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Innovation in Delaware is happening every day in the field of medicine. The state is home to world-class research institutions, including the University of Delaware and the Nemours Children’s Hospital.
You too can be a part of transformative discoveries that can reshape the future of healthcare.
Clinical Trials For Disease Areas in Delaware
DE research communities specialize in many areas. That includes pediatric medicine, cancer research, cardiology, and public health initiatives. Clinical research trials in Delaware explore new approaches for disease treatment, diagnosis, and prevention through exceptional studies.
In 2022, NIH (National Institutes of Health) awarded $10.9 million to experts from the Nemours Children’s Health organization. They were awarded the COBRE grant for their multidisciplinary approach, innovation, and technology for whole-person care.
If you or your organization want to take part in clinical trials in the state of Delaware, browse the list below.
Prospective Database Registry Study of Scoliosis in Children With Cerebral Palsy
Recruiting
The purpose of this study is to determine the radiographic and clinical outcomes of Scoliosis surgical and non-operative treatment in patients with Cerebral Palsy.
The purpose of this study is to determine the radiographic and clinical outcomes of Scoliosis surgical and non-operative treatment in patients with Cerebral Palsy. Read Less
Gender:
ALL
Ages:
Between 8 years and 21 years
Trial Updated:
11/20/2023
Locations: A.I. Dupont Hospital for Children, Wilmington, Delaware
A.I. Dupont Hospital for Children, Wilmington, Delaware
Conditions: Cerebral Palsy, Scoliosis
Left Ventricular Structural Predictors of Sudden Cardiac Death
Recruiting
Sudden cardiac death (SCD) poses a significant health care challenge with high annual incidence and low survival rates. Implantable cardioverter defibrillators (ICDs) prevent SCD in patients with poor heart function. However, the critical survival benefit afforded by the devices is accompanied by short and long-term complications and a high economic burden. Moreover, in using current practice guidelines of reduced heart function, specifically left ventricular ejection fraction (LVEF)≤35%, as the... Read More
Sudden cardiac death (SCD) poses a significant health care challenge with high annual incidence and low survival rates. Implantable cardioverter defibrillators (ICDs) prevent SCD in patients with poor heart function. However, the critical survival benefit afforded by the devices is accompanied by short and long-term complications and a high economic burden. Moreover, in using current practice guidelines of reduced heart function, specifically left ventricular ejection fraction (LVEF)≤35%, as the main determining factor for patient selection, only a minority of patients actually benefit from ICD therapy (\<25% in 5 years). There is an essential need for more robust diagnostic approaches to SCD risk stratification.
This project examines the hypothesis that structural abnormalities of the heart itself, above and beyond global LV dysfunction, are important predictors of SCD risk since they indicate the presence of the abnormal tissue substrate required for the abnormal electrical circuits and heart rhythms that actually lead to SCD. Information about the heart's structure will be obtained from cardiac magnetic resonance imaging and used in combination with a number of other clinical risk factors to see if certain characteristics can better predict patients at risk for SCD. Read Less
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
01/10/2025
Locations: Christiana Care Health Services, Newark, Delaware
Christiana Care Health Services, Newark, Delaware
Conditions: Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy
Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation
Recruiting
This study will evaluate the safety of infusion of the investigational cord blood units by carefully documenting all infusion-related problems.
This study will evaluate the safety of infusion of the investigational cord blood units by carefully documenting all infusion-related problems. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
04/17/2024
Locations: Alfred I. DuPont Hospital for Children, Wilmington, Delaware
Alfred I. DuPont Hospital for Children, Wilmington, Delaware
Conditions: Infusion Reactions
LOWER: Lomitapide Observational Worldwide Evaluation Registry
Recruiting
This global product exposure registry is a multicentre, long-term, prospective, observational cohort study (exposure registry), designed to evaluate the long term safety and effectiveness of lomitapide.
