Paid Clinical Trials for Healthy Volunteers

Candace Kastanis

Written by Candace Kastanis

Chemistry B.S. | UC Davis | Clinical Lab Technician

Updated & Fact Checked 7/30/26

What is a Paid Clinical Trial? 

how to find clinical trials

Demand for healthy volunteers is constant. The NIH Clinical Center maintains a standing healthy volunteer program, and every Phase 1 unit in the country recruits year-round. Using healthy volunteers for paid clinical trials gives researchers the baseline data that every new treatment is measured against.

Using healthy volunteers for paid clinical trials allows researchers to gain relevant insight and information about a specific health condition or chronic disease. Participation assists in the efforts to improve public health and patient outcomes.

How Do I Find Clinical Trials for Healthy Volunteers Near Me? 

You can easily access clinical trial information by contacting your local research hospital or university or by accessing government-sponsored information. In some cases, your doctor may also be able to recommend a paid clinical trial for healthy volunteers based on your personal health history. 

We have compiled the following list of paid clinical trials for healthy volunteers, and click the Search All button at the bottom to find more:

Study of New Magnetic Resonance Imaging Methods of the Brain
Recruiting
The purpose of this investigation is to develop improved magnetic resonance imaging (MRI) techniques and hardware for studying brain function. MRI is a diagnostic tool that provides information about brain chemistry and physiology. This study will evaluate new MRI methods for monitoring blood flow to regions of the brain in response to simple tasks. The MRI machine used in this study is more powerful than those in most hospitals, permitting a higher visual resolution. Normal healthy volunteers... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
08/22/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy, Magnetic Resonance Imaging, Adult, Brain Mapping, fMRI, Healthy Volunteer
Mapping Auricular Vagus Nerve Circuitry
Recruiting
This study will determine how noninvasive nerve stimulation affects human brain, stomach, and autonomic activity.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/22/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Healthy
Cardiac Magnetic Resonance Imaging (MRI) Normal Reference Control Group Testing
Recruiting
The purpose of this research is to understand how to apply cardiac magnetic resonance imaging (CMR) to women with small artery heart disease by looking at the CMRs of women without heart disease. The investigators will study 40 women with no heart disease to learn more about the usefulness of CMR. Women suffer more than men from this disorder of the small vessels compared to the large vessels. This results in delays in diagnosis, missed opportunities for treatment, and likely contributes to the... Read More
Gender:
FEMALE
Ages:
Between 35 years and 65 years
Trial Updated:
08/30/2023
Locations: Cedars-Sinai Women's Heart Center, Los Angeles, California
Conditions: Healthy
Evaluation and Optimization of Ultrasound and/or MRI Hardware and Software
Recruiting
The purpose of this study is to evaluate and optimize ultrasound and/or MRI hardware and software in both existing ultrasound/MRI units as well as in newly installed commercially available ultrasound/MRI units. The study also serves to familiarize the ultrasound/MRI technician staff with how to operate newly installed software sequences or hardware. The information obtained from this study will be utilized to optimize new software sequences and hardware that have been installed on the UMU ultras... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/27/2024
Locations: SUNY Upstate Medical University, Syracuse, New York
Conditions: Healthy
Filgrastim-Mobilized Stem Cells for Transplantation Using Unrelated Donors
Recruiting
The purpose of the study is to: * Establish and evaluate a system for collection of filgrastim-mobilized peripheral blood stem cells from National Marrow Donor Program donors (NMDP) donors * Assess the safety among NMDP donors of filgrastim administration and PBSC leukapheresis * Assess the safety and efficacy of filgrastim-mobilized PBSC in unrelated donor hematopoietic stem cell transplant recipients * Determine the acceptability of stem cell donation by filgrastim stimulated apheresis in nor... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
04/09/2025
Locations: Gift of Life Bone Marrow Foundation, Boca Raton, Florida +3 locations
Conditions: Healthy
The Healthy Elderly Longevity Cohort
Recruiting
With the completion of the human genome project, investigators can now explore new questions in human biology. Previously human genetics focused on highly penetrant, Mendelian traits; however, now rare and common variants can be discovered that affect "common" diseases that have multi-gene architecture with variable penetrance such as breast cancer, diabetes mellitus, and coronary artery disease. This change took place because investigators now have the tools to illuminate the whole genome at on... Read More
Gender:
ALL
Ages:
80 years and above
Trial Updated:
01/15/2025
Locations: Scripps Translational Science Institute, La Jolla, California
Conditions: Healthy
Imaging Techniques in MRI
Recruiting
Background: - Magnetic resonance imaging (MRI) scans must be performed according to specified sets of parameters that provide optimal images of each organ and each area of the body. These scanning parameters are often specific to the institution or organization at which they are employed, and may also depend on the manufacturer of the MRI scanning equipment. Because MRI scanning equipment is always being updated and upgraded, researchers are interested in developing new and optimized scanning p... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/22/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Cardiac Risk Factors, Healthy, Healthy Volunteers
New Heart Imaging Techniques to Evaluate Possible Heart Disease
Recruiting
Background: - Imaging tests, such as magnetic resonance imaging (MRI), can provide information about heart and blood vessels. The tests let doctors can see the amount of blood vessel narrowing and vessel wall thickness. This information may help diagnose and treat heart disease and other conditions that lead to heart attacks. Better MRI methods are needed to improve heart disease diagnosis, especially by avoiding the use of radiation. Researchers are testing new techniques to improve the qualit... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
06/27/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy, Obesity, Diabetes, Healthy Volunteers, Atherosclerosis
International (Pediatric) Peritoneal Biobank
Recruiting
Within few years the peritoneal membrane of adult peritoneal dialysis (PD) patients undergoes substantial morphological transformation, including progressive fibrosis, vasculopathy and neoangiogenesis. Ultrafiltration capacity steadily declines and ultimately results in PD failure. In children, peritoneal biopsies demonstrating PD associated alterations have not yet been obtained. They, however, should be particularly informative, since secondary tissue and vascular pathology related to ageing o... Read More
Gender:
ALL
Ages:
Between 1 day and 90 years
Trial Updated:
12/03/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama +25 locations
Conditions: Kidney Failure, Chronic, Peritoneal Dialysis Complication, Transplantation, Healthy
Glowing and Expecting Follow Up
Recruiting
This study will help us learn more about how a mother's health during pregnancy may influence her child's growth and development later in life.
Gender:
ALL
Ages:
Between 5 years and 14 years
Trial Updated:
01/29/2025
Locations: Arkansas Children's Nutrition Center, Little Rock, Arkansas
Conditions: Healthy

