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Clinical Trials For Disease Areas in Arizona
As a leader in clinical research and cutting-edge medical advancements, Arizona has become the epicenter for groundbreaking studies that shape the future of healthcare.
The state’s renowned research institutions, top-tier universities, and world-class healthcare facilities help create superior research teams. These researchers don’t just follow trends; they define them.
Arizona stands as a powerhouse of research strengths. Here, experts work to unravel components of common and complex diseases. With a particular emphasis on oncology, neurology, cardiology, and infectious diseases.
The critical nature of healthcare demands immediate solutions. That’s because many patients can’t wait six months or a year for a trial.
Arizona Oncology, for example, has access to some of the most exceptional trials in the world, stated Lisa Holland, the Vice President of US Oncology Research. The organization opens clinical research trials in Arizona quickly and can give fast access to those in need.
Here is a curated list of ongoing and upcoming trials.
A Study of Guselkumab Administered Subcutaneously in Bio-naive Participants With Active Psoriatic Arthritis Axial Disease
Recruiting
The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) axial disease by assessing reduction in axial symptoms and inflammation.
The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) axial disease by assessing reduction in axial symptoms and inflammation. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Arizona Arthritis and Rheumatology Research PLLC, Avondale, Arizona +5 locations
Arizona Arthritis and Rheumatology Research PLLC, Avondale, Arizona
Arizona Arthritis & Rheumatology Research, PLLC, Chandler, Arizona
Arizona Arthritis and Rheumatology Research PLLC, Mesa, Arizona
Arizona Arthritis Research, PLC., Phoenix, Arizona
Arizona Arthritis and Rheumatology Associates, Sun City, Arizona
Southern Arizona VA Healthcare System, Tucson, Arizona
Conditions: Arthritis, Psoriatic
SAVE-FistulaS: the SelfWrap-Assisted ArterioVEnous Fistulas Study
Recruiting
This is a prospective, randomized, multi-center clinical trial for chronic kidney disease (CKD) patients referred for creation of a new arteriovenous fistula (AVF) in order to assess the safety and effectiveness of SelfWrap, a bioabsorbable perivascular wrap.
This is a prospective, randomized, multi-center clinical trial for chronic kidney disease (CKD) patients referred for creation of a new arteriovenous fistula (AVF) in order to assess the safety and effectiveness of SelfWrap, a bioabsorbable perivascular wrap. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: AKDHC Bullhead City, Bullhead City, Arizona +3 locations
AKDHC Bullhead City, Bullhead City, Arizona
AKDHC Marana Surgery Center, Marana, Arizona
Arizona Kidney Disease & Hypertension Centers (AKDHC) Phoenix Surgery Center, Phoenix, Arizona
Banner University Medical Center, Tucson, Arizona
Conditions: Chronic Kidney Diseases, End Stage Renal Disease, Arteriovenous Fistula, Hemodialysis Access Failure, ESRD, Vascular Access Complication, Renal Failure, Catheter Complications, Catheter Dysfunction, Renal Insufficiency
Open-label, Long-term Safety Study of Secukinumab in Polymyalgia Rheumatica (PMR)
Recruiting
The purpose of this extension study is to assess the safety and tolerability of secukinumab when administered long-term in patients with polymyalgia rheumatica.
