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Clinical research provides Rhode Island residents with access to promising therapies and cutting-edge treatments across various medical specialties. We are your gateway to the latest advancements in healthcare.
Our platform is here to connect volunteers with medical studies. We provide access to new trials done by reputable institutions.
Clinical Trials For Disease Areas in Rhode Island
At the heart of Rhode Island clinical research trials, is a patient-centered approach. Researchers make sure that every patient gets access to the best quality care that can improve their health and well-being.
RI experts study many disease areas. Including brain conditions, cancer, heart disease, genetic disorders, molecular biology and immunology.
For example, the first surgery that uses IlluminOss‘s innovative technology took place at Rhode Island Hospital. It was part of a U.S. clinical trial. The implant is the first of its kind. It provides rapid internal support for bones affected by cancer. A patient was successfully treated with this groundbreaking technology for repairing orthopedic fractures.
Want to take part in a trial? Explore the wide range of clinical trials below. They cover different medical conditions and treatments.
Follow-up Visit of High Risk Infants
Recruiting
The NICHD Neonatal Research Network's Follow-Up study is a multi-center cohort in which surviving extremely low birth-weight infants born in participating network centers receive neurodevelopmental, neurosensory and functional assessments at 22-26 months corrected age (Infants born prior to July 1, 2012 were seen at 18-22 months corrected age). Data regarding pregnancy and neonatal outcome are collected prospectively. The goal is to identify potential maternal and neonatal risk factors that may... Read More
The NICHD Neonatal Research Network's Follow-Up study is a multi-center cohort in which surviving extremely low birth-weight infants born in participating network centers receive neurodevelopmental, neurosensory and functional assessments at 22-26 months corrected age (Infants born prior to July 1, 2012 were seen at 18-22 months corrected age). Data regarding pregnancy and neonatal outcome are collected prospectively. The goal is to identify potential maternal and neonatal risk factors that may affect infant neurodevelopment. Read Less
Gender:
ALL
Ages:
Between 18 months and 26 months
Trial Updated:
02/11/2025
Locations: Brown University, Women & Infants Hospital of Rhode Island, Providence, Rhode Island
Brown University, Women & Infants Hospital of Rhode Island, Providence, Rhode Island
Conditions: Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
Consent for Use of Stored Patient Specimens for Future Testing
Recruiting
The purpose of this study is to obtain informed consent to use stored human biological materials (HBM) (e.g., blood and other tissues) for future studies that may include genetic testing.
The purpose of this study is to obtain informed consent to use stored human biological materials (HBM) (e.g., blood and other tissues) for future studies that may include genetic testing. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
09/20/2024
Locations: Miriam Hosp / Brown Univ, Providence, Rhode Island
Miriam Hosp / Brown Univ, Providence, Rhode Island
Conditions: HIV Infections
Generic Database of Very Low Birth Weight Infants
Recruiting
The Generic Database (GDB) is a registry of very low birth weight infants born alive in NICHD Neonatal Research Network (NRN) centers. The GDB collects observational baseline data on both mothers and infants, and the therapies used and outcomes of the infants. The information collected is not specific to a disease or treatment (i.e., it is "generic"). Data are analyzed to find associations and trends between baseline information, treatments, and infant outcome, and to develop future NRN trials.
The Generic Database (GDB) is a registry of very low birth weight infants born alive in NICHD Neonatal Research Network (NRN) centers. The GDB collects observational baseline data on both mothers and infants, and the therapies used and outcomes of the infants. The information collected is not specific to a disease or treatment (i.e., it is "generic"). Data are analyzed to find associations and trends between baseline information, treatments, and infant outcome, and to develop future NRN trials. Read Less
Gender:
ALL
Ages:
14 days and below
Trial Updated:
02/11/2025
Locations: Brown University, Women & Infants Hospital of Rhode Island, Providence, Rhode Island
Brown University, Women & Infants Hospital of Rhode Island, Providence, Rhode Island
Conditions: Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
Mucopolysaccharidosis I (MPS I) Registry
Recruiting
The Mucopolysaccharidosis I (MPS I) Registry is an ongoing, observational database that tracks the outcomes of patients with MPS I. The data collected by the MPS I Registry will provide information to better characterize the natural history and progression of MPS I as well as the clinical responses of patients receiving enzyme replacement therapy, such as Aldurazyme (Recombinant Human Alpha-L-Iduronidase), or other treatment modalities.
The objectives of the Registry are:
* To evaluate the lon... Read More
The Mucopolysaccharidosis I (MPS I) Registry is an ongoing, observational database that tracks the outcomes of patients with MPS I. The data collected by the MPS I Registry will provide information to better characterize the natural history and progression of MPS I as well as the clinical responses of patients receiving enzyme replacement therapy, such as Aldurazyme (Recombinant Human Alpha-L-Iduronidase), or other treatment modalities.
