Paid Obesity Clinical Trial

Candace Kastanis

Written by Candace Kastanis

Chemistry B.S. | UC Davis | Clinical Lab Technician

Updated & Fact Checked 7/25/26

What are paid obesity clinical trials?

Paid obesity clinical trials are studies where various obesity-related treatment interventions are measured scientifically for their safety and effectiveness. The participants in these trials are paid a stipend for their medical expenses, travel expenditures, and compensation in exchange for volunteering for the study. Clinical trial sponsors seek to find paid volunteers that best meet the study objectives. The aim is to conduct a safe clinical trial experience and to validate any clinical trial findings related to the targeted treatment intervention.

How do I find paid obesity clinical trials for healthy volunteers near me?

Finding paid obesity clinical trials near you begins with contacting your physician or medical provider. They may be able to recommend a study based on your health profile. We also recommend checking on agencies specializing in listing clinical trial information on clinical trials near you.

Diabetes and Heart Disease Risk in Blacks
Recruiting
It is unknown if obesity contributes to the development of heart disease in African American men and women. This study was created to determine whether there is a relationship between sex and body size and the incidence of heart disease in African American men and women. Researchers will attempt to associate obesity with the presence of heart disease risk factors. Risk factors that will be studied include; total body fat, body fat distribution, fat content of the blood (triglyceride concentrati... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
08/13/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Diabetes, Obesity, Hypertension, Cardiovascular Diseases
Physical and Behavioral Traits of Overweight and Obese Adults
Recruiting
This study will describe the phenotype (physical and behavioral traits) of overweight and obese people. It will characterize the hormones, metabolism, food preferences, fitness and physical activity levels, sleep patterns and thought processes in people with and without weight problems. Genetic material will be collected for studies of the internal codes that influence body weight. People over 18 years of age from all weight categories (lean, overweight, obese) who are reasonably healthy may be... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/22/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Obesity, Healthy Volunteers
Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment
Recruiting
This study will determine whether electrical stimulation of an area of the brain called the dorsolateral prefrontal cortex, which is important in determining the feeling of fullness after eating, affects how much food a person eats and weight loss over 4 weeks. It will also compare weight changes in people who attend weight loss counseling sessions and those who do not over this period of time. Obese, non-diabetic people between 18 and 60 years of age who are in good health and who live in the... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
08/09/2025
Locations: NIDDK, Phoenix, Phoenix, Arizona
Conditions: Electric Stimulation Therapy, Obesity, Weight Loss, Eating
New Heart Imaging Techniques to Evaluate Possible Heart Disease
Recruiting
Background: - Imaging tests, such as magnetic resonance imaging (MRI), can provide information about heart and blood vessels. The tests let doctors can see the amount of blood vessel narrowing and vessel wall thickness. This information may help diagnose and treat heart disease and other conditions that lead to heart attacks. Better MRI methods are needed to improve heart disease diagnosis, especially by avoiding the use of radiation. Researchers are testing new techniques to improve the qualit... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
06/27/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy, Obesity, Diabetes, Healthy Volunteers, Atherosclerosis
Effect of Metformin on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess
Recruiting
This study will test whether metformin administration can ameliorate androgen (male hormone) overproduction in overweight pubertal girls with androgen excess. The investigators hypothesize that improvement in insulin sensitivity by 12 weeks of metformin administration will improve androgen levels after adrenal stimulation testing with adrenocorticotropic hormone (ACTH) or ovarian stimulation testing with recombinant human chorionic gonadotropin (rhCG).
Gender:
FEMALE
Ages:
Between 7 years and 18 years
Trial Updated:
10/25/2023
Locations: University of Virginia Center for Research in Reproduction, Charlottesville, Virginia
Conditions: Obesity, Hyperandrogenemia, Polycystic Ovary Syndrome
Effect of Spironolactone on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess
Recruiting
Whether 12 weeks of spironolactone can reduce androgen production from ovaries and adrenal glands of girls with obesity and androgen excess
Gender:
FEMALE
Ages:
Between 7 years and 18 years
Trial Updated:
10/25/2023
Locations: University of Virginia Center for Research in Reproduction, Charlottesville, Virginia
Conditions: Obesity, Hyperandrogenemia, Polycystic Ovary Syndrome
Energy Expenditure Responses to Different Temperatures
Recruiting
Background: - The way that the body burns calories is known as energy expenditure. Some studies show that when we are cold, we burn more calories to keep our bodies warm. Brown fat is a special kind of fat that can use energy to keep the body warm. Small animals and infants have been known to have brown fat for many years. Recently, it has been suggested that adult humans also have brown fat. If brown fat becomes active (burns calories) in adult humans when exposed to cold, then these people wo... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/13/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Obesity, Normal Physiology
Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention
Recruiting
Background: - Past studies suggest that the best way to improve heart health in the Black community is through community-based programs. Researchers will partner with DC community leaders. They will collect information about the health and health needs of people in mostly Black churches in DC. They will study things that affect heart health, like diabetes, blood pressure, cholesterol, and weight. They will also study how technology can keep track of activities and health. The information will s... Read More
Gender:
ALL
Ages:
Between 19 years and 85 years
Trial Updated:
08/13/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Cardiovascular Disease, Obesity
Study to Investigate Genetic Causes of Severe Early Childhood Onset Obesity.
Recruiting
This study aims to investigate genetic causes of early childhood obesity. The investigators will enroll children and adults with severe early onset obesity (BMI \> 99th percentile) diagnosed prior to 6 years of age. The investigators will ask questions about the health and eating behavior of the participants, and perform a brief physical examination. The investigators will collect saliva or blood to perform genetic testing from the participants and invite family members to enroll in the study.
Gender:
ALL
Ages:
80 years and below
Trial Updated:
09/04/2024
Locations: Boston Children's Hospital, Boston, Massachusetts +1 locations
Conditions: Obesity
Identification of Phenotypic Factors That Predict Success for Weight Loss and Long-term Weight Maintenance
Recruiting
The Investigational Weight Management Clinic now entitled the Weight Management Program at the University of Michigan was created to identify strategies that will result in cost-effective, long term weight management for overweight and obese individuals. The driving hypothesis of the clinic is that the 'one size fits all' philosophy is untenable with a complex disease such as obesity. The clinic will serve as a portal for patients to choose standard clinical care or to explore alternatives from... Read More
Gender:
ALL
Ages:
Between 15 years and 75 years
Trial Updated:
09/09/2024
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Obesity

