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Clinical research in Indiana is a necessity. New medications, devices, and treatments have to be tested before they can be licensed and available on the market. Every year, hundreds of trials are launched that benefit the general public.
You too can be a health pioneer and apply for these trials. With your help, experts can drive medical progress and create a meaningful impact that can save lives.
Clinical Trials For Disease Areas in Indiana
Indiana has a diverse portfolio of clinical research trials. The state is renowned for its cardiology, cancer, infectious disease research, psychiatry, and pediatric care. It is here that many experts address pressing public health concerns and offer valuable knowledge.
In 2023, an Indiana woman celebrated 5 years since her clinical trial. Lana Boes is a cancer survivor who struggled with cervical cancer since 2008. The clinical trial of Keytruda gave her her life back. It offered a new type of treatment known as immunotherapy.
Your participation matters. Apply today.
Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer
Recruiting
This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage III-IV head and neck cancer the begins in the thin, flat cells (squamous cell). Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin and docetaxel, wor... Read More
This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage III-IV head and neck cancer the begins in the thin, flat cells (squamous cell). Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Cetuximab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The purpose of this study is to compare the usual treatment (radiation therapy with cisplatin chemotherapy) to using radiation therapy with docetaxel and cetuximab chemotherapy, and using the usual treatment plus an immunotherapy drug, atezolizumab. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: Ascension Saint Vincent Anderson, Anderson, Indiana +10 locations
Ascension Saint Vincent Anderson, Anderson, Indiana
Elkhart General Hospital, Elkhart, Indiana
Radiation Oncology Associates PC, Fort Wayne, Indiana
Parkview Hospital Randallia, Fort Wayne, Indiana
Parkview Regional Medical Center, Fort Wayne, Indiana
Goshen Center for Cancer Care, Goshen, Indiana
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
IU Health Methodist Hospital, Indianapolis, Indiana
IU Health Central Indiana Cancer Centers-East, Indianapolis, Indiana
Michiana Hematology Oncology PC-Mishawaka, Mishawaka, Indiana
Memorial Hospital of South Bend, South Bend, Indiana
Conditions: Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7, Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7, Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7, Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7, Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7, Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7, Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7, Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7, Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma
Prospective Research Assessment in Multiple Myeloma: An Observational Evaluation (PREAMBLE)
Recruiting
The purpose of this study is to assess the clinical effectiveness of all approved multiple myeloma (MM) therapies in the newly-diagnosed (NDMM) and the relapsed/refractory MM (RRMM) settings in real-world clinical practice.
The purpose of this study is to assess the clinical effectiveness of all approved multiple myeloma (MM) therapies in the newly-diagnosed (NDMM) and the relapsed/refractory MM (RRMM) settings in real-world clinical practice. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/28/2025
Locations: Local Institution - 0058, Anderson, Indiana +2 locations
Local Institution - 0058, Anderson, Indiana
Local Institution - 0011, Indianapolis, Indiana
Local Institution, Indianapolis, Indiana
Conditions: Multiple Myeloma
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer
Recruiting
The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming back.