Who Conducts Paid Clinical Trials for Healthy Volunteers? 

A principal investigator or lead clinical trial coordinator oversees the entire scope of the study. Often, independent research teams represent a pharmaceutical company to ensure a safe clinical trial experience for the paid volunteers. Clinical studies aim to learn more about how a specific treatment modality may work in people with a similar health condition.


What are the Advantages and Disadvantages of Participating in Paid Clinical Trials? 

The main advantage is the ability to access a course of treatment before it is available to the public. In addition, participation in a paid clinical study allows you access to life-changing medical care that otherwise might not be easily accessible. Unfortunately, many health insurance providers do not include newer therapeutics in their approved formularies. So, participating in paid clinical trials may provide an opportunity to try groundbreaking therapies for zero out-of-pocket costs and minimal travel expenses.

Your participation in a paid clinical trial may end in disappointment should the trial therapy not work as intended and often the most significant disadvantage for hopeful volunteers. Other drawbacks could include the time and uncovered travel expenses related to routine trial assessments and doctor visits.

Most paid clinical trial volunteers try to stick it out to complete the entire study despite experiencing undesirable side effects. However, you can discuss these concerns with your primary care physician or study coordinator during the informed consent process of the study enrollment.


How Does a Paid Clinical Trial for Healthy Volunteers Work? 

Both non-paid and paid clinical trials are research studies that involve using healthy volunteers to gather information. The two main types of clinical studies are observational studies and clinical trials. Both types engage in comprehensive clinical assessments to test or measure distinct types of medical interventions.  

The length and requirements of paid clinical study participation are different for each. However, you can choose to leave the clinical trial study at will.  

You may notice when searching for clinical trials near you references four separate phases of clinical trials (Phase I, II, III, and IV). 

The phase-breakdown is the clinical trial classification method researchers use to establish a record of safety before a therapeutic drug intervention gains approval by the FDA for use in the public.

Phase I Paid Clinical Trials

Phase I clinical trials are targeted toward achieving the safest possible dosage recommendations and determining the overall efficacy of the therapeutic method involved. In addition, clinical trial investigators are looking for the best administration methods and assessing the intervention on the most comprehensive level possible. In most cases, phase I paid clinical trials use a small number of healthy volunteers to mitigate any risk factors. 

Phase II Paid Clinical Trials

Phase II clinical trials are close to the same as Phase I trials, but with expanded data collection and safety assessments. Doctors may continue to tweak dosing for optimal efficacy and perform more tests to measure how well the patient responds to treatment.

Phase III Paid Clinical Trials

Phase III clinical trials determine the potential for adverse reactions. During this trial phase, it is common for research investigators to examine the effects on various sub-populations and how a treatment plan benefits a patient compared to other drug candidates or combinations. 

Phase IV Paid Clinical Trials

Phase IV clinical trials are designed to measure the effectiveness over a broader range of diverse patient types. Researchers also aim to discover any essential information that may have gone undiscovered during the first three trial phases. At this point, the intervention is close to being introduced to the public market.


What Has Research Taught Us About Paid Clinical Trials?

The contributions made by participating in paid clinical trials are significant and cover an enormous scope of medical and scientific arenas. The research community maintains that the results of clinical trials are beyond helpful in finding improvements in how we age and overall quality of life. 

Clinical trials provide researchers with critical biomarkers that indicate chronic disease precursors such as inflammation, hormone production, and organ function. As a result, highly respected medical professionals cite the importance of clinical trial recruitment and encourage continued efforts towards participation among diverse populations. 

