Paid Clinical Trials in Massachusetts

Candace Kastanis

Written by Candace Kastanis

Chemistry B.S. | UC Davis | Clinical Lab Technician

Updated & Fact Checked 3/07/23

Research Opportunities in Massachusetts

Paid Clinical Trials in Massachusetts

Since the earliest years of America, Boston has been a trendsetter; and the population of greater Massachusetts has been in expansion for decades. Culture and science have a home in Massachusetts, and if you’re seeking paid clinical trials for healthy volunteers nearby, there are options.

Several points of data help triangulate what kind of opportunities to expect in the state. You want to look at the population of Massachusetts, the rate of experimentation necessary nationwide to maintain progressive medical advancement, and how many known vendors are in the state. This will help give you a ballpark “average” of the sort of opportunities you can find in the state.

Experts say 1 in 200 Americans, or .005%, need to be involved in clinical studies at all times. There are 7,126,375 people in Massachusetts, and approximately 1,102 vendors offering clinical research opportunities; though there is some crossover between adjacent states, as some companies have multiple labs being managed under their funding.
What this indicates is, you can expect approximately 32 individual opportunities per vendor. Some vendors will have studies that require 500 participants, some will only need a handful; so that number will vary. On average, though, expect a few dozen opportunities per vendor. Here we’ll explore a little more information to help you narrow down your search.

Demographic Data Helps Show Trial Availability in Massachusetts

Figuring out which paid clinical trials nearby for healthy volunteers you’ll be eligible for can be difficult, but remember that generally, labs must work with what’s available. Accordingly, many studies will be calibrated to fit communities that will have volunteers in a certain category. In Massachusetts, 76.56% of the population is white, 7.47% is black, 6.78% is Asian, and 4.78% of the population is 2 or more races. The median age of the state is 38. 51.46% of the population is female, and 48.54% are male.

We have compiled the following list of paid clinical trials for healthy volunteers, click the Search All button at the bottom to find more:

Mapping Auricular Vagus Nerve Circuitry
Recruiting
This study will determine how noninvasive nerve stimulation affects human brain, stomach, and autonomic activity.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/22/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Healthy
Collection and Distribution of Biospecimens for Novel Research Uses
Recruiting
iSpecimen aims to create a clinical partner network of hospitals, laboratories, academic institutions, and other healthcare organizations ("institutions") capable of providing researchers and educators ("researchers") with annotated biospecimens for use in biomarker discovery and validation; diagnostic test and instrumentation development and validation; therapeutics development; other medical research including the impact that various specimen collection and handling methods and conditions have... Read More
Gender:
ALL
Ages:
Between 1 month and 89 years
Trial Updated:
11/08/2022
Locations: iSpecimen, Lexington, Massachusetts
Conditions: Cancer, Healthy, Gastrointestinal Complication, Autoimmune Diseases, Infectious Disease, Women's Health: High-Risk Pregnancy, Dermatologic Disease, Blood Disease
Personalized Responses to Dietary Composition Trial 3
Recruiting
The PREDICT 3 study will build on previous research in over 2,000 individuals to further refine machine learning models that predict individual responses to foods, with the aim of advancing precision nutrition science and individualized dietary advice. The study incorporates both standardized and controlled dietary intervention, for the purpose of testing postprandial responses to specific mixed meals, in addition to a free-living period with a dietary record for measuring responses to a large v... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Zoe US Inc., Needham, Massachusetts
Conditions: Diabetes, Heart Diseases, Diet Habit, Diet Modification, Healthy, Obesity, Metabolism, Microbial Colonization
The Accuracy of a Novel Platelet Activity Assay in Humans on Antiplatelet Agents: Pharmacodynamics and Comparison with Light Transmission Aggregometry
Recruiting
The purpose of this study is to test a novel diagnostic immunoassay of platelet function and compare it to the current gold standard platelet function assay by testing the response to aspirin and clopidogrel in a group of healthy volunteers and severely obese individuals and comparing the accuracy of the two tests. The secondary goals will be to evaluate the pharmacodynamic parameters of the antiplatelet agents across the two testing modalities and refine the cutoffs used for the novel assay.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/21/2025
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Platelet Activation Testing Before/After Anti-platelet Therapy, Healthy
Comparison of Cuff-Less Wrist Wearable Blood Pressure Device to Cuff Based Blood Pressure Measuring Devices
Recruiting
(1) To compare cuff-less wrist wearable radial artery blood pressure measurements utilizing ViTrack(developed by Dynocardia) to the cuff based commercially available blood pressure device, in healthy volunteers with normal or high blood pressure.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
08/05/2024
Locations: Dynocardia Inc, Newton, Massachusetts
Conditions: Hypertension, Healthy
Imaging Brain Fluids During Breathing
Recruiting
This study will perform magnetic resonance imaging (MRI) measurements of hemodynamics and cerebrospinal fluid flow across breathing tasks and during breath-locked neuromodulation.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/14/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Healthy
Causal Role of Brain Networks in Episodic Memory
Recruiting
The goal of this study is to understand the basic brain mechanisms supporting episodic memory in healthy young adults. Transcranial magnetic stimulation will be used to influence brain activity in regions thought to be important for episodic memory. Behavioral testing and MRI will be used to measure the effects of stimulation on memory and on changes in brain network interactions, allowing us to draw causal inferences regarding the role of specific brain regions in memory processes.
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
04/14/2025
Locations: Boston College, Chestnut Hill, Massachusetts
Conditions: Episodic Memory, Healthy
Effects of MIB-626 With and Without A High-Intensity Multi-Dimensional Exercise Training Program
Recruiting
A single-center, randomized, placebo-controlled study in community dwelling, healthy, regularly exercising, highly physically fit men and women, 19 to 40 years. Eligible participants will be randomized to receive either 1000 mg NMN or placebo twice daily for 10 weeks.
Gender:
ALL
Ages:
Between 19 years and 40 years
Trial Updated:
11/01/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Healthy
REcovery From DEXmedetomidine-induced Unconsciousness
Recruiting
This pilot study in healthy volunteers aims to determine if biological sex has an impact on recovery from dexmedetomidine-induced unconsciousness, and if transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) can be used to measure brain complexity during dexmedetomidine sedation without arousing study participants.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/13/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Anesthesia, Healthy, Consciousness, Level Altered
A Comparative Clinical Study to Assess Pain Score and Wound Healing Following Fractional Ablation With a DFG Laser and CO2 Laser
Recruiting
This research study aims assess whether the Difference Frequency Generation (DFG) laser could be a better alternative to the CO2 laser in terms of reduced side effects and patient downtime.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: MGH Clinical Unit for Research Trials & Outcomes in Skin, Boston, Massachusetts
Conditions: Healthy

Interpreting Massachusetts Diversity Data to Find Paid Trials

What this information indicates is that the lion’s share of paid clinical trials for healthy volunteers will be for white ladies in their late thirties, followed by men in a similar category, then those of African or Asian descent. Keep in mind, that studies for people of all ethnic backgrounds will be available given the size of the region. In fact, being in a niche category could make you more eligible for some studies.


Massachusetts CROs With Opportunities for Healthy Participants

With over 30k individual opportunities in Massachusetts, it can be hard to narrow down which healthy volunteer paid clinical trials you’re interested in volunteering for. Here are a few to consider if you’re not sure where to start; we’ve sourced them from all over the state:


Notable Medical Breakthroughs in Massachusetts

Being involved in clinical trials that advance medical science puts you in the driver’s seat of history. Well, in the passenger seat at least. Either way, you’re part of changing the world for the better. Here are some famous breakthroughs Massachusetts is known for:


Massachusetts CRO Trial Opportunities Are Out There For You

If you’re in Massachusetts and you’re interested in supplementing your income while making a historical contribution to society, there are options for you. All across the state, thousands of opportunities exist. Odds are, there’s something within a few miles of where you live; especially if you’re in Boston. If you can get paid to change the world for the good, that’s going to be a win for everyone.