The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming back. Read Less
Gender:
FEMALE
Ages:
35 years and above
Trial Updated:
06/10/2025
Locations: IU Health West Hospital, Avon, Indiana +9 locations
IU Health West Hospital, Avon, Indiana
IU Health North Hospital, Carmel, Indiana
UChicago Medicine Northwest Indiana, Crown Point, Indiana
IU Health Central Indiana Cancer Centers-Fishers, Fishers, Indiana
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
IU Health Methodist Hospital, Indianapolis, Indiana
Community Cancer Center East, Indianapolis, Indiana
Community Cancer Center South, Indianapolis, Indiana
Community Cancer Center North, Indianapolis, Indiana
IU Health Ball Memorial Hospital, Muncie, Indiana
Conditions: Breast Cancer
S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer
Recruiting
This phase III trial studies magnetic resonance imaging (MRI) surveillance and prophylactic cranial irradiation (PCI) to see how well they work compared to MRI surveillance alone in treating patients with small cell lung cancer. MRI scans are used to monitor the possible spread of the cancer with an MRI machine over time. PCI is radiation therapy that is delivered to the brain in hopes of preventing spread of cancer into the brain. The use of brain MRI alone may reduce side effects of receiving... Read More
This phase III trial studies magnetic resonance imaging (MRI) surveillance and prophylactic cranial irradiation (PCI) to see how well they work compared to MRI surveillance alone in treating patients with small cell lung cancer. MRI scans are used to monitor the possible spread of the cancer with an MRI machine over time. PCI is radiation therapy that is delivered to the brain in hopes of preventing spread of cancer into the brain. The use of brain MRI alone may reduce side effects of receiving PCI and prolong patients' lifespan. Monitoring with MRI scans alone (delaying radiation until the actual spread of the cancer) may be at least as good as the combination of PCI with MRI scans. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/20/2025
Locations: IU Health West Hospital, Avon, Indiana +10 locations
IU Health West Hospital, Avon, Indiana
IU Health North Hospital, Carmel, Indiana
Northwest Cancer Center - Main Campus, Crown Point, Indiana
Northwest Oncology LLC, Dyer, Indiana
Northwest Cancer Center - Hobart, Hobart, Indiana
Saint Mary Medical Center, Hobart, Indiana
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
IU Health Methodist Hospital, Indianapolis, Indiana
The Community Hospital, Munster, Indiana
Women's Diagnostic Center - Munster, Munster, Indiana
Northwest Cancer Center - Valparaiso, Valparaiso, Indiana
Conditions: Extensive Stage Lung Small Cell Carcinoma, Limited Stage Lung Small Cell Carcinoma, Lung Small Cell Carcinoma
Prospective Validation of a Points Score System Predicting 30-day Survival
Recruiting
This is a one-stage single-arm phase II clinical trial designed to prospectively test the survival prediction tool as developed by Lee et al on patients referred to radiation oncology for palliative treatments. Survival prediction score based on objective data including laboratory values, attendance to emergency room, and primary cancer origin will be assigned to each patient at time of enrollment.
This is a one-stage single-arm phase II clinical trial designed to prospectively test the survival prediction tool as developed by Lee et al on patients referred to radiation oncology for palliative treatments. Survival prediction score based on objective data including laboratory values, attendance to emergency room, and primary cancer origin will be assigned to each patient at time of enrollment. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2025
Locations: IU Health West, Avon, Indiana +2 locations
IU Health West, Avon, Indiana
IU Health North / Schwarz Cancer Center, Carmel, Indiana
Methodist Hospital, Indianapolis, Indiana
Conditions: Metastatic Cancer
Exercise in Metastatic Breast Cancer: EMBody
Recruiting
The purpose of this study is to study exercise in a novel population with indolent MBC (no progression on current therapy in prior 12 months and not receiving cytotoxic chemotherapy). The study team hypothesizes that delivering virtual, supervised, progressive intensity aerobic and resistance training exercise for 16 weeks in this population will significantly improve 1) cardiorespiratory fitness, functional status, and sarcopenia (low muscle mass), all established predictors of survival, and 2)... Read More
The purpose of this study is to study exercise in a novel population with indolent MBC (no progression on current therapy in prior 12 months and not receiving cytotoxic chemotherapy). The study team hypothesizes that delivering virtual, supervised, progressive intensity aerobic and resistance training exercise for 16 weeks in this population will significantly improve 1) cardiorespiratory fitness, functional status, and sarcopenia (low muscle mass), all established predictors of survival, and 2) patient- reported outcomes. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: IU Health West, Avon, Indiana +3 locations
IU Health West, Avon, Indiana
IU Health Joe and Shelly Schwarz Cancer Center, Carmel, Indiana
Indiana University Melvin & Bren Simon Cancer Center, Indianapolis, Indiana
Sidney and Lois Eskenazi Hospital, Indianapolis, Indiana
Conditions: Breast Cancer, Indolent Metastatic Breast Cancer
SKB264 in Combination With Pembrolizumab in Subjects With Selected Solid Tumors
Recruiting
The purpose of this study is to evaluate the efficacy and safety of combination of SKB264 and Pembrolizumab in patients with selected solid tumors including cervical cancer, urothelial cancer, ovarian cancer, prostate cancer,advanced endometrial cancer.