Who conducts paid obesity clinical trials for healthy volunteers?

Paid obesity clinical trials routinely gain sponsorship by major pharmaceutical companies looking to bring a new drug candidate to market. The clinical trial process is overseen by a principal lead investigator and a clinical trial coordinator who designs the trial type and collects information from the volunteers.


Quick Facts: Paid Obesity Clinical Trials

  • Actively recruiting US studies (July 2026): 631 (ClinicalTrials.gov) — one of the most active research areas in medicine right now
  • Typical eligibility: most medication trials require a BMI of 30 or higher, or 27+ with a weight-related condition such as high blood pressure or sleep apnea
  • Typical compensation: $50–$100 per completed visit; residential metabolic studies pay more
  • Cost to participate: $0 — study medication and visits are covered by the sponsor
  • Related: looking for lifestyle and diet studies too? See paid weight loss clinical trials

Obesity trials beyond weight loss drugs

Obesity research covers more than the medications in the headlines. Studies actively recruiting in 2026 include trials pairing obesity treatment with related conditions — sleep apnea, fatty liver disease, knee osteoarthritis, and heart failure — along with device studies, post-bariatric-surgery follow-ups, and metabolic ward research where your diet is fully controlled during a paid residential stay. If your BMI qualifies, you likely have more study options than any other volunteer group right now.

What are the advantages of participating in paid obesity clinical trial?

The primary advantage of participating in a paid obesity clinical trial is an opportunity to receive a new treatment with no out-of-pocket costs that could help with your obesity-related medical issues. Often, patients report a life-long struggle with obesity placing them at a higher risk for more complications. Participants find volunteering in paid obesity clinical trials motivating and beneficial in their efforts to achieve better health outcomes.


What are the disadvantages of participating in a paid obesity clinical trial?

Unfortunately, your participation in a paid obesity clinical trial does not necessarily equate to a successful outcome. The inability to lose weight may contribute to greater feelings of exasperation and discouragement. There also may be some unplanned difficulties associated with any drug side effects or emotional factors that may accompany the treatment.


How does a paid obesity clinical trial work?

Paid obesity clinical trials are aimed at finding long-term solutions to reduce the risk factors often associated with being overweight. In many cases, the test therapeutic is directed as those who have exhausted the traditional routes towards achieving safe weight loss. Subsequently, paid volunteers are sought to determine how well a new therapeutic intervention works in obese patient populations.

Common requirements include:

  • Keeping medical appointments.
  • Participating in behavioral modification classes or group therapy.
  • Maintaining a diary or journal.
  • Maintaining availability for several types of testing and procedures.

There are four main types of clinical trials. The stage you will be participating in depends upon your area and eligibility profile.

