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Clinical research in South Carolina is here to learn, discover, and heal. The goal is simple: provide scientific discoveries and advance medical knowledge to achieve exceptional healthcare.
You too can be an active participant in driving advances in the world of medicine. And we are happy to assist you on your journey. We provide access to leading trials in your local area.
Clinical Trials For Disease Areas in South Carolina
South Carolina clinical research trials are designed to accommodate a wide range of health problems. Including obesity, hip pain, degenerative disc disease, migraines, multiple sclerosis, and more. With quality data, patients can get better treatment and symptom control.
One groundbreaking clinical trial at MUSC Hollings Cancer Center made headlines in 2021. The results offered new hope for certain leukemia and myelodysplastic syndrome (MDS) patients. Using a medication named AG-120, also known as Tibsovo, the trial provided exceptional results. Patients with limited treatment options increased their chances of a better life and potential remission.
If you want to take part in a clinical trial near you, check the list below. We compiled options that target different diseases, medications, and therapies.
Mucopolysaccharidosis I (MPS I) Registry
Recruiting
The Mucopolysaccharidosis I (MPS I) Registry is an ongoing, observational database that tracks the outcomes of patients with MPS I. The data collected by the MPS I Registry will provide information to better characterize the natural history and progression of MPS I as well as the clinical responses of patients receiving enzyme replacement therapy, such as Aldurazyme (Recombinant Human Alpha-L-Iduronidase), or other treatment modalities.
The objectives of the Registry are:
* To evaluate the lon... Read More
The Mucopolysaccharidosis I (MPS I) Registry is an ongoing, observational database that tracks the outcomes of patients with MPS I. The data collected by the MPS I Registry will provide information to better characterize the natural history and progression of MPS I as well as the clinical responses of patients receiving enzyme replacement therapy, such as Aldurazyme (Recombinant Human Alpha-L-Iduronidase), or other treatment modalities.
The objectives of the Registry are:
* To evaluate the long-term effectiveness and safety of Aldurazyme® (laronidase)
* To characterize and describe the MPS I population as a whole, including the variability, progression, and natural history of MPS I
* To help the MPS I medical community with the development of recommendations for monitoring patients and reports on patient outcomes to optimize patient care Read Less
Gender:
ALL
Ages:
All
Trial Updated:
11/19/2024
Locations: Greenwood Genetcs- Site Number : 840055, Greenville, South Carolina
Greenwood Genetcs- Site Number : 840055, Greenville, South Carolina
Conditions: Mucopolysaccharidosis I (MPS I)
Specimen Collection from Pregnant Women At Increased Risk for Fetal Aneuploidy
Recruiting
The specimen collection is designed for the purpose of the development of a noninvasive prenatal test for T21.
The specimen collection is designed for the purpose of the development of a noninvasive prenatal test for T21. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/11/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Medical University of South Carolina, Charleston, South Carolina
Conditions: Down Syndrome, Fetal Aneuploidy
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
Recruiting
Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and b... Read More
Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and biomarkers for progression and prognosis, identifying clinically-relevant phenotypic characteristics, and establishing clearly defined endpoints for interventional studies. Periodic cuts of the database are now available to any interested researcher to use in their research - visit www.enroll-hd.org/for-researchers/access-data/ to learn more. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: University of South Carolina, Columbia, South Carolina
University of South Carolina, Columbia, South Carolina
Conditions: Huntington's Disease
Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation
Recruiting
This study will evaluate the safety of infusion of the investigational cord blood units by carefully documenting all infusion-related problems.
This study will evaluate the safety of infusion of the investigational cord blood units by carefully documenting all infusion-related problems. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
04/17/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Medical University of South Carolina, Charleston, South Carolina
Conditions: Infusion Reactions
Prospective Research Assessment in Multiple Myeloma: An Observational Evaluation (PREAMBLE)
Recruiting
The purpose of this study is to assess the clinical effectiveness of all approved multiple myeloma (MM) therapies in the newly-diagnosed (NDMM) and the relapsed/refractory MM (RRMM) settings in real-world clinical practice.
