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Clinical research in Hawaii combines years of experience to provide patients with new treatment options, better care, and quality of life. Research trials are done to find an efficient solution to a disease. But, they also help pharmaceutical companies launch new medications.
Every year hundreds of volunteers step forward to participate in research. You too can make a difference.
Clinical Trials For Disease Areas in Hawaii
Clinical trials are the bedrock of medical progress. Hawaii boasts formidable research strengths in several medical domains. With a keen focus on infectious diseases, particularly vector-borne illnesses like dengue fever and Zika virus. Hawaii’s research community has made significant strides in understanding and combating these threats.
The state is also a hub for cancer research and other diseases. Especially heart disease, neurodegenerative disorders, pediatric medicine, and more. Reports show that Hawaii received top scores in 2023 for its healthcare system. It once again ranked among the best states with superior quality care.
If you want to apply for clinical research trials in Hawaii, browse our curated selection of trials. We compiled a list of all the active and future trials in your local area.
Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies
Recruiting
This clinical trial keeps track of and collects follow-up information from patients who are currently enrolled on or have participated in a Children's Oncology Group study. Developing a way to keep track of patients who have participated in Children's Oncology Group studies may allow doctors learn more about the long-term effects of cancer treatment and help them reduce problems related to treatment and improve patient quality of life.
This clinical trial keeps track of and collects follow-up information from patients who are currently enrolled on or have participated in a Children's Oncology Group study. Developing a way to keep track of patients who have participated in Children's Oncology Group studies may allow doctors learn more about the long-term effects of cancer treatment and help them reduce problems related to treatment and improve patient quality of life. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
07/22/2025
Locations: University of Hawaii Cancer Center, Honolulu, Hawaii +1 locations
University of Hawaii Cancer Center, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Conditions: Hematopoietic Cell Transplantation Recipient, Leukemia, Solid Tumor
Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
Recruiting
This research trial studies biomarkers in tumor tissue samples from patients with newly diagnosed neuroblastoma or ganglioneuroblastoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
This research trial studies biomarkers in tumor tissue samples from patients with newly diagnosed neuroblastoma or ganglioneuroblastoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. Read Less
Gender:
ALL
Ages:
30 years and below
Trial Updated:
04/14/2025
Locations: University of Hawaii Cancer Center, Honolulu, Hawaii +2 locations
University of Hawaii Cancer Center, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Tripler Army Medical Center, Honolulu, Hawaii
Conditions: Ganglioneuroblastoma, Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma, Regional Neuroblastoma, Stage 4 Neuroblastoma, Stage 4S Neuroblastoma
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)
Recruiting
This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications.
This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
04/15/2025
Locations: Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Conditions: Hematologic Malignancies, Inherited Disorders of Metabolism, Inherited Abnormalities of Platelets, Histiocytic Disorders, Acute Myelogenous Leukemia (AML or ANLL), Acute Lymphoblastic Leukemia (ALL), Other Acute Leukemia, Chronic Myelogenous Leukemia (CML), Myelodysplastic (MDS) / Myeloproliferative (MPN) Diseases, Other Leukemia, Hodgkin Lymphoma, Non-hodgkin Lymphoma, Multiple Myeloma/ Plasma Cell Disorder (PCD), Inherited Abnormalities of Erythrocyte Differentiation or Function, Disorders of the Immune System, Severe Aplastic Anemia, Autoimmune Diseases
Patient Retrospective Outcomes (PRO)
Recruiting
This study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain.
This study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/11/2025
Locations: Tripler Army Medical Center, Honolulu, Hawaii
Tripler Army Medical Center, Honolulu, Hawaii
Conditions: Chronic Pain
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment
Recruiting
This clinical trial studies the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer treatment. Studying samples of blood in the laboratory from patients receiving dexrazoxane hydrochloride may help doctors learn more about the effects of dexrazoxane hydrochloride on cells. It may also help doctors understand how well patients respond to treatment.