The objectives of the Registry are:
* To evaluate the long-term effectiveness and safety of Aldurazyme® (laronidase)
* To characterize and describe the MPS I population as a whole, including the variability, progression, and natural history of MPS I
* To help the MPS I medical community with the development of recommendations for monitoring patients and reports on patient outcomes to optimize patient care Read Less
Gender:
ALL
Ages:
All
Trial Updated:
11/19/2024
Locations: Rhode Island Hospital Genetics- Site Number : 840053, Providence, Rhode Island
Rhode Island Hospital Genetics- Site Number : 840053, Providence, Rhode Island
Conditions: Mucopolysaccharidosis I (MPS I)
Fabry Disease Registry & Pregnancy Sub-registry
Recruiting
The Fabry Registry is an ongoing, international multi-center, strictly observational program that tracks the routine clinical outcomes for patients with Fabry disease, irrespective of treatment status. No experimental intervention is involved; patients in the Registry undergo clinical assessments and receive care as determined by the patient's treating physician.
The primary objectives of the Registry are:
* To enhance the understanding of the variability, progression, and natural history of F... Read More
The Fabry Registry is an ongoing, international multi-center, strictly observational program that tracks the routine clinical outcomes for patients with Fabry disease, irrespective of treatment status. No experimental intervention is involved; patients in the Registry undergo clinical assessments and receive care as determined by the patient's treating physician.
The primary objectives of the Registry are:
* To enhance the understanding of the variability, progression, and natural history of Fabry disease, including heterozygous females with the disease;
* To assist the Fabry medical community with the development of recommendations for monitoring patients and reports on patient outcomes to help optimize patient care;
* To characterize and describe the Fabry population as a whole;
* To evaluate the long-term safety and effectiveness of Fabrazyme®
Fabry Pregnancy Sub-registry: This Sub-registry is a multicenter, international, longitudinal, observational, and voluntary program designed to track pregnancy outcomes for any pregnant woman enrolled in the Fabry Registry, regardless of whether she is receiving disease-specific therapy (such as enzyme replacement therapy with agalsidase beta) and irrespective of the commercial product with which she may be treated. Data from the Sub-registry are also used to fulfill various global regulatory requirements, to support product development/reimbursement, and for other research and non-research-related purposes. No experimental intervention is given; thus a patient will undergo clinical assessments and receive standard of care treatment as determined by the patient's physician. If a patient consents to this Sub-registry, information about the patient's medical and obstetric history, pregnancy, and birth will be collected, and, if a patient consents to data collection for her infant, data on infant growth through month 36 postpartum will be collected. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
08/07/2025
Locations: Rhode Island Hospital Genetics- Site Number : 840053, Providence, Rhode Island
Rhode Island Hospital Genetics- Site Number : 840053, Providence, Rhode Island
Conditions: Fabry Disease
Pompe Disease Registry Protocol
Recruiting
The Pompe Registry is a global, multicenter, international, longitudinal, observational, and voluntary program for patients with Pompe disease, designed to track the disease's natural history and outcomes in patients, both treated and not. Data from the Registry are also used to fulfill various global regulatory commitments, to support product development/reimbursement, and for other research and non-research related purposes.
The objectives of the Registry are:
* To enhance understanding of t... Read More
The Pompe Registry is a global, multicenter, international, longitudinal, observational, and voluntary program for patients with Pompe disease, designed to track the disease's natural history and outcomes in patients, both treated and not. Data from the Registry are also used to fulfill various global regulatory commitments, to support product development/reimbursement, and for other research and non-research related purposes.
The objectives of the Registry are:
* To enhance understanding of the variability, progression, identification, and natural history of Pompe disease, with the ultimate goal of better guiding and assessing therapeutic intervention.
* To assist the Pompe medical community with the development of recommendations for monitoring patients, and to provide reports on patient outcomes, to optimize patient care.
* To characterize the Pompe disease population.
* To evaluate the long-term effectiveness of alglucosidase alfa. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
08/06/2025
Locations: Rhode Island Hospital Genetics- Site Number : 840053, Providence, Rhode Island
Rhode Island Hospital Genetics- Site Number : 840053, Providence, Rhode Island
Conditions: Glycogen Storage Disease Type II, Pompe Disease
International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry
Recruiting
The ICGG Gaucher Registry is an ongoing, international multi-center, strictly observational program that tracks the routine clinical outcomes for patients with Gaucher disease, irrespective of treatment status. No experimental intervention is involved; patients in the Registry undergo clinical assessments and receive care as determined by the patient's treating physician.
The objectives of the Registry are:
* To enhance understanding of the variability, progression, identification, and natural... Read More
The ICGG Gaucher Registry is an ongoing, international multi-center, strictly observational program that tracks the routine clinical outcomes for patients with Gaucher disease, irrespective of treatment status. No experimental intervention is involved; patients in the Registry undergo clinical assessments and receive care as determined by the patient's treating physician.