The purpose of this extension study is to assess the safety and tolerability of secukinumab when administered long-term in patients with polymyalgia rheumatica. Read Less
Gender:
ALL
Ages:
Between 50 years and 100 years
Trial Updated:
07/28/2025
Locations: Arizona Arthritis and Rheumatology Associates PLLC, Avondale, Arizona +1 locations
Arizona Arthritis and Rheumatology Associates PLLC, Avondale, Arizona
Sun Valley Arthritis Center Ltd, Peoria, Arizona
Conditions: Polymyalgia Rheumatica
Efficacy & Safety of Olvimulogene Nanivacirepvec & Platinum-doublet + Physician's Choice of Immune Checkpoint Inhibitor Compared to Docetaxel in NSCL Cancer
Recruiting
This Phase 2, open-label, randomized study in non-small-cell lung cancer (NSCLC) is designed to evaluate the efficacy and safety of an intravenously delivered oncolytic vaccinia virus, Olvi-Vec, followed by platinum-doublet chemotherapy + Physician's Choice of Immune Checkpoint Inhibitor (ICI) vs. docetaxel for patients with advanced or metastatic NSCLC who have shown first disease progression (i.e., progressive disease not yet confirmed by further scan after initial scan showing progression) wh... Read More
This Phase 2, open-label, randomized study in non-small-cell lung cancer (NSCLC) is designed to evaluate the efficacy and safety of an intravenously delivered oncolytic vaccinia virus, Olvi-Vec, followed by platinum-doublet chemotherapy + Physician's Choice of Immune Checkpoint Inhibitor (ICI) vs. docetaxel for patients with advanced or metastatic NSCLC who have shown first disease progression (i.e., progressive disease not yet confirmed by further scan after initial scan showing progression) while on front-line treatment or maintenance ICI therapy after front-line treatment with platinum-doublet chemotherapy + ICI as standard of care. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2025
Locations: Pioneer Research Center, LLC, Bullhead City, Arizona
Pioneer Research Center, LLC, Bullhead City, Arizona
Conditions: Advanced Non-squamous Non-small-cell Lung Cancer, Advanced Squamous Non-Small Cell Lung Carcinoma, Metastatic Non-squamous Non Small Cell Lung Cancer, Metastatic Squamous Non-Small Cell Lung Carcinoma, Non-small Cell Lung Cancer, Non-small Cell Lung Cancer Stage III, Non-small Cell Lung Cancer Stage IV, Non-small Cell Lung Cancer Recurrent
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupus Erythematosus
Recruiting
Phase 1b, open-label study of CLN-978 administered subcutaneously in patients with Moderate to Severe Systemic Lupus Erythematosus (SLE).
Phase 1b, open-label study of CLN-978 administered subcutaneously in patients with Moderate to Severe Systemic Lupus Erythematosus (SLE). Read Less
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/26/2025
Locations: Cullinan Investigative Site, Avondale, Arizona +1 locations
Cullinan Investigative Site, Avondale, Arizona
Cullinan Investigative Site, Tucson, Arizona
Conditions: SLE, SLE (Systemic Lupus)
A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
Recruiting
The purpose of this study is to evaluate the ability of dapirolizumab pegol (DZP) as an add-on treatment to standard of care (SOC) medication to achieve clinically relevant long term improvement of moderate to severe disease activity.
The purpose of this study is to evaluate the ability of dapirolizumab pegol (DZP) as an add-on treatment to standard of care (SOC) medication to achieve clinically relevant long term improvement of moderate to severe disease activity. Read Less
Gender:
ALL
Ages:
16 years and above
Trial Updated:
08/07/2025
Locations: Sl0044 50058, Avondale, Arizona +4 locations
Sl0044 50058, Avondale, Arizona
Sl0044 50550, Chandler, Arizona
Sl0044 50713, Gilbert, Arizona
Sl0044 50662, Glendale, Arizona
Sl0044 50052, Phoenix, Arizona
Conditions: Systemic Lupus Erythematosus
Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis Naive to Biologic Disease-Modifying Antirheumatic Drug
Recruiting
This is a study to demonstrate the clinical efficacy and safety of sonelokimab administered subcutaneously compared with placebo in the treatment of adult patients with active psoriatic arthritis who are naive to biologic disease-modifying antirheumatic drug therapy.
This is a study to demonstrate the clinical efficacy and safety of sonelokimab administered subcutaneously compared with placebo in the treatment of adult patients with active psoriatic arthritis who are naive to biologic disease-modifying antirheumatic drug therapy. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Clinical Site, Avondale, Arizona +6 locations
Clinical Site, Avondale, Arizona
Clinical Site, Chandler, Arizona
Clinical Site, Flagstaff, Arizona
Clinical Site, Mesa, Arizona
Clinical Site, Phoenix, Arizona
Clinical Site, Scottsdale, Arizona
Clinical Site, Tucson, Arizona
Conditions: Arthritis, Psoriatic
Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate Response
Recruiting
This is a study to confirm the clinical efficacy and safety of sonelokimab compared with placebo in the treatment of adults with active psoriatic arthritis who have had a previous inadequate response or intolerance to anti-tumor necrosis factor (TNF)α therapy.