The purpose of this study is to evaluate the efficacy and safety of combination of SKB264 and Pembrolizumab in patients with selected solid tumors including cervical cancer, urothelial cancer, ovarian cancer, prostate cancer,advanced endometrial cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/16/2024
Locations: Community Clinical Research Center, Anderson, Indiana
Community Clinical Research Center, Anderson, Indiana
Conditions: Solid Tumor
Galleri® in the Medicare Population.
Recruiting
This multi-center comparative prospective cohort study is designed to assess the real world clinical impact, including safety and test performance, of Galleri®, a blood-based multi-cancer early detection (MCED) test. The study will seek to enroll approximately 20% of the study participants from under-represented minority populations (e.g., racial / ethnic minority groups, socioeconomically disadvantaged populations, rural populations).
This multi-center comparative prospective cohort study is designed to assess the real world clinical impact, including safety and test performance, of Galleri®, a blood-based multi-cancer early detection (MCED) test. The study will seek to enroll approximately 20% of the study participants from under-represented minority populations (e.g., racial / ethnic minority groups, socioeconomically disadvantaged populations, rural populations). Read Less
Gender:
ALL
Ages:
50 years and above
Trial Updated:
08/05/2025
Locations: Community Health Network Anderson, Anderson, Indiana +4 locations
Community Health Network Anderson, Anderson, Indiana
Community Health Network North, Fishers, Indiana
Community Health Network East, Indianapolis, Indiana
Community Health Network South, Indianapolis, Indiana
Community Health Network Kokomo, Kokomo, Indiana
Conditions: Cancer
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
Recruiting
The phase III trial compares the effect of pembrolizumab to observation for the treatment of patients with early-stage triple-negative breast cancer who achieved a pathologic complete response after preoperative chemotherapy in combination with pembrolizumab. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial may help researchers determine if observa... Read More
The phase III trial compares the effect of pembrolizumab to observation for the treatment of patients with early-stage triple-negative breast cancer who achieved a pathologic complete response after preoperative chemotherapy in combination with pembrolizumab. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial may help researchers determine if observation will result in the same risk of cancer coming back as pembrolizumab after surgery in triple-negative breast cancer patients who achieve pathologic complete response after preoperative chemotherapy with pembrolizumab. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/24/2025
Locations: IU Health West Hospital, Avon, Indiana +13 locations
IU Health West Hospital, Avon, Indiana
IU Health North Hospital, Carmel, Indiana
Northwest Cancer Center - Main Campus, Crown Point, Indiana
UChicago Medicine Northwest Indiana, Crown Point, Indiana
Northwest Oncology LLC, Dyer, Indiana
Northwest Cancer Center - Hobart, Hobart, Indiana
Saint Mary Medical Center, Hobart, Indiana
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
Sidney and Lois Eskenazi Hospital, Indianapolis, Indiana
Saint Catherine Hospital, Indianapolis, Indiana
The Community Hospital, Munster, Indiana
Women's Diagnostic Center - Munster, Munster, Indiana
Baptist Health Floyd, New Albany, Indiana
Northwest Cancer Center - Valparaiso, Valparaiso, Indiana
Conditions: Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Early Stage Triple-Negative Breast Carcinoma
Testing Low Dose Tamoxifen for Invasive Breast Cancer, the (LoTam) Trial
Recruiting
This phase III trial compares the effect of low dose tamoxifen to usual hormonal therapy, including aromatase inhibitors, in treating post-menopausal women with hormone positive, HER2 negative early stage breast cancer. Tamoxifen is in a class of medications known as antiestrogens. It blocks the activity of estrogen (a female hormone) in the breast. This may stop the growth of some breast tumors that need estrogen to grow. Aromatase inhibitors, such as anastrozole, letrozole, and exemestane, pre... Read More
This phase III trial compares the effect of low dose tamoxifen to usual hormonal therapy, including aromatase inhibitors, in treating post-menopausal women with hormone positive, HER2 negative early stage breast cancer. Tamoxifen is in a class of medications known as antiestrogens. It blocks the activity of estrogen (a female hormone) in the breast. This may stop the growth of some breast tumors that need estrogen to grow. Aromatase inhibitors, such as anastrozole, letrozole, and exemestane, prevent the formation of estradiol, a female hormone, by interfering with an aromatase enzyme. Aromatase inhibitors are used as a type of hormone therapy to treat postmenopausal women with hormone-dependent breast cancer. Giving low dose tamoxifen may be more effective compared to usual hormone therapy in treating post-menopausal women with hormone-positive, HER2 negative early stage breast cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/24/2025