The overwhelming majority of these trials were made possible because of the “resources spent on clinical development of new therapies, which have been provided by pharmaceutical, biotechnology, and device companies.” As Judith M. Kramer, MD, MS, an associate professor of medicine at Duke University noted, “without the contributions of these organizations, along with those of the health professionals and patients who participate in clinical trials, public health in the US would not be what it is today.” {Source: PolicyMed}


Quick Facts: Paid Clinical Trials for Healthy Volunteers

  • Actively recruiting US healthy-volunteer studies (July 2026): 371 (ClinicalTrials.gov), plus healthy comparison groups in many condition studies
  • Typical compensation: $50–$100 per outpatient visit; residential Phase 1 studies pay $3,000–$15,000 (the highest paid category)
  • What you do: provide the healthy baseline — blood draws, monitoring, first-in-human dosing under medical supervision
  • Cost to participate: $0 — care, meals, and lodging during stays are covered
  • Between studies: Phase 1 units typically require a washout period, often around 30 days, before you can join another drug study

Can I make a habit of healthy volunteer studies?

Some people do treat Phase 1 participation as recurring income, and research units allow it within limits. Expect a washout period between drug studies, usually around 30 days, so residues from one study cannot contaminate the next. Units screen for recent participation, and honesty matters here for your own safety. Observational and survey studies usually have no such gap. If you want steady participation, register with a dedicated Phase 1 unit near you and take studies as your schedule allows — see our trials by state page to find one.

Commonly Asked Questions (FAQs)

  • Do paid clinical trials for healthy volunteers provide compensation?

    Yes. Healthy volunteer studies are among the best paid in research because participants receive no treatment benefit — compensation is the point. Outpatient visits typically pay $50–$100, and residential Phase 1 studies commonly pay $3,000–$15,000 for stays of one to four weeks. The exact amount is stated in the consent form.

  • How do I find out if I am eligible to participate in a paid clinical trial near me? 

    Clinical trial and eligibility information are available by contacting the clinical study coordinator or team lead. They may determine if you are eligible by factors related to age, gender, medical history, pre-existing condition, and proximity to the trial site. 
    It is also important to realize that not every clinical trial candidate who seeks enrollment will be selected for the paid clinical study. Despite meeting the required eligibility criteria, the selection is left up to the sole discretion of the study sponsors and chosen to find the best possible candidates for the study type.

  • Can I leave before completion?

    Withdrawing from a paid clinical trial is permitted for any reason. However, most clinical care coordinators inform patients at the beginning of the depth of care involved and any travel requirements. Understanding the expectations can help you make the best-informed decision for you and your family before enrolling in the study. 

    The number of people needed to conduct the study may vary, and obtaining viable results depends heavily upon completion, but it is not mandatory. Discontinuing the clinical study before completion may affect your compensation. Study coordinators want patients to feel safe and assured their best interest is paramount at the time of enrollment.  

    Common reasons for discontinuing participation in a clinical trial:

    – Undesirable side effects
    – Changes in familial or living situations
    – Unforeseen changes in one’s health
    – Financial or job complications

  • What type of information is collected in these studies? 

    The type of information collected varies from study to study. In most cases, paid clinical study volunteers should expect a vast amount of laboratory testing at each of the four clinical trial phases. Researchers typically predetermine the data points relative to their specified trial design. Clinical trial investigators capture vital patient data using questionnaires, medical records, surveys, lab results, genomic assessments, and comprehensive medical evaluations.

  • How long do paid clinical trials last? 

    There is no set timeline for how long paid clinical trials can last. It varies from study to study. Typically, the clinical trial investigator will disclose as many details as possible before enrollment. The goal is for every paid clinical trial volunteer to be able to complete the study in the allotted period without any complications.

  • What questions should I ask if I am interested in participating in a paid clinical trial?

    Participating in a paid clinical trial means you are entitled to certain pre-enrollment checks and balances; one is informed consent. The NIH maintains clear guidance for safe and ethical clinical trial programs. As such, the hallmark elements of an informed consent disclosure must include:

    1. The comprehensive nature of the treatment, procedure, or drug. The risks and benefits associated.
    2. Reasonable alternatives to the procedure or treatment intervention.
    3. Assessment and acknowledgment that you, the patient, are in complete understanding of items 1-3.

    Informed consent details the communications required between you, your healthcare physician, or your clinical trial providers. The purpose of informed consent is to give the patient complete transparency with every facet of the intended clinical trial study plan. This level of transparency also contributes to establishing trust before moving forward with the participation process.

    What to ask:
    – You may want to ask questions related to the purpose or goal of the clinical study you are interested in.
    – You may ask if family members may accompany you during hospital stays or doctor visits.
    – It would be appropriate to ask questions related to the likelihood of discomfort, pain, or side effects that may be experienced.
    – Ask if a hospital stay might be necessary.
    – Be sure to discuss any travel arrangements and compensation.
    – Some clinical studies are randomized and include the use of a placebo. Therefore, ask what type of trial design and what is involved with the paid clinical study you are interested in. 
    – Inquire as to whether you will be able to access results.
    – Inquire as to the number of people involved in the study.
    – You can ask questions about similar studies or any previous attempts of the same study.
    – Questions related to post-care strategies are advised.