This is a study to confirm the clinical efficacy and safety of sonelokimab compared with placebo in the treatment of adults with active psoriatic arthritis who have had a previous inadequate response or intolerance to anti-tumor necrosis factor (TNF)α therapy. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Clinical Site, Avondale, Arizona +6 locations
Clinical Site, Avondale, Arizona
Clinical Site, Chandler, Arizona
Clinical Site, Flagstaff, Arizona
Clinical Site, Mesa, Arizona
Clinical Site, Phoenix, Arizona
Clinical Site, Scottsdale, Arizona
Clinical Site, Tucson, Arizona
Conditions: Arthritis, Psoriatic
A Study of LY3541860 in Adult Participants With Moderately to Severely Active Rheumatoid Arthritis
Recruiting
The main purpose of this study is to evaluate the effects of LY3541860 in adult participants with moderately to severely active Rheumatoid Arthritis with inadequate response to a least one biologic disease-modifying antirheumatic drug (bDMARD)or targeted synthetic disease-modifying antirheumatic drug (tsDMARD).
Study participation is approximately 50 weeks, including a 6-week screening period, 24-week treatment period, and a 20-week safety follow up period.
The main purpose of this study is to evaluate the effects of LY3541860 in adult participants with moderately to severely active Rheumatoid Arthritis with inadequate response to a least one biologic disease-modifying antirheumatic drug (bDMARD)or targeted synthetic disease-modifying antirheumatic drug (tsDMARD).
Study participation is approximately 50 weeks, including a 6-week screening period, 24-week treatment period, and a 20-week safety follow up period. Read Less
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/24/2025
Locations: AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Avondale, Avondale, Arizona +5 locations
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Avondale, Avondale, Arizona
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Flagstaff, Flagstaff, Arizona
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Mesa, Mesa, Arizona
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Phoenix PV, Phoenix, Arizona
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Sun City, Sun City, Arizona
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Tucson Southeast, Tucson, Arizona
Conditions: Rheumatoid Arthritis
A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)
Recruiting
The main purpose of this study is to assess the effectiveness of adding tirzepatide to ixekizumab therapy in standard clinical practice in participants with moderate-to-severe PsA and obesity or overweight with at least 1 weight-related comorbidity.
The study will last up to 12 months.
The main purpose of this study is to assess the effectiveness of adding tirzepatide to ixekizumab therapy in standard clinical practice in participants with moderate-to-severe PsA and obesity or overweight with at least 1 weight-related comorbidity.
The study will last up to 12 months. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/17/2025
Locations: AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Avondale, Avondale, Arizona +9 locations
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Avondale, Avondale, Arizona
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Chandler, Chandler, Arizona
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Flagstaff, Flagstaff, Arizona
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Gilbert, Gilbert, Arizona
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Glendale, Glendale, Arizona
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Mesa, Mesa, Arizona
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Phoenix PV, Phoenix, Arizona
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Sun City, Sun City, Arizona
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Tucson, Tucson, Arizona
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Tucson Southeast, Tucson, Arizona
Conditions: Psoriatic Arthritis, Overweight or Obesity
Paid Clinical Trials in Arizona
Paid clinical trials in Arizona are some of the most practical and efficient ways of collecting data. Every year, millions of people volunteer in clinical trials. More than 90% of healthy clinical trial volunteers claim that money is their prime motivator for participating.
There are a variety of ways in which people are compensated for trial participation, but make sure to check with each trial individually to learn what the compensation options are.
Click here for Arizona clinical trials in Phoenix and Tucson
Clinical Trials For Health Volunteers in Arizona
At the heart of every medical breakthrough, are volunteers. These are remarkable individuals who’ve decided to offer valuable results that can help research teams in Arizona better compare and understand a wide range of medical complications.
These trial listings offer a chance for people to be a part of something transformative.