Locations: IU Health West Hospital, Avon, Indiana +3 locations
IU Health West Hospital, Avon, Indiana
IU Health North Hospital, Carmel, Indiana
UChicago Medicine Northwest Indiana, Crown Point, Indiana
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
Conditions: Anatomic Stage 0 Breast Cancer AJCC V8, Anatomic Stage 1 Breast Cancer AJCC V8, Anatomic Stage IIA Breast Cancer AJCC V8, Estrogen Receptor-Positive Breast Carcinoma, HER2-Negative Breast Carcinoma
Paid Clinical Trials in Indiana
Experts are dedicated to providing solutions and advancing medicine. Paid clinical trials offer an incentive for those who participate. It means you can get paid for taking part in a trial. The compensation varies. It can come in the form of non-monetary and monetary benefits.
With monetary rewards, you can expect anywhere from $50 to $300 a day. IN paid clinical trials can also compensate you for the costs of travel, gas, and accommodation.
Clinical Trials For Health Volunteers in Indiana
As research teams in Indiana find new treatment methods, comes a need to have more health volunteers take part in clinical trials.
Every volunteer has the potential to revolutionize healthcare outcomes. Not only for themselves but for countless other patients who face similar challenges. If you want to be a part of medical progress, check the list below for active and future trials in your local area.
Integrated Cancer Repository for Cancer Research
Recruiting
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct characteristic of the iCaRe2 is its geographical coverage, with a significant percentage of small and rural hospitals and cancer centers. The iCaRe2 advances comprehensive studies of risk factors of cancer... Read More
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct characteristic of the iCaRe2 is its geographical coverage, with a significant percentage of small and rural hospitals and cancer centers. The iCaRe2 advances comprehensive studies of risk factors of cancer development and progression and enables the design of novel strategies for prevention, screening, early detection and personalized treatment of cancer. Centers with expertise in cancer epidemiology, genetics, biology, early detection, and patient care can collaborate by using the iCaRe2 as a platform for cohort and population studies. Read Less
Gender:
ALL
Ages:
Between 19 years and 110 years
Trial Updated:
06/04/2025
Locations: Parkview Research Center, Fort Wayne, Indiana +2 locations
Parkview Research Center, Fort Wayne, Indiana
Community Health Network, Indianapolis, Indiana
Community Cancer Center South, Indianapolis, Indiana
Conditions: Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer, Thymus Cancer, Colon Cancer, Rectal Cancer, Anal Cancer, Bile Duct Cancer, Duodenal Cancer, Gallbladder Cancer, Gastric Cancer, Liver Cancer, Small Intestine Cancer, Peritoneal Surface Malignancies, Familial Adenomatous Polyposis, Lynch Syndrome, Bladder Cancer, Kidney Cancer, Penile Cancer, Prostate Cancer, Testicular Cancer, Ureter Cancer, Urethral Cancer, Hypopharyngeal Cancer, Laryngeal Cancer, Lip Cancer, Oral Cavity Cancer, Nasopharyngeal Cancer, Oropharyngeal Cancer, Paranasal Sinus Cancer, Nasal Cavity Cancer, Salivary Gland Cancer, Skin Cancer, Mesothelioma, Breast Cancer, Leukemia, Melanoma, Sarcoma, Unknown Primary Tumor, Multiple Myeloma, Ovarian Cancer, Endometrial Cancer, Vaginal Cancer, Neuroendocrine Tumors, Plasma Cell Dyscrasia, Healthy Control, Gastrointestinal Stromal Tumors, Central Nervous System Tumor, Central Nervous System Cancer
Classroom Break, Cognition, and Fitness in Elementary School Children
Recruiting
The goal of this randomized controlled trial is to learn about the effect of a 12-week school-based intervention combining mindfulness with high-intensity interval training (MF-HIIT), MF-only intervention, and HIIT-only intervention in relative to sedentary activities on executive function (EF) in 8-12 years old children. The main question it aims to answer is whether a 12-week school-based MF-HIIT intervention has larger beneficial effect on EF performance than that following a 12-week school-b... Read More
The goal of this randomized controlled trial is to learn about the effect of a 12-week school-based intervention combining mindfulness with high-intensity interval training (MF-HIIT), MF-only intervention, and HIIT-only intervention in relative to sedentary activities on executive function (EF) in 8-12 years old children. The main question it aims to answer is whether a 12-week school-based MF-HIIT intervention has larger beneficial effect on EF performance than that following a 12-week school-based MF-only and HIIT-only in relative to the sedentary activities.