Phase I Paid Clinical Trials

Phase I clinical trials are dedicated to finding the best way to administer to the test therapeutic and the optimal dose for best outcome. The main focus of phase 1 is to determine if the product is safe for use in humans and also how effective the drug is over a specific length of time.

Phase II Paid Clinical Trials

Phase II clinical trials share the same objectives as phase 1, but with a deeper focus on the safety profile. Clinical investigators are looking for any areas of concern associated with use and well the drug is tolerated in patients.

Phase III Paid Clinical Trials

Phase III of the trial phase is focused upon expanding the recruitment pool to diverse patient populations and conditions. Clinical investigators at this point of the clinical trial are testing broader aspects of the chosen test therapeutic to quantify its overall value and effectiveness.

Phase IV Paid Clinical Trials

Phase IV clinical trials are the last stage before gaining FDA approval. This stage is basically demonstrating predictability of the test therapeutic and evaluating its use in various patient sub-populations. The aim of expanding the test values at this stage is to validate the clinical findings to the FDA for approval.


What do researchers learn from conducting paid obesity clinical trials?

Research indicates that the contributing factors leading to obesity are complex. Furthermore, they understand there is not a one-size fits all successful treatment modality for obesity-specific metabolic conditions. Previous clinical obesity-related studies suggest adjunctive treatment options that include lifestyle modification and drug therapies may work just as well as weight-loss surgery.

Exploring less invasive corrective actions for achieving long-term weight loss is especially important for the medical community because some individuals are not ideal candidates for weight loss surgery. Therefore, learning how various sub-populations respond to specific treatments serves to help more individuals with their obesity-related challenges.


Commonly Asked Questions (FAQs)

  • How much are paid obesity clinical trial participants paid on average?

    Paid obesity clinical trial participants receive reimbursement for travel expenses, specific meal plans, and drug or hospital stays. In addition, volunteers receive a stipend in exchange for their participation. The payment amount varies depending on the type of trial and sponsor, the risk involved, and the anticipated length.

  • How do I find out if I am eligible to participate in a paid obesity clinical trial?

    Clinical trial and eligibility information relating to paid obesity clinical trials may have unique requirements to qualify you for the study. The clinical study coordinator or team lead may determine eligibility based on current health and risk factors. They may also look at co-factors associated with your age, gender, medical history, pre-existing condition, and ability to successfully complete the clinical trial.

  • Will participation in a paid obesity clinical trial prevent me from leaving prior to completion?

    Withdrawing from a obesity clinical trial is permitted for any reason. Most clinical care coordinators inform patients at the beginning of the clinical trial about what to expect during your participation.

    Common Reasons Cited by Participants for Discontinuing a Paid Obesity Clinical Trial

    • Side effects from the treatment intervention
    • Discouragement
    • Unplanned move or lifestyle change
    • Financial reasons
    • Job conflict

  • What type of information is normally collected in paid obesity clinical trials?

    You should expect to provide the clinical trial sponsors with detailed personal health and lifestyle information throughout the entire scope of the paid clinical trial. Patients must undergo various medical tests and procedures as part of the evaluation process. Clinical trial coordinators will use this information to determine if you are a suitable candidate. Stakeholders collect as much patient data as possible to validate the endpoint of the clinical trial findings.

    The final report may include:

    • Your blood test values.
    • Changes in personal health related to weight, eating habits, lifestyle
    • Any adverse effects.
    • Personal experience.
    • Enhanced risk factors
    • Health complications

  • How long do paid obesity clinical trials last?

    Paid obesity clinical trials vary in length based on a myriad of factors such as:

    • Clinical trial design and type
    • Clinical sponsor
    • Type of drug intervention
    • Behavioral and lifestyle considerations

  • If I am interested in participating in a paid obesity clinical trial, what questions should I ask?

    You should feel comfortable asking as many questions as you would like as it relates to your personal health experience. The NIH maintains clear guidance for orchestrating a transparent clinical trial experience with a strong emphasis on patient safety.

    Termed as informed consent, the clinical trial sponsors must disclose the following information:

    1. The comprehensive nature of the treatment, procedure, or drug.
    2. Any inherent risks associated with the intended treatment methods.
    3. Reasonable alternatives to the procedure or treatment intervention.
    4. Assessment and acknowledgment that you, the patient, are in complete understanding of items 1-3.

    Informed consent is required and articulates the agreement between you, your healthcare physician, and clinical trial sponsors. The purpose of informed consent is to provide the patient with the details of every facet of the intended clinical trial study plan. This goal of informed consent is to establish trust and confidence between the eligible participant and the clinical trial sponsor team leads.