormal obesity and lean individuals.
Both groups will have:
* screening visit
* imaging (body composition testing - dual-energy x-ray absorptiometry (DEXA) scans, magnetic resonance imaging \[MRI\] and... Read More
The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnormal obesity and lean individuals.
Both groups will have:
* screening visit
* imaging (body composition testing - dual-energy x-ray absorptiometry (DEXA) scans, magnetic resonance imaging \[MRI\] and magnetic resonance spectroscopy \[MRS\] scans)
* Overnight visit with intravenous infusion (IV), muscle, and fat tissue biopsies Read Less
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/16/2025
Locations: University of Missouri School of Medicine, Columbia, Missouri
University of Missouri School of Medicine, Columbia, Missouri
Conditions: Obesity, Non-Alcoholic Fatty Liver Disease, Diabetes Mellitus, Type 2, Healthy
Growth Hormone Resistance of Beta-cells
Recruiting
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a personal history of gestational diabetes (high blood sugar in pregnancy) at the University of Missouri. The aim of the study is to advance understanding of how growth hormone affects beta-cells and risk factors for developing gestational diabetes and type 2 diabetes.
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a personal history of gestational diabetes (high blood sugar in pregnancy) at the University of Missouri. The aim of the study is to advance understanding of how growth hormone affects beta-cells and risk factors for developing gestational diabetes and type 2 diabetes. Read Less
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
07/16/2025
Locations: University of Missouri School of Medicine, Columbia, Missouri
University of Missouri School of Medicine, Columbia, Missouri
Conditions: Gestational Diabetes, Obesity, Healthy
Growth Hormone Resistance of Beta-cells in Women and People
Recruiting
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a family history of type 2 diabetes at the University of Missouri. Our aim is to advance understanding of how growth hormone affects beta-cells and risk factors for developing gestational diabetes and type 2 diabetes.
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a family history of type 2 diabetes at the University of Missouri. Our aim is to advance understanding of how growth hormone affects beta-cells and risk factors for developing gestational diabetes and type 2 diabetes. Read Less
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
07/16/2025
Locations: University of Missouri School of Medicine, Columbia, Missouri
University of Missouri School of Medicine, Columbia, Missouri
Conditions: Healthy, Obesity
A Study of LY3537031 in Overweight, Obese, and Healthy Participants
Recruiting
This is a 4-part study that includes a Part A, Part B, Part C, and Part D. Parts A and D will study the safety and tolerability of the study drug known as LY3537031 in participants who are overweight and obese. Part B and Part C will study the safety and tolerability of LY3537031 in healthy participants. Part C will contain only Japanese and Chinese healthy participants.
Blood tests will be performed to check how much LY3537031 gets into the bloodstream and how long it takes the body to elimina... Read More
This is a 4-part study that includes a Part A, Part B, Part C, and Part D. Parts A and D will study the safety and tolerability of the study drug known as LY3537031 in participants who are overweight and obese. Part B and Part C will study the safety and tolerability of LY3537031 in healthy participants. Part C will contain only Japanese and Chinese healthy participants.
Blood tests will be performed to check how much LY3537031 gets into the bloodstream and how long it takes the body to eliminate it. Body weight will be measured. The study will last approximately 48 weeks excluding a screening period. Read Less
Gender:
ALL
Ages:
Between 22 years and 65 years
Trial Updated:
07/14/2025
Locations: QPS, Springfield, Missouri
QPS, Springfield, Missouri
Conditions: Healthy, Obesity
A Study to Evaluate Safety, Tolerability, and Immunogenicity of V350A and V350B in Healthy Participants (V350-001).
Recruiting
Epstein Barr virus (EBV) is a virus which can cause infectious mononucleosis and is associated with certain kinds of cancer and multiple sclerosis. Researchers are looking for new ways to prevent disease related to EBV and have developed a new study vaccine (V350A and V350B). The main goal of this study is to learn about the safety and tolerability of V350A and V350B in healthy adults.
Epstein Barr virus (EBV) is a virus which can cause infectious mononucleosis and is associated with certain kinds of cancer and multiple sclerosis. Researchers are looking for new ways to prevent disease related to EBV and have developed a new study vaccine (V350A and V350B). The main goal of this study is to learn about the safety and tolerability of V350A and V350B in healthy adults. Read Less
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
07/30/2025
Locations: Alliance for Multispecialty Research, LLC ( Site 0008), Kansas City, Missouri +1 locations
Alliance for Multispecialty Research, LLC ( Site 0008), Kansas City, Missouri
Bio-Kinetic Clinical Applications, LLC dba QPS-MO ( Site 0016), Springfield, Missouri
Conditions: Healthy
A Maturing Population
With an elderly population primarily Caucasian, the preponderance of medical research will involve conditions related to aging and ethnically-centered medical issues. Paid research will require healthy volunteers among the 60%+ of the population that is more mature, which is good news regarding income supplementation.
Many seniors are on a fixed income. With medical research studies, they can take full advantage of opportunities in paid clinical trials for healthy volunteers. They can help advance medicine and expand their own resources simultaneously.
Missouri CROs Seeking Healthy Volunteers for Progressing Clinical Research
All these things are good in theory, but where can you start looking for such opportunities? Here is a link to healthcare providers and CROs who may have just the opportunities you’re looking for; these include, among others:
- Washington University School of Medicine, St. Louis, Alzheimer’s Study
- Siteman Cancer Center, Coeur, MO, Carcinoma Study
- Altasciences, Kansas City, Coronary Syndrome Study
Considerable Medical Breakthroughs in Missouri
Already in Missouri, quite a few different medical discoveries have been made. Consider these:
- Missouri Has Added Breakthrough Data to COVID Studies
- The University of Missouri Continuously Seeks Medical Breakthroughs
- Over a Hundred Years of Innovation Provide a Strong Medical Foundation
Taking Advantage of Missouri’s Opportunities in Paid Clinical Trials
The bottom line of paid clinical trial opportunities in Missouri is this: there are diverse opportunities to explore throughout the state. If you’ve got the time and inclination, there’s a trial waiting for you somewhere. For trials that could be closer to you in the state of Missouri, review our listing pages for Kansas City and St. Louis.