This global product exposure registry is a multicentre, long-term, prospective, observational cohort study (exposure registry), designed to evaluate the long term safety and effectiveness of lomitapide. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
03/11/2024
Locations: Alfieri Cardiology, Newark, Delaware
Alfieri Cardiology, Newark, Delaware
Conditions: Homozygous Familial Hypercholesterolemia
Simple Bone Cysts in Kids
Recruiting
Simple bone cysts (SBCs) are cysts filled with fluid that occur most frequently in the long bones (arms or legs) of children. There are many ways to treat SBCs but it is unclear if one is better than another. The purpose of this research trial is to compare the effectiveness of two common treatments that are used by surgeons today.
Simple bone cysts (SBCs) are cysts filled with fluid that occur most frequently in the long bones (arms or legs) of children. There are many ways to treat SBCs but it is unclear if one is better than another. The purpose of this research trial is to compare the effectiveness of two common treatments that are used by surgeons today. Read Less
Gender:
ALL
Ages:
Between 2 years and 21 years
Trial Updated:
07/10/2023
Locations: Nemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware
Nemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware
Conditions: Bone Cyst
Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial)
Recruiting
This randomized phase III trial studies how well crizotinib works in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called anaplastic lymphoma kinase (ALK). Mutations, or changes, in ALK can make it very active and important for tumor cell growth and progression. Crizotinib may stop the growth of tumor cells by blocking the ALK protein from working. Crizotinib may be an effective treatment for patients with non-sma... Read More
This randomized phase III trial studies how well crizotinib works in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called anaplastic lymphoma kinase (ALK). Mutations, or changes, in ALK can make it very active and important for tumor cell growth and progression. Crizotinib may stop the growth of tumor cells by blocking the ALK protein from working. Crizotinib may be an effective treatment for patients with non-small cell lung cancer and an ALK fusion mutation. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/29/2024
Locations: Beebe South Coastal Health Campus, Frankford, Delaware +9 locations
Beebe South Coastal Health Campus, Frankford, Delaware
Beebe Medical Center, Lewes, Delaware
Christiana Gynecologic Oncology LLC, Newark, Delaware
Delaware Clinical and Laboratory Physicians PA, Newark, Delaware
Helen F Graham Cancer Center, Newark, Delaware
Medical Oncology Hematology Consultants PA, Newark, Delaware
Christiana Care Health System-Christiana Hospital, Newark, Delaware
Beebe Health Campus, Rehoboth Beach, Delaware
TidalHealth Nanticoke / Allen Cancer Center, Seaford, Delaware
Christiana Care Health System-Wilmington Hospital, Wilmington, Delaware
Conditions: ALK Gene Rearrangement, ALK Gene Translocation, ALK Positive, Stage IB Non-Small Cell Lung Carcinoma AJCC v7, Stage II Non-Small Cell Lung Cancer AJCC v7, Stage IIA Non-Small Cell Lung Carcinoma AJCC v7, Stage IIB Non-Small Cell Lung Carcinoma AJCC v7, Stage IIIA Non-Small Cell Lung Cancer AJCC v7
Study to Determine the Pharmacokinetics and Pharmacodynamic Effects of Phenylephrine on BP Via IV
Recruiting
The primary objective of this study is to evaluate the dose effect of Phenylephrine Hydrochloride Injection on the treatment of clinically relevant decreased blood pressure in the pediatric population, ≥12 to 16 year old patients undergoing general and neuraxial anesthesia.
The secondary objectives are to describe changes in blood pressure and heart rate, time to onset and to maximal response, and the duration of response; to assess the safety of the product in this population; and to character... Read More
The primary objective of this study is to evaluate the dose effect of Phenylephrine Hydrochloride Injection on the treatment of clinically relevant decreased blood pressure in the pediatric population, ≥12 to 16 year old patients undergoing general and neuraxial anesthesia.