Multiple cohorts of participants will be recruited to participate this one-semester study, including the pretest, intervention, and posttest phases.
During the pretest phase, participants an their parents will complete the following
1. Kaufman Brief Intelligence Test (KBIT) to assess intelligence quotient
2. Fitnessgram test to assess aerobic capacity, muscle endurance, flexibility, and body mass index
3. Child and Adolescent Mindfulness Measure (CAMM) questionnaire to assess dispositional mindfulness
4. Computerized tasks to assess EF
5. Parent-reported demographic and health information
Following the pretest phase, participants will receive the 12-week classroom-based intervention, with the classroom as the intervention unit.
Following the intervention and during the posttest phase, participants will complete the fitness, measures, EF measures, and dispositional mindfulness measure again.
Researcher will compare the EFn outcome measures following the MF-HIIT, MF-only, and HIIT-only interventions with the sedentary activity intervention to see if MF and HIIT has beneficial effects on children's EF.
Further, researcher will compare the EF measures following the MF-HIIT compared with MF-only and HIIT-only interventions to see if combining MF with HIIT has greater beneficial effects on children's EF than MF and HIIT alone. Read Less
Gender:
ALL
Ages:
Between 8 years and 12 years
Trial Updated:
04/17/2025
Locations: Pioneer Elementary School, Royal Center, Indiana
Pioneer Elementary School, Royal Center, Indiana
Conditions: Healthy Volunteers
Acute Effects of High-intensity Interval Training With Mindfulness-based Recovery on Executive Function in Children
Recruiting
The goal of this randomized cross-over trial is to learn about the effect of a single bout of 20-min mindfulness-based high-intensity interval training (MF-HIIT), MF-only, and HIIT-only in relative to sitting rest on executive function (EF) in 10-12 years old children. The main question it aims to answer are:
Question 1: Whether a single bout of 20-min MF-HIIT has larger beneficial effect on EF performance than that following a 20-min session of MF-only and HIIT-only in relative to the sitting... Read More
The goal of this randomized cross-over trial is to learn about the effect of a single bout of 20-min mindfulness-based high-intensity interval training (MF-HIIT), MF-only, and HIIT-only in relative to sitting rest on executive function (EF) in 10-12 years old children. The main question it aims to answer are:
Question 1: Whether a single bout of 20-min MF-HIIT has larger beneficial effect on EF performance than that following a 20-min session of MF-only and HIIT-only in relative to the sitting rest
Question 2: Whether a single bout of 20-min MF-HIIT has a larger beneficial effect on brain functioning, as measured by the N2 and P3 components of event-related potential (ER) during EF performance than that following a 20-min session of MF-only and HIIT-only in relative to the sitting rest
Participants will visit the laboratory on 5 separate days (\> 2-day washout between days) in which they have not previously participated in structured physical activities.