The purpose of this study is to assess the clinical effectiveness of all approved multiple myeloma (MM) therapies in the newly-diagnosed (NDMM) and the relapsed/refractory MM (RRMM) settings in real-world clinical practice. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/28/2025
Locations: Local Institute, Charleston, South Carolina +1 locations
Local Institute, Charleston, South Carolina
Local Institution - 0016, Charleston, South Carolina
Conditions: Multiple Myeloma
Fracture Recovery for Returning to Duty (Teriparatide STRONG)
Recruiting
FORTEO (teriparatide [rDNA origin]; Eli-Lilly, Indiana, USA) is an injectable synthetic recombinant human parathyroid hormone analog that is commonly used to treat people with osteoporosis. In the current investigation this drug will be tested to evaluate its efficacy to accelerate bone healing and decrease the convalescence time of US Army Basic Trainees who have sustained a diaphyseal tibial stress fracture (DTSF). Investigators from the University of South Carolina will collaborate with milit... Read More
FORTEO (teriparatide [rDNA origin]; Eli-Lilly, Indiana, USA) is an injectable synthetic recombinant human parathyroid hormone analog that is commonly used to treat people with osteoporosis. In the current investigation this drug will be tested to evaluate its efficacy to accelerate bone healing and decrease the convalescence time of US Army Basic Trainees who have sustained a diaphyseal tibial stress fracture (DTSF). Investigators from the University of South Carolina will collaborate with military personnel to perform a prospective, randomized, double-blind, placebo-controlled study at Fort Jackson, SC. Read Less
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
09/01/2020
Locations: Fort Jackson, SC, Columbia, South Carolina
Fort Jackson, SC, Columbia, South Carolina
Conditions: Stress Fracture, Fracture Healing, Military Training
COVID-19 Administration of Single-Dose Subcutaneous Anti- Spike(s) SARS-CoV-2 Monoclonal Antibodies Casirivimab and Imdevimab in High-Risk Pediatric Participants Under 12 Years of Age
Recruiting
The primary objective of the study is to characterize the concentrations of casirivimab+imdevimab in serum over time after a single subcutaneous (SC) administration
The secondary objectives of the study are:
To assess the safety and tolerability of SC or single administration of casirivimab+imdevimab
To assess the occurrence of grade ≥3 injection site reactions and grade ≥3 hypersensitivity reactions, in participants treated with SC doses of casirivimab+imdevimab
To assess the immunogenicity o... Read More
The primary objective of the study is to characterize the concentrations of casirivimab+imdevimab in serum over time after a single subcutaneous (SC) administration
The secondary objectives of the study are:
To assess the safety and tolerability of SC or single administration of casirivimab+imdevimab
To assess the occurrence of grade ≥3 injection site reactions and grade ≥3 hypersensitivity reactions, in participants treated with SC doses of casirivimab+imdevimab
To assess the immunogenicity of casirivimab+imdevimab Read Less
Gender:
All
Ages:
12 years and below
Trial Updated:
12/06/2021
Locations: Coastal Pediatric Research, Charleston, South Carolina
Coastal Pediatric Research, Charleston, South Carolina
Conditions: COVID-19
Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)
Recruiting
The main objective of the study is to assess efficacy and safety of dupilumab given up to 24 weeks in adults with CPUO.
This is a master protocol which includes 2 parallel-treatment, double-blind, 2- arm Phase 3 staggered studies of similar design (Study A and Study B) in male and female participants aged 18 to 90 years with CPUO. Study B design was to be adapted based on the results of Study A.
For both Study A and B, after an up-to-4-week screening period, participants with severe pruritus (... Read More
The main objective of the study is to assess efficacy and safety of dupilumab given up to 24 weeks in adults with CPUO.
This is a master protocol which includes 2 parallel-treatment, double-blind, 2- arm Phase 3 staggered studies of similar design (Study A and Study B) in male and female participants aged 18 to 90 years with CPUO. Study B design was to be adapted based on the results of Study A.
For both Study A and B, after an up-to-4-week screening period, participants with severe pruritus (worst-itch numerical rating scale \[WI-NRS ≥7) will enter a 4-week run-in period and will be treated with a non-sedative antihistamine and an emollient (moisturizer). Participants with severe pruritus (WI-NRS ≥7) at baseline will be randomized (1:1) to be treated for 24 weeks with either dupilumab or matching placebo in addition to their non-sedative antihistamine and emollient regimen. The treatment period for both study A and B will be followed by a 12-week follow-up period. Read Less
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
08/19/2025
Locations: National Allergy and Asthma - North Charleston - Northside Drive- Site Number : 8400032, North Charleston, South Carolina +1 locations
National Allergy and Asthma - North Charleston - Northside Drive- Site Number : 8400032, North Charleston, South Carolina
Diabetol- Site Number : 8400047, Prešov, South Carolina
Conditions: Pruritus
Ablation-Index Guided Ventricular Tachycardia Ablations
Recruiting
Over the last decade, radiofrequency catheter ablation (RFCA) has become an established treatment for ventricular arrhythmias (VA). Due to the challenging nature of visualizing lesion formation in real time and ensuring an effective transmural lesion, different surrogate measures of lesion quality have been used. The Ablation Index (AI) is a variable incorporating power delivery in its formula and combining it with CF and time in a weighted equation which aims at allowing for a more precise esti... Read More
Over the last decade, radiofrequency catheter ablation (RFCA) has become an established treatment for ventricular arrhythmias (VA). Due to the challenging nature of visualizing lesion formation in real time and ensuring an effective transmural lesion, different surrogate measures of lesion quality have been used. The Ablation Index (AI) is a variable incorporating power delivery in its formula and combining it with CF and time in a weighted equation which aims at allowing for a more precise estimation of lesion depth and quality when ablating VAs. AI guidance has previously been shown to improve outcomes in atrial and ventricular ablation in patients with premature ventricular complexes (PVC). However research on outcomes following AI-guidance for VT ablation specifically in patients with structural disease and prior myocardial infarction remains sparse. We aim at conducting a prospective observational multicenter registry investigating the efficacy and safety of AI-guided VA ablation in patient with ischemic and non-ischemic cardiomyopathy. Read Less
Gender:
All
Ages:
18 years and above
Trial Updated:
06/17/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Medical University of South Carolina, Charleston, South Carolina
Conditions: Ventricular Tachycardia, Ventricular Arrythmia, Cardiomyopathies
A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
Recruiting
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy.