The secondary objectives are to describe changes in blood pressure and heart rate, time to onset and to maximal response, and the duration of response; to assess the safety of the product in this population; and to characterize the pharmacokinetics of phenylephrine hydrochloride. Read Less
Gender:
ALL
Ages:
Between 12 years and 16 years
Trial Updated:
07/22/2024
Locations: Alfred I. DuPont Hospital for Children, Wilmington, Delaware
Alfred I. DuPont Hospital for Children, Wilmington, Delaware
Conditions: Hypotension
Prospective Multicenter Evaluation of a New Predictive Model for the Progression of Adolescent Idiopathic Scoliosis
Recruiting
Scoliosis is a three-dimensional deformity affecting the orientation and position of the spine. Locally, the shape of the vertebra is also affected. The most common form is adolescent idiopathic scoliosis (AIS) with a prevalence of 1-3% affecting primarily young adolescent females. AIS can either be treated using a brace and in some cases necessitate surgical correction to prevent progressive deformity. Risk factors for progression include female gender, curve magnitude and location, skeletal ma... Read More
Scoliosis is a three-dimensional deformity affecting the orientation and position of the spine. Locally, the shape of the vertebra is also affected. The most common form is adolescent idiopathic scoliosis (AIS) with a prevalence of 1-3% affecting primarily young adolescent females. AIS can either be treated using a brace and in some cases necessitate surgical correction to prevent progressive deformity. Risk factors for progression include female gender, curve magnitude and location, skeletal maturity and growth velocity. However, these risk factors have been shown to be inconsistent in predicting curve progression. Over the past 6 years, the investigators have developed a predictive model of the final Cobb angle in AIS based on 3D spinal parameters. This analysis was based on a prospective cohort of 195 patients that were enrolled upon their initial visit and followed until maturity. This predictive model has a determination coefficient of 0.702. The proposed new study aims at refining and testing the external validity of this model in a larger cohort. The next step towards using the new model in the clinical setting is to redesign the model and to externally validate the model by measuring the agreement between the new method and the traditional Cobb angle at maturity in a larger multicenter study. The objective of this study is to characterize the risk of scoliosis progression based on local three-dimensional vertebral and pelvic measurements present on initial evaluation. Three-dimensional reconstructions will be derived from stereo-radiographs acquired with a new biplanar low-dose radiographic system installed in all 8 clinical sites (EOS system, EOS-Imaging, Paris). These calibrated radiographs will then be used to reconstruct the vertebrae and intervertebral disks at each level as well as the geometry of the pelvis. A series of local and regional parameters will then be calculated from these 3D reconstructions. Correlation analysis will help determine if intervertebral disk wedging, vertebral wedging, transverse plane rotation or pelvic geometry can be used as early predictors of curve progression in AIS.
Identifying a new 3D measure of scoliosis associated with rapid curve progression could help predict which curves need early treatment to prevent further progression. The ultimate goal of this research project will be to validate this new predictive model and finally transfer this new predictive tool in the hands of clinicians treating AIS. Read Less
Gender:
ALL
Ages:
Between 10 years and 15 years
Trial Updated:
04/16/2024
Locations: Alfred I. duPont Hospital for Children, Wilmington, Delaware
Alfred I. duPont Hospital for Children, Wilmington, Delaware
Conditions: Scoliosis
Collection and Storage of Tissue and Blood Samples From Patients With Cancer
Recruiting
This study collects and stores tissue and blood samples from patients with cancer. Collecting and storing samples of tissue and blood from patients with cancer to study in the laboratory may help scientists create new and better models to learn about cancer and to test new cancer drugs.
This study collects and stores tissue and blood samples from patients with cancer. Collecting and storing samples of tissue and blood from patients with cancer to study in the laboratory may help scientists create new and better models to learn about cancer and to test new cancer drugs. Read Less
Gender:
ALL
Ages:
2 months and above
Trial Updated:
02/27/2025
Locations: Delaware Clinical and Laboratory Physicians PA, Newark, Delaware +4 locations
Delaware Clinical and Laboratory Physicians PA, Newark, Delaware
Helen F Graham Cancer Center, Newark, Delaware
Medical Oncology Hematology Consultants PA, Newark, Delaware
Christiana Care Health System-Christiana Hospital, Newark, Delaware
Christiana Care Health System-Wilmington Hospital, Wilmington, Delaware
Conditions: Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, Recurrent Malignant Solid Neoplasm, Hematopoietic and Lymphatic System Neoplasm
Improving Safety and Quality of Tracheal Intubation Practice in Pediatric ICUs
Recruiting
Advanced airway interventions are common high risk, high stakes events for children in intensive care units (ICU) and emergency departments (ED), with risk for life and health threatening consequences.