Developing Biomarkers of Dietary Intake: Dose Dependent Measurement of Sugar Intake
Recruiting
Background:
Diet is one of the most modifiable behaviors affecting health. But diet assessment measures that are based on self-report can be inaccurate. Researchers want better ways to address the role of diet in chronic disease. They want to see if stable isotopes can be used to better assess what people eat.
Objective:
To see if stable isotopes can help scientists identify things people eat.
Eligibility:
Healthy adults ages 18 to 65
Design:
Participants will be screened with a medical h... Read More
Background:
Diet is one of the most modifiable behaviors affecting health. But diet assessment measures that are based on self-report can be inaccurate. Researchers want better ways to address the role of diet in chronic disease. They want to see if stable isotopes can be used to better assess what people eat.
Objective:
To see if stable isotopes can help scientists identify things people eat.
Eligibility:
Healthy adults ages 18 to 65
Design:
Participants will be screened with a medical history and physical exam. They will have blood and urine tests. These tests will be repeated during the study.
Participants will stay in the inpatient unit of the NIH in Phoenix, Arizona, for 13 weeks.
For 7 days, participants will eat a diet prepared by the NIH kitchen. They will get balanced meals that are 50% carbohydrates, 20% protein, and 30% fat. Then participants will be randomly placed on one of 3 diets containing different percentages of carbohydrates from soda.
Participants height and weight will be measured. The amount of fat and muscle in their body will be measured by body scans that are similar to x-rays.
Participants will have oral glucose tolerance tests. They will consume a sugar drink and then give blood samples over 3 hours.
Participants will give hair and stool samples.
Participants will complete a diet questionnaire. It assesses their food intake over 24 hours.
Participants will complete behavioral questionnaires and computer performance tests.
Participants will have fat biopsies taken from their stomach and thigh.
Participants will have three 24-hour stays in a metabolic chamber. It is used to measure metabolism. Read Less
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/31/2025
Locations: NIDDK, Phoenix, Phoenix, Arizona
NIDDK, Phoenix, Phoenix, Arizona
Conditions: Diet Therapy, Healthy Volunteers
A Study to Evaluate the Impact of Lactobacillus Rhamnosus GG on Proton Pump Inhibitor-Induced Gut Dysbiosis
Recruiting
The purpose of this study is to investigate the impact of the probiotic Lactobacillus rhamnosus (LGG) on proton pump inhibitor (PPI)-induced changes to the microbes that live in the gastrointestinal tract and are passed out in the stool. PPI medicines reduce stomach acid and are commonly used to treat acid reflux disease.
The purpose of this study is to investigate the impact of the probiotic Lactobacillus rhamnosus (LGG) on proton pump inhibitor (PPI)-induced changes to the microbes that live in the gastrointestinal tract and are passed out in the stool. PPI medicines reduce stomach acid and are commonly used to treat acid reflux disease. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2025
Locations: Mayo Clinic Arizona, Scottsdale, Arizona
Mayo Clinic Arizona, Scottsdale, Arizona
Conditions: Healthy
The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure
Recruiting
Background:
Diet-induced thermogenesis (DIT) is the amount of energy one s body uses to eat food, absorb the nutrients from the food, and process those nutrients. Researchers would like to understand more about how changing the balances of protein, fat, carbohydrates, and total calories in the diet can affect DIT.
Objective:
To learn how different diets can change a person s DIT.
Eligibility:
Healthy people aged 18 to 60 years who have not intentionally lost weight in the past 6 months.
De... Read More
Background:
Diet-induced thermogenesis (DIT) is the amount of energy one s body uses to eat food, absorb the nutrients from the food, and process those nutrients. Researchers would like to understand more about how changing the balances of protein, fat, carbohydrates, and total calories in the diet can affect DIT.
Objective:
To learn how different diets can change a person s DIT.
Eligibility:
Healthy people aged 18 to 60 years who have not intentionally lost weight in the past 6 months.
Design:
Participants will stay in a clinic for about 35 days. They will eat only the food provided. They will receive 8 different diets during the study, including 7 test diets.
Participants will undergo multiple tests.
They will be screened with blood and urine tests and a test of their heart function.
During the first few days:
Their waist, thigh, and neck circumference will be measured.
They will have a DXA scan: They will lie on a padded table for about 20 minutes while an instrument measures the amount of fat in their body.