This clinical trial studies the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer treatment. Studying samples of blood in the laboratory from patients receiving dexrazoxane hydrochloride may help doctors learn more about the effects of dexrazoxane hydrochloride on cells. It may also help doctors understand how well patients respond to treatment. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
05/22/2025
Locations: University of Hawaii Cancer Center, Honolulu, Hawaii +1 locations
University of Hawaii Cancer Center, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Conditions: Hodgkin Lymphoma in Remission, Leukemia in Remission, Lymphoblastic Lymphoma, Osteosarcoma, Recurrent Leukemia, Recurrent Lymphoma, Recurrent Malignant Neoplasm
Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer
Recruiting
This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage III-IV head and neck cancer the begins in the thin, flat cells (squamous cell). Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin and docetaxel, wor... Read More
This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage III-IV head and neck cancer the begins in the thin, flat cells (squamous cell). Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Cetuximab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The purpose of this study is to compare the usual treatment (radiation therapy with cisplatin chemotherapy) to using radiation therapy with docetaxel and cetuximab chemotherapy, and using the usual treatment plus an immunotherapy drug, atezolizumab. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: Queen's Medical Center, Honolulu, Hawaii +1 locations
Queen's Medical Center, Honolulu, Hawaii
The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii
Conditions: Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7, Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7, Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7, Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7, Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7, Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7, Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7, Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7, Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma
A Study of Intravesical BCG in Combination With ALT-803 in Patients With Non-Muscle Invasive Bladder Cancer
Recruiting
This is a Phase Ib/IIb, randomized, two-cohort, open-label, multicenter study of intravesical N-803 plus BCG versus BCG alone, in BCG naïve patients with high-grade NMIBC.
This is a Phase Ib/IIb, randomized, two-cohort, open-label, multicenter study of intravesical N-803 plus BCG versus BCG alone, in BCG naïve patients with high-grade NMIBC. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: University of Hawaii Cancer Center, Honolulu, Hawaii
University of Hawaii Cancer Center, Honolulu, Hawaii
Conditions: Non-muscle Invasive Bladder Cancer
Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial)
Recruiting
This randomized phase III trial studies how well crizotinib works in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called anaplastic lymphoma kinase (ALK). Mutations, or changes, in ALK can make it very active and important for tumor cell growth and progression. Crizotinib may stop the growth of tumor cells by blocking the ALK protein from working. Crizotinib may be an effective treatment for patients with non-sma... Read More
This randomized phase III trial studies how well crizotinib works in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called anaplastic lymphoma kinase (ALK). Mutations, or changes, in ALK can make it very active and important for tumor cell growth and progression. Crizotinib may stop the growth of tumor cells by blocking the ALK protein from working. Crizotinib may be an effective treatment for patients with non-small cell lung cancer and an ALK fusion mutation. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/29/2024
Locations: Hawaii Cancer Care - Savio, 'Aiea, Hawaii +21 locations
Hawaii Cancer Care - Savio, 'Aiea, Hawaii
Pali Momi Medical Center, 'Aiea, Hawaii
Queen's Cancer Center - Pearlridge, 'Aiea, Hawaii
Straub Pearlridge Clinic, 'Aiea, Hawaii
The Cancer Center of Hawaii-Pali Momi, 'Aiea, Hawaii
The Queen's Medical Center - West Oahu, 'Ewa Beach, Hawaii
Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu, Hawaii
Island Urology, Honolulu, Hawaii
Queen's Cancer Cenrer - POB I, Honolulu, Hawaii
Queen's Medical Center, Honolulu, Hawaii
Straub Clinic and Hospital, Honolulu, Hawaii
University of Hawaii Cancer Center, Honolulu, Hawaii
Hawaii Cancer Care Inc-Liliha, Honolulu, Hawaii
Hawaii Diagnostic Radiology Services LLC, Honolulu, Hawaii
Kuakini Medical Center, Honolulu, Hawaii
Queen's Cancer Center - Kuakini, Honolulu, Hawaii
The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii
Kaiser Permanente Moanalua Medical Center, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Straub Medical Center - Kahului Clinic, Kahului, Hawaii
Castle Medical Center, Kailua, Hawaii
Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue, Hawaii
Conditions: ALK Gene Rearrangement, ALK Gene Translocation, ALK Positive, Stage IB Non-Small Cell Lung Carcinoma AJCC v7, Stage II Non-Small Cell Lung Cancer AJCC v7, Stage IIA Non-Small Cell Lung Carcinoma AJCC v7, Stage IIB Non-Small Cell Lung Carcinoma AJCC v7, Stage IIIA Non-Small Cell Lung Cancer AJCC v7
A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma
Recruiting