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy. Read Less
Gender:
All
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: GSK Investigational Site, Charleston, South Carolina +1 locations
GSK Investigational Site, Charleston, South Carolina
GSK Investigational Site, Greenville, South Carolina
Conditions: Neoplasms
Paid Clinical Trials in South Carolina
Paid clinical trials come with many advantages. First, you can get paid for taking the time to participate. Secondly, you provide valuable data that can take medical research to new heights.
But, how much you get from SC paid clinical trials will vary. It depends on several factors, such as how often you need to visit the doctor, time spent on study-related exams, your condition, how long the study lasts, its phase, and risks, and so on.
Clinical Trials For Health Volunteers in South Carolina
For clinical trials to succeed, research teams in South Carolina need health volunteers who are willing to participate. Volunteers play a fundamental role in advancing the medical field and optimizing patient outcomes. They make new medicine possible.
We can help you shape the future of healthcare. Check the list below to apply to a clinical trial that suits your needs.
Deliver-EE: Evaluating Effects of Meal Delivery
Recruiting
This study will randomly assign 2,300 older adults on waiting lists at fourteen Meals on Wheels programs in Florida, Illinois, Maryland, Tennessee, Texas, North Carolina, South Carolina, and California into two groups who will receive: (a) daily delivery of meals, five days a week or (b) a shipment of 10 frozen meals, every two weeks. Researchers will examine participants' Medicare claims to understand if differences in healthcare utilization occur between the two groups within six months after... Read More
This study will randomly assign 2,300 older adults on waiting lists at fourteen Meals on Wheels programs in Florida, Illinois, Maryland, Tennessee, Texas, North Carolina, South Carolina, and California into two groups who will receive: (a) daily delivery of meals, five days a week or (b) a shipment of 10 frozen meals, every two weeks. Researchers will examine participants' Medicare claims to understand if differences in healthcare utilization occur between the two groups within six months after they start receiving meals. Researchers will also ask participants questions prior to receiving meals, and again at three months, to understand how meals impact their ability to obtain food, their feelings of loneliness, and their overall quality of life. The primary study outcome will be the ratio of days spent in institutional settings (i.e., hospital, nursing home) in the six months after participants begin receiving meals. The secondary outcomes include the ratio of days spent in institutional settings in the three months after participants begin receiving meals, food insecurity, subjective isolation/loneliness, and health-related quality of life. The team will also examine differences in dietary intake between the two groups as an exploratory outcome. Read Less
Gender:
ALL
Ages:
66 years and above
Trial Updated:
04/21/2025
Locations: Meals On Wheels - Anderson, Anderson, South Carolina +1 locations
Meals On Wheels - Anderson, Anderson, South Carolina
Senior Resources Inc, Columbia, South Carolina
Conditions: Healthy
Spectral Characteristics of Memory Transformation
Recruiting
Sometimes, it is necessary to re-learn a previously learned movement behavior, for example, a bad posture during the golf drive or while playing the piano. Unlearning or relearning an intensively trained behavior is particularly important if the behavior is hampering recovery, for example, in chronic pain or after a stroke. With this pilot study, the brain mechanisms that control the change of pre-existing stable memories of a motor skill will be tested with electroencephalography (EEG). Non-inv... Read More
Sometimes, it is necessary to re-learn a previously learned movement behavior, for example, a bad posture during the golf drive or while playing the piano. Unlearning or relearning an intensively trained behavior is particularly important if the behavior is hampering recovery, for example, in chronic pain or after a stroke. With this pilot study, the brain mechanisms that control the change of pre-existing stable memories of a motor skill will be tested with electroencephalography (EEG). Non-invasive brain stimulation will be used to modulate these brain mechanisms and test if it is possible to change the pre-existing motor memory and the learning of a new motor skill. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Medical University of South Carolina, Charleston, South Carolina
Conditions: Healthy
RECOVERS - Realigning Emotion and COgnition Via PrEcision Regulation NetworkS
Recruiting
In this research study, the investigators are examining how brain activity (electrical and blood flow) changes during tests of emotional processing, attention and memory in the magnetic resonance imaging (MRI) scanner and outside the MRI using functional near-infrared spectroscopy (fNIRS). Investigators are also using non-invasive brain stimulation to probe different parts of the brain and measuring brain activity (electrical and blood flow).