They will be tested for diabetes.
They will answer questionnaires about topics including eating behavior, hunger, and stress.
Throughout the study:
Their weight will be measured daily.
Blood tests will be repeated.
They will stay in a metabolic chamber a total of 9 times. They will remain in a closed room for 24 hours while researchers monitor the room temperature and levels of oxygen and carbon dioxide. Participants will collect all their urine for each 24-hour period.
... Read Less
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
07/31/2025
Locations: NIDDK, Phoenix, Phoenix, Arizona
NIDDK, Phoenix, Phoenix, Arizona
Conditions: Obesity, Normal Physiology, Healthy Volunteers
A Study of Neurodegeneration and Neuronal Fluctuations in Lewy Body Disease and Alzheimer's Disease
Recruiting
The purpose of this research study is to investigate how the brain, memory, thinking, and motor behavior change both in individuals with movement and/or cognitive disorders, as well as healthy individuals. Researchers will look at measurements of memory, thinking, brain wave and muscle activity, daily functioning, and brain scans to learn more about brain disorders such as Alzheimer disease and Lewy body disease.
The purpose of this research study is to investigate how the brain, memory, thinking, and motor behavior change both in individuals with movement and/or cognitive disorders, as well as healthy individuals. Researchers will look at measurements of memory, thinking, brain wave and muscle activity, daily functioning, and brain scans to learn more about brain disorders such as Alzheimer disease and Lewy body disease. Read Less
Gender:
ALL
Ages:
Between 50 years and 95 years
Trial Updated:
01/27/2025
Locations: Mayo Clinic Arizona, Scottsdale, Arizona
Mayo Clinic Arizona, Scottsdale, Arizona
Conditions: Lewy Body Disease, Alzheimer Disease, Healthy
Variability In Mixed Meal Tests: Fixed Versus Adjusted to Energy Needs Caloric Dose
Recruiting
Background:
Researchers use mixed meal tolerance tests (MMTTs) to look at how people s bodies respond to eating a meal. However, researchers do not agree on how to decide the number of calories to give in each meal. Some use fixed meals, which are the same size for everyone, and some use adjusted meals, based on the size of the person s body. Researchers want to know which MMTT is best to use for future research.
Objective:
To learn how fixed vs adjusted meals affect blood glucose levels in h... Read More
Background:
Researchers use mixed meal tolerance tests (MMTTs) to look at how people s bodies respond to eating a meal. However, researchers do not agree on how to decide the number of calories to give in each meal. Some use fixed meals, which are the same size for everyone, and some use adjusted meals, based on the size of the person s body. Researchers want to know which MMTT is best to use for future research.
Objective:
To learn how fixed vs adjusted meals affect blood glucose levels in healthy people.
Eligibility:
Healthy people aged 18 years or older.
Design:
Participants will have 3 or 4 clinic visits of up to 8 hours in 8 weeks.
Participants will have baseline tests:
Their height, weight, and waist size will be measured.
They will have an oral glucose tolerance test: A needle attached to a tube (IV) will be inserted into a vein in the arm. They will have a sugary drink. Blood samples will be taken from the tube at intervals up to 3 hours after the drink.
They will have a body scan.
Participants will have 2 MMTT visits. One will include a fixed meal and one will include an adjusted meal. They will have tests at both visits:
Resting metabolic rate: A clear hood will be placed over the participant s head while they rest for 20 minutes. This will measure the oxygen they breathe in and out.
MMTT. Participants will have 5 minutes to drink a liquid meal. Blood samples will be taken at intervals for the next 4 hours.... Read Less
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
07/11/2025
Locations: NIDDK, Phoenix, Phoenix, Arizona
NIDDK, Phoenix, Phoenix, Arizona
Conditions: Obesity, Healthy Volunteer
Study to Assess Drug Levels and Safety of Golcadomide (BMS-986369) in Healthy Participants and Participants With Different Degrees of Hepatic Impairment
Recruiting
The purpose of this study is to assess the drug levels and safety of golcadomide (BMS-986369) in adult participants with moderate and severe Hepatic Impairment (HI), and in matched healthy control participants with normal hepatic function.