This phase II/III trial studies the side effects of nivolumab and ipilimumab when given together with or without sargramostim and to see how well they work in treating patients with stage III-IV melanoma that cannot be removed by surgery (unresectable) and that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the body's immune system attack the c... Read More
This phase II/III trial studies the side effects of nivolumab and ipilimumab when given together with or without sargramostim and to see how well they work in treating patients with stage III-IV melanoma that cannot be removed by surgery (unresectable) and that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Colony-stimulating factors, such as sargramostim, may increase the production of white blood cells. It is not yet known whether nivolumab and ipilimumab are more effective with or without sargramostim in treating patients with melanoma. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/16/2025
Locations: Hawaii Cancer Care - Westridge, 'Aiea, Hawaii +21 locations
Hawaii Cancer Care - Westridge, 'Aiea, Hawaii
Pali Momi Medical Center, 'Aiea, Hawaii
Queen's Cancer Center - Pearlridge, 'Aiea, Hawaii
Straub Pearlridge Clinic, 'Aiea, Hawaii
The Cancer Center of Hawaii-Pali Momi, 'Aiea, Hawaii
The Queen's Medical Center - West Oahu, 'Ewa Beach, Hawaii
Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu, Hawaii
Island Urology, Honolulu, Hawaii
Queen's Cancer Cenrer - POB I, Honolulu, Hawaii
Queen's Medical Center, Honolulu, Hawaii
Straub Clinic and Hospital, Honolulu, Hawaii
University of Hawaii Cancer Center, Honolulu, Hawaii
Hawaii Cancer Care Inc-Liliha, Honolulu, Hawaii
Hawaii Diagnostic Radiology Services LLC, Honolulu, Hawaii
Kuakini Medical Center, Honolulu, Hawaii
Queen's Cancer Center - Kuakini, Honolulu, Hawaii
The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii
Kaiser Permanente Moanalua Medical Center, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Straub Medical Center - Kahului Clinic, Kahului, Hawaii
Castle Medical Center, Kailua, Hawaii
Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue, Hawaii
Conditions: Stage III Cutaneous Melanoma AJCC v7, Stage IV Cutaneous Melanoma AJCC v6 and v7
Project: Every Child for Younger Patients With Cancer
Recruiting
This study gathers health information for the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.
This study gathers health information for the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care. Read Less
Gender:
ALL
Ages:
25 years and below
Trial Updated:
08/08/2025
Locations: Kapiolani Medical Center for Women and Children, Honolulu, Hawaii +1 locations
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Tripler Army Medical Center, Honolulu, Hawaii
Conditions: Central Nervous System Neoplasm, Childhood Immature Teratoma, Childhood Langerhans Cell Histiocytosis, Childhood Mature Teratoma, Congenital Mesoblastic Nephroma, Lymphoproliferative Disorder, Myeloproliferative Neoplasm, Stromal Neoplasm, Carcinoma In Situ, Malignant Solid Neoplasm, Desmoid Fibromatosis, Ganglioneuroma, Melanocytic Neoplasm, Neuroendocrine Neoplasm, Adrenal Gland Pheochromocytoma, Malignant Neoplasm, Neoplasm of Uncertain Malignant Potential, Childhood Kidney Neoplasm
Paid Clinical Trials in Hawaii
For every big story in medicine, there is a clinical trial to thank. Paid clinical trials are one of the most popular methods for collecting data for experimental treatments, medical devices, or health problems.
With HI paid clinical trials volunteers are paid for their efforts. They can receive monetary compensation or non-monetary benefits. Like medical care, covered expenses for housing, transportation, or food.
Click here for Hawaii clinical trials in Honolulu
Clinical Trials For Health Volunteers in Hawaii
Health volunteers play a key role in advancing medical science. With your help, research teams in Hawaii can rigorously test and refine new treatments. This will ultimately lead to safer and more effective therapies.
Check the list below to find one clinical trial that accommodates your needs.
No trials could be found at this time
Medical Discoveries and Innovation in Hawaii
Hawaii’s healthcare community is at the forefront of medical innovation. With world-class research institutions and a network of pioneering researchers, they’ve improved the lives of the people in Hawaii and the world. Here are some of the most notable achievements in the region.
- Leptospirosis Research: Alan R. Katz and a team of leading epidemiologists made significant strides in the study of leptospirosis in Hawaii. Their research has improved diagnostic methods and led to more effective preventive measures.
- Tropical Medicine Advancements: Dr. Richard Yanagihara’s health disparity research is widely recognized for its success. His work has been instrumental in understanding and mitigating the impact of infectious diseases in Hawaii and beyond.
- Cancer Epidemiology Studies: Clinical trials from the University of Hawaii provided critical insight into the genetic and environmental factors that influence cancer risk. Achievements include reducing the risk of chemotherapy-induced nausea and vomiting (CINV) with olanzapine.
Why Hawaii Is A Great Place For Clinical Research
The state of Hawaii has some of the most diverse populations. This makes it a perfect choice for clinical research. Around 35.5% of its residents are Asian, 21.4% are White, 20.2% are Multiracial, 11.1% are Hispanic, 9.7% are Native Hawaiian, and 1.9% are Black.