Advanced airway interventions are common high risk, high stakes events for children in intensive care units (ICU) and emergency departments (ED), with risk for life and health threatening consequences. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
01/21/2025
Locations: Nemours Children's Health, Delaware, Wilmington, Delaware
Nemours Children's Health, Delaware, Wilmington, Delaware
Conditions: Failed or Difficult Intubation, Sequela, Intubation; Difficult, Intubation Complication
Paid Clinical Trials in Delaware
With paid clinical trials in Delaware, you get paid for your time. When you participate in these research studies, you help medicine move forward and boost the quality of life. Trials in Phase 1 pay the most, about $2,000 or more. The bigger the risks, and the longer the study, the higher the rewards.
Phase 4 DE paid clinical trials pay the least, about $400 on average. Volunteers can also receive other forms of compensation, such as covered expenses, travel, and accommodation.
Clinical Trials For Health Volunteers in Delaware
Health volunteers matter. They are the reason we have innovative therapies and life-saving treatments. People who choose to participate become a driving force behind medical breakthroughs.
Research teams in Delaware provide access to some of the best medical treatments. Once you get accepted in a trial, you will be contributing to an extensive database that can align with your interests and goals.
Browse the list below to find clinical trials near you.
Non-Invasive Respiratory Monitor
Recruiting
This study will clinically evaluate a newly developed respiratory monitor - pneuRIP. The pneuRIP uses Respiratory Inductance Plethysmography (RIP) bands to measure key breathing indices non-invasively. This study compares the pneuRIP to an existing Respitrace system (Carefusion, Yorba Linda CA). 10 normal children and 10 children with breathing difficulties will be monitored with both systems.
This study will clinically evaluate a newly developed respiratory monitor - pneuRIP. The pneuRIP uses Respiratory Inductance Plethysmography (RIP) bands to measure key breathing indices non-invasively. This study compares the pneuRIP to an existing Respitrace system (Carefusion, Yorba Linda CA). 10 normal children and 10 children with breathing difficulties will be monitored with both systems. Read Less
Gender:
ALL
Ages:
Between 11 years and 17 years
Trial Updated:
11/18/2024
Locations: Nemours/A.I. duPont Hospital for Children, Wilmington, Delaware
Nemours/A.I. duPont Hospital for Children, Wilmington, Delaware
Conditions: Neuromuscular Diseases, Healthy Volunteers
Medical Discoveries and Innovation in Delaware
Delaware, though small in size, has made significant contributions to healthcare. It has a rich history of clinical research. Here are some of the most notable achievements in the area:
- Delaware Biotechnology Institute (DBI): This research institution, affiliated with the University of Delaware, is the center for research in biotechnology and genomics. Their work has advanced our understanding of genetics and its role in various medical conditions. Their clinical research has helped improve personalized medicine.
- Monitoring Cancer Trends: For years, the Delaware Cancer Registry (DCR) has been monitoring cancer cases, treatments, and deaths. That’s because every case counts. And the data collected can help boost survival rate and quality of life.
- Pediatric Health Data: Cardiac clinical research at Nemours in Delaware is at the forefront of studies about vascular and heart conditions. Experts have done dozens of registries and heart health trials.
Why Delaware Is A Great Place For Clinical Research
The state of Delaware is a practical choice for clinical research as it provides a broad range of volunteers. This diversity can provide more accurate data. Based on recent reports 60.6% of DE residents are White, 22.3% are Black, 10.1% are Hispanic, 4.1% are Asian, and 2.5% are Multiracial.