Participants will complete the testing and/or receive treatments below:
Day 1:
* Kaufman Brief Intelligence Test (KBIT) to assess intelligence quotient
* Treadmill-based exercise test to measure cardiorespiratory fitness (maximum oxygen consumption)
Days 2-5
* Each day, participants will complete each of the four intervention conditions (MF-HIIT, MF-only, HIIT-only, sitting)
* Participants' heart rate and self-reported affect and rating of physical exertion will be measured
* Participants will complete a modified flanker task and a task-switching task to assess inhibitory control and cognitive flexibility
* Participants will wear an EEG cap to measure the N2 and P3 components of the event-related potential during the inhibitory control and cognitive flexibility performance
Researcher will compare the cognitive outcome measures following the MF-HIIT, MF-only, and HIIT-only conditions with the sitting condition to see if MF and HIIT has beneficial effects on children's EF.
Further, researcher will compare the cognitive outcome measures following the MF-HIIT compared with MF-only and HIIT-only conditions to see if combining MF with HIIT has greater beneficial effects on children's EF than MF and HIIT alone. Read Less
Gender:
ALL
Ages:
Between 10 years and 12 years
Trial Updated:
04/17/2025
Locations: Lambert, 800 West Stadium Avenue, West Lafayette, Indiana
Lambert, 800 West Stadium Avenue, West Lafayette, Indiana
Conditions: Healthy Volunteers
Acoustic Waveform Respiratory Evaluation
Recruiting
The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations.
The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations. Read Less
Gender:
ALL
Ages:
Between 8 years and 65 years
Trial Updated:
09/11/2024
Locations: Indiana University, Indianapolis, Indiana
Indiana University, Indianapolis, Indiana
Conditions: Asthma, COPD, Cystic Fibrosis, Ciliary Motility Disorders, Bronchiectasis, Airway Malacia, Healthy Control
Impact of Native Chicory Inulin on Change and Persistence of Gut Microbiota
Recruiting
The main aim of this study is to investigate differences in rate, extent of change and persistence of the gut microbiota in healthy adult volunteers in response to native chicory inulin. Along with investigating the impact of native chicory on bowl habits, mood and appetite. The two main questions this study aims to answer:
* To what extent do differences exist in rate of change over time between individuals in gut microbiota response (Bifidobacterium growth) to native chicory inulin supplement... Read More
The main aim of this study is to investigate differences in rate, extent of change and persistence of the gut microbiota in healthy adult volunteers in response to native chicory inulin. Along with investigating the impact of native chicory on bowl habits, mood and appetite. The two main questions this study aims to answer:
* To what extent do differences exist in rate of change over time between individuals in gut microbiota response (Bifidobacterium growth) to native chicory inulin supplementation.
* To what extent do differences exist between individuals in persistence of the gut microbiota upon stopping supplementation.
The effects of native chicory inulin on gut microbiota response will be compared to a maltodextrin placebo to sure changes in gut microbiota result directly from chicory inulin supplementation.
Participants will firstly complete a one-week run-in phase to establish baseline data and will then be allocated to either native chicory inulin or maltodextrin supplementation for 6 weeks. Inulin will be delivered at 12 g/day split into 2 x 6g portions. Maltodextrin will be calorie matched at 6 g/day split into 2 x 3g portions. This will then be followed by a 6 week post-supplementation phase. Fecal and blood samples will be collected regularly throughout all phases for analysis of gut microbiota and compounds of interest. Participants will also record any changes in gastrointestinal sensation, bowel habits and mood in a diary. Changes in appetite sensation will also measured. Read Less
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
08/01/2024
Locations: Purdue University, West Lafayette, Indiana
Purdue University, West Lafayette, Indiana
Conditions: Healthy
Effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Plasma Insulin Levels
Recruiting
The purpose of this study is to find out if investigators can stimulate the vagus nerve (a nerve in the body that runs from your brain to the large intestine), and influence insulin, C-peptide, and glucose levels. C-peptide is a substance that is created when insulin is produced and released into the body. The vagus nerve is a largely internal nerve that controls many bodily functions, including stomach function.