The objectives of the Registry are:
* To enhance understanding of the variability, progression, identification, and natural history of Gaucher disease, with the ultimate goal of better guiding and assessing therapeutic intervention.
* To assist the Gaucher medical community with the development of recommendations for monitoring patients, and to provide reports on patient outcomes, to optimize patient care.
* To characterize the Gaucher disease population.
* To evaluate the long-term effectiveness of imiglucerase and of eliglustat.
Gaucher Pregnancy Sub-registry: The primary objective of this Sub-registry is to track pregnancy outcomes, including complications and infant growth, in all women with Gaucher disease during pregnancy, regardless of whether they receive disease-specific therapy. No experimental intervention is given; thus a patient will undergo clinical assessments and receive standard of care treatment as determined by the patient's physician.If a patient consents to this Sub-registry, information about the patient's medical and obstetric history, pregnancy, and birth will be collected, and, if a patient consents to data collection for her infant, data on infant growth through month 36 postpartum will be collected. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
08/12/2025
Locations: Rhode Island Hospital Genetics- Site Number : 840053, Providence, Rhode Island
Rhode Island Hospital Genetics- Site Number : 840053, Providence, Rhode Island
Conditions: Gaucher Disease, Cerebroside Lipidosis Syndrome, Glucocerebrosidase Deficiency Disease, Glucosylceramide Beta-Glucosidase Deficiency Disease
Use of the CA 125 Algorithm for the Early Detection of Ovarian Cancer in Low Risk Women
Recruiting
The goal of this clinical research study is to evaluate a method involving 4 blood tests called CA-125, HE4, HE4 antigen autoantibody complexes, and osteopontin that may be helpful in the early detection of ovarian cancer in women who are at low risk.
The goal of this clinical research study is to evaluate a method involving 4 blood tests called CA-125, HE4, HE4 antigen autoantibody complexes, and osteopontin that may be helpful in the early detection of ovarian cancer in women who are at low risk. Read Less
Gender:
FEMALE
Ages:
Between 50 years and 74 years
Trial Updated:
04/08/2025
Locations: Women's and Infant's Hospital, Providence, Rhode Island
Women's and Infant's Hospital, Providence, Rhode Island
Conditions: Ovarian Cancer
Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies
Recruiting
This clinical trial keeps track of and collects follow-up information from patients who are currently enrolled on or have participated in a Children's Oncology Group study. Developing a way to keep track of patients who have participated in Children's Oncology Group studies may allow doctors learn more about the long-term effects of cancer treatment and help them reduce problems related to treatment and improve patient quality of life.
This clinical trial keeps track of and collects follow-up information from patients who are currently enrolled on or have participated in a Children's Oncology Group study. Developing a way to keep track of patients who have participated in Children's Oncology Group studies may allow doctors learn more about the long-term effects of cancer treatment and help them reduce problems related to treatment and improve patient quality of life. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
07/22/2025
Locations: Rhode Island Hospital, Providence, Rhode Island
Rhode Island Hospital, Providence, Rhode Island
Conditions: Hematopoietic Cell Transplantation Recipient, Leukemia, Solid Tumor
Dominantly Inherited Alzheimer Network (DIAN)
Recruiting
The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.
The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: Butler Hospital, Providence, Rhode Island
Butler Hospital, Providence, Rhode Island
Conditions: Alzheimer's Disease
Paid Clinical Trials in Rhode Island
In paid clinical trials, participants get something in return. This could be money, or it can cover things like consumables, travel costs, or vouchers. Patients can also get other kinds of services, such as reduced medical expenses.
Before RI paid clinical trials start, it’s established who gets the reimbursement. Whether it’s the participants themselves or their chosen representatives. It’s a great way to get some cash and help advance medical knowledge.
Clinical Trials For Health Volunteers in Rhode Island
Together, we can make a difference. Health volunteers are a key component in research trials. Without your help, research teams in Rhode Island can’t improve patient outcomes, and test different treatments, medical devices, and medications.
Your feedback matters. Check the list below if you want to apply to some active or future trials in your local area.