Study 1
This study includes healthy participants an... Read More
In this research study, the investigators are examining how brain activity (electrical and blood flow) changes during tests of emotional processing, attention and memory in the magnetic resonance imaging (MRI) scanner and outside the MRI using functional near-infrared spectroscopy (fNIRS). Investigators are also using non-invasive brain stimulation to probe different parts of the brain and measuring brain activity (electrical and blood flow).
Study 1
This study includes healthy participants and researchers hope this will help us develop improved brain-based treatments for emotional difficulties like depression.
Study 2
This study includes participants with depression and researchers hope this will help us develop improved brain-based treatments for emotional difficulties like depression. Read Less
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/11/2024
Locations: Medical Univeristy of South Carolina, Charleston, South Carolina
Medical Univeristy of South Carolina, Charleston, South Carolina
Conditions: Healthy, Depression - Major Depressive Disorder
tFUS Induced Transient Scotoma for Individual Dosing
Recruiting
The purposes of this research study is to:
1. Develop a technique of transcranial Focused Ultrasound Stimulation (tFUS) where meaningful effects on the brain can be easily measured.
2. Use this technique to measure threshold for effective tFUS in individuals.
3. Determine whether disruption of conscious visual detection, versus non-conscious visually-guided behavior have different thresholds for disruption with tFUS.
The purposes of this research study is to:
1. Develop a technique of transcranial Focused Ultrasound Stimulation (tFUS) where meaningful effects on the brain can be easily measured.
2. Use this technique to measure threshold for effective tFUS in individuals.
3. Determine whether disruption of conscious visual detection, versus non-conscious visually-guided behavior have different thresholds for disruption with tFUS. Read Less
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/31/2025
Locations: Medical University of South Carolina Brain Stimulation Division, Charleston, South Carolina
Medical University of South Carolina Brain Stimulation Division, Charleston, South Carolina
Conditions: Healthy
The Effects of High-Intensity Functional Training in Tactical Populations
Recruiting
The purpose of this study is to investigate the effects of high-intensity functional training (HIFT) as compared to traditional resistance training (RT) and concurrent training consisting of RT and high-intensity interval training (HIIT) on physical performance metrics, body composition, and mental and physical readiness of tactical personnel.
The purpose of this study is to investigate the effects of high-intensity functional training (HIFT) as compared to traditional resistance training (RT) and concurrent training consisting of RT and high-intensity interval training (HIIT) on physical performance metrics, body composition, and mental and physical readiness of tactical personnel. Read Less
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
11/29/2024
Locations: University of South Carolina Sport Science Lab, Columbia, South Carolina
University of South Carolina Sport Science Lab, Columbia, South Carolina
Conditions: Healthy
Effects of a Mushroom Blend on Gastrointestinal Symptoms and the Microbiome
Recruiting
This study will investigate the efficacy of a mushroom blend to improve gastrointestinal symptoms and mood. It will also be determining if the mushroom blend has an effect on the gut microbiome and metabolomics.
This study will investigate the efficacy of a mushroom blend to improve gastrointestinal symptoms and mood. It will also be determining if the mushroom blend has an effect on the gut microbiome and metabolomics. Read Less
Gender:
ALL
Ages:
Between 30 years and 60 years
Trial Updated:
06/16/2025
Locations: University of South Carolina Sport Science Lab, Columbia, South Carolina
University of South Carolina Sport Science Lab, Columbia, South Carolina
Conditions: Healthy
Medical Discoveries and Innovation in South Carolina
With more than 1,000 active clinical trials in different research areas, there is no shortage of exciting innovations and discoveries happening in South Carolina. Here are some of the advancements in the state:
- Improved home care: The South Carolina Research Foundation was granted an award to try out a care coordination model for people in South Carolina. The model was focused on patients who require nursing home-level care.
- The SmartState Program: This program supports many clinical trials and brings together the brightest minds in the area. The state uses the program to support South Carolina research institutions across different fields, including healthcare and biotechnology.
- Cancer research: MUSC Hollings Cancer Center has been studying cancer treatment and therapies for years. It has been at the forefront of advancements in oncology.
Why South Carolina Is A Great Place For Clinical Research
Clinical trials in South Carolina require a wide range of patients. Based on data, 63.4% of the state’s residents are White, 26.1% are Black, 6.4% are Hispanic, 1.9% are Multiracial, 1.9% are Asian, and 0.4% are American Indian.