Investigators hope that by stimulating the vagal nerve using the TeNS behind the e... Read More
The purpose of this study is to find out if investigators can stimulate the vagus nerve (a nerve in the body that runs from your brain to the large intestine), and influence insulin, C-peptide, and glucose levels. C-peptide is a substance that is created when insulin is produced and released into the body. The vagus nerve is a largely internal nerve that controls many bodily functions, including stomach function.
Investigators hope that by stimulating the vagal nerve using the TeNS behind the ear, this stimulation can affect insulin levels, and this will help innovate treatment of patients with nausea, vomiting, and disordered stomach function, and patients with diabetes.
Researchers hope to be able to measure the activity of the vagus nerve when it is stimulated in other ways. This could help investigators learn more about studying this nerve in the future. Read Less
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/23/2025
Locations: Indiana University Hospital, Indianapolis, Indiana
Indiana University Hospital, Indianapolis, Indiana
Conditions: Healthy
Glycemic/Insulinemic Effects of Fresh Mango as a Sugar Substitute in Realistic Breakfasts.
Recruiting
Large blood sugar and insulin increases after meals high in table sugar are related to risk for diabetes and heart disease. Additionally, large increases in blood sugar may also negatively impact vascular health. Previous research suggests that mango consumed in small quantities has blood sugar-lowering properties, but the evidence of this within larger, more realistic meals is limited. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which als... Read More
Large blood sugar and insulin increases after meals high in table sugar are related to risk for diabetes and heart disease. Additionally, large increases in blood sugar may also negatively impact vascular health. Previous research suggests that mango consumed in small quantities has blood sugar-lowering properties, but the evidence of this within larger, more realistic meals is limited. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to more favorable blood sugar, insulin, and vascular responses after eating breakfast meals. The investigators will compare the postprandial glycemic, insulinemic, and vascular response to low and high glycemic meals sweetened with either fresh mango or sucrose. Read Less
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
06/24/2025
Locations: Health Professions Building, Ball State University, Muncie, Indiana
Health Professions Building, Ball State University, Muncie, Indiana
Conditions: Healthy Participants
Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes
Recruiting
Based on prior research, the investigators are interested in whether an intervention targeting gut health (supplemental fiber for 9 weeks total) will improve vascular health in individuals with obesity. Additionally, the investigators are interested in if this response differs based on whether individuals with obesity have very few heart disease risk factors or several heart disease risk factors.
Based on prior research, the investigators are interested in whether an intervention targeting gut health (supplemental fiber for 9 weeks total) will improve vascular health in individuals with obesity. Additionally, the investigators are interested in if this response differs based on whether individuals with obesity have very few heart disease risk factors or several heart disease risk factors. Read Less
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
07/24/2025
Locations: Health Professions Building, Muncie, Indiana
Health Professions Building, Muncie, Indiana
Conditions: Metabolic Syndrome, Healthy Participants, Metabolically Healthy Obesity, Metabolically Abnormal Obesity
Medical Discoveries and Innovation in Indiana
Indiana research institutions and medical facilities strive to improve patient care. Every contribution, study, and trial, helps benefit the global healthcare landscape. Here are some of the most notable advancements made in the area.
- Sepsis Research: Across the state of Indiana, medical communities are using new methods and very advanced equipment in their surgeries. About 30 IN hospitals take part in sepsis simulations that provide them with hands-on experience. The research can help improve the survival rate of septic shock patients.
- Spine Surgery Advancements: Franciscan Health Dyer in Indiana is using 3D imaging in spine surgeries. This CT technique reduced recovery rates in patients with complex and simple spine cases. Thanks to 3D imaging, there were no infections in 236 of the procedures performed in 2020.
- Rural Hospitals Are Using High-Tech: Medical facilities in Indiana, like Decatur County Memorial Hospital, went through a major upgrade to their telehealth systems and monitoring technology. This helped reduce readmission rates, and unnecessary visits, and boost patient care for chronic diseases.
Why Indiana Is A Great Place For Clinical Research
People of different ethnicities and racial makeup live in Indiana. This makes the area a solid option for clinical research. About 77.5% of its residents are White, 9.8% are Black, 7.7% are Hispanic, 2.7% are Asian, and 2.1% are Multiracial.