Feasibility and Acceptability of Mindful Self-Compassion Among Transgender and Nonbinary Young Adults
Recruiting
The goal of this single-arm feasibility study is to evaluate the feasibility and acceptability of an 8-week mindful self-compassion intervention and associated data-collection plan among transgender and nonbinary young adults. Participants will be asked to:
* Complete weekly 2.5-hour virtual classes for 8 weeks and a 4-hour virtual retreat
* Practice specific activities in between classes for 20-30 minutes a day
* Answer survey questions before starting the intervention, half-way through the in... Read More
The goal of this single-arm feasibility study is to evaluate the feasibility and acceptability of an 8-week mindful self-compassion intervention and associated data-collection plan among transgender and nonbinary young adults. Participants will be asked to:
* Complete weekly 2.5-hour virtual classes for 8 weeks and a 4-hour virtual retreat
* Practice specific activities in between classes for 20-30 minutes a day
* Answer survey questions before starting the intervention, half-way through the intervention, after the intervention, and 3-months after the intervention ends. Read Less
Gender:
ALL
Ages:
Between 18 years and 25 years
Trial Updated:
07/08/2025
Locations: N/A-- All study activities being conducted virtually, Providence, Rhode Island
N/A-- All study activities being conducted virtually, Providence, Rhode Island
Conditions: Healthy
Cognitive Control & the Functional Organization of the Frontal Cortex
Recruiting
The goal of this basic experimental clinical trial is to understand the effect of multitasking practice on the structure of neural representations of tasks in the human lateral prefrontal cortex and control brain regions. The main question it aims to answer is: What changes in neural representational structure predict improvements in multitasking behavior due to multitasking practice? Healthy human participants will learn two independent tasks, each mapping a set of stimuli to motor responses ba... Read More
The goal of this basic experimental clinical trial is to understand the effect of multitasking practice on the structure of neural representations of tasks in the human lateral prefrontal cortex and control brain regions. The main question it aims to answer is: What changes in neural representational structure predict improvements in multitasking behavior due to multitasking practice? Healthy human participants will learn two independent tasks, each mapping a set of stimuli to motor responses based on different rules. Participants will be randomized to one of two interventions. Participants assigned to the multitask practice intervention (MPI) will practice multitasking the two tasks over multiple days. Those assigned to the single-task practice intervention (SPI) will instead practice each task separately while controlling for the total number of practice opportunities associated with each task across the interventions. Both before and after the practice, the ability of all participants to perform both tasks simultaneously will be behaviorally measured using a well-established psychological refractory period (PRP) paradigm, and their neural representations will be measured using functional MRI while they perform the two tasks. Researchers will then compare improvements in multitasking behavior across the two groups, as well as changes in neural representational geometry of the tasks in the lateral prefrontal cortex and control brain regions, and test whether multitasking training is associated with specific changes in neural representations in the lateral prefrontal cortex. Read Less
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
08/12/2025
Locations: Metcalf Research Building, Brown University & MRI Research Facility, Brown University, Providence, Rhode Island
Metcalf Research Building, Brown University & MRI Research Facility, Brown University, Providence, Rhode Island
Conditions: Multitasking Behavior and Neural Representations Associated With Multitasking Ability, Healthy Volunteers, Executive Function
Generalization and Specificity of Visual Learning During Sleep
Recruiting
A growing body of evidence suggests that sleep facilitates and is beneficial to perceptual learning. However, the underlying mechanism of this facilitatory action is largely unknown. One must know what type of processing occurs during sleep to clarify the mechanism of sleep facilitating perceptual learning. For this purpose, investigators will obtain highly localized spatio-temporal information about brain activation during sleep using magnetic resonance imaging (MRI) and polysomnography (PSG) m... Read More
A growing body of evidence suggests that sleep facilitates and is beneficial to perceptual learning. However, the underlying mechanism of this facilitatory action is largely unknown. One must know what type of processing occurs during sleep to clarify the mechanism of sleep facilitating perceptual learning. For this purpose, investigators will obtain highly localized spatio-temporal information about brain activation during sleep using magnetic resonance imaging (MRI) and polysomnography (PSG) measurement. Read Less
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
08/01/2025
Locations: Brown University, Providence, Rhode Island
Brown University, Providence, Rhode Island
Conditions: Visual Learning, Healthy Volunteers
Medical Discoveries and Innovation in Rhode Island
Rhode Island research institutions continue to modernize and improve the healthcare field. Many of the innovations in medicine come from this state. Here is a list of some of the most impactful achievements.
- Treatment for opioid use: Brown University‘s medical school achieved a historic milestone. It became the first medical school in the country whose graduates all had the training necessary to prescribe meds for treating opioid use disorder.
- First kidney transplant: Dr. Robert W. Hopkins, did the first kidney transplant in the state on a young patient from Central Falls. Today, at Rhode Island Hospital, around 50 to 60 kidney transplant procedures are carried out annually. That includes 40% from living donors.
- Biomedical research: Rhode Island excels in biomedical innovation. There are thriving markets in areas like treatments for brain-related disorders, devices for orthopedics, and bio-sensing. This is revolutionizing how we identify and treat medical conditions.
Why Rhode Island Is A Great Place For Clinical Research
Clinical trials in Rhode Island thrive in a diverse environment. About 70.4% of its residents are White, 17.1% are Hispanic, 6.2% are Black, 3.5% are Asian, 2.2% are Multiracial, and 0.4% are American Indian.