The purpose of this study is to assess the drug levels and safety of golcadomide (BMS-986369) in adult participants with moderate and severe Hepatic Impairment (HI), and in matched healthy control participants with normal hepatic function. Read Less
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/01/2024
Locations: Arizona Liver Health, Chandler, Arizona +1 locations
Arizona Liver Health, Chandler, Arizona
Local Institution - 0004, Chandler, Arizona
Conditions: Hepatic Impairment, Healthy Volunteers
A Phase I Study of CDX-622
Recruiting
This is a study to determine the safety of CDX-622 in healthy participants.
This is a study to determine the safety of CDX-622 in healthy participants. Read Less
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
04/15/2025
Locations: Celerion, Inc., Tempe, Arizona
Celerion, Inc., Tempe, Arizona
Conditions: Healthy Participants
Bone Mineral Density Agreement Study Between EOSedge™ Versus Traditional DXA
Recruiting
The purpose of this research is to collect medical imaging data to allow for the comparison of bone mineral density measurements from two different types of low-dose x-ray exams, EOSedge and conventional DXA. The main question it aims to answer is:
Is there agreement between the calculated T-scores between the 2 different types of x-ray exams?
The purpose of this research is to collect medical imaging data to allow for the comparison of bone mineral density measurements from two different types of low-dose x-ray exams, EOSedge and conventional DXA. The main question it aims to answer is:
Is there agreement between the calculated T-scores between the 2 different types of x-ray exams? Read Less
Gender:
ALL
Ages:
20 years and above
Trial Updated:
02/12/2025
Locations: Honor Health, Phoenix, Arizona
Honor Health, Phoenix, Arizona
Conditions: Healthy, Indicated for EOSedge Imaging
Increasing Physical Activity Through Social Support and Stress Resilience
Recruiting
The goal of this clinical trial is to learn the effects of technology enhancements when combined with basic education, goal-setting, and self-monitoring to increase physical activity among older adults living alone, experiencing subjective cognitive decline, and currently engaging minimal physical activity (60 minutes or less of moderate to vigorous physical activity). Further, we will examine key psychosocial mechanisms believed to contribute to successful promotion of physical activity, which... Read More
The goal of this clinical trial is to learn the effects of technology enhancements when combined with basic education, goal-setting, and self-monitoring to increase physical activity among older adults living alone, experiencing subjective cognitive decline, and currently engaging minimal physical activity (60 minutes or less of moderate to vigorous physical activity). Further, we will examine key psychosocial mechanisms believed to contribute to successful promotion of physical activity, which include social support and stress resilience.
The primary questions are to determine whether
* the tech-enhanced condition lead to greater physical activity over time?
* the tech-enhanced condition lead to social support and stress resilience over time?
* social support and stress resilience mediate the relationship between the study condition and physical activity?
All participants will engage in self-monitoring of physical activity, will receive weekly text reminders of their physical activity goals for the week, and will receive basic education about the importance of physical activity, social support, and stress resilience for cognitive, physical, and psychological health. Participants in the tech-enhanced condition will also receive access to a study-specific website and virtual coaching to reinforce the information presented. Researchers will then compare the tech-enhanced condition to the basic education condition to determine the benefits of technology to deliver the intervention materials in order to increase physical activity, social support, and stress resilience.
Participants will:
* Use a Garmin wearable device to monitor their physical activity
* Be randomly assigned to a basic education condition or tech-enhanced condition
* Set achievable goals for weekly physical activity, with incremental increases to achieve 150 minutes per week by the end of the study
* Respond to surveys to monitor their social support, stress resilience, quality of life, and depression.
The sample has several risk factors for Alzheimer's disease and related dementias: low physical activity, social isolation risk via living alone, and subjective cognitive impairment. Therefore, a long-term goal includes the determination of the intervention's effectiveness at increasing physical activity, social support, and stress resilience to reduce risk for developing dementia. Read Less
Gender:
ALL
Ages:
60 years and above
Trial Updated:
07/22/2025
Locations: Arizona State University, Phoenix, Arizona
Arizona State University, Phoenix, Arizona
Conditions: Healthy, Subjective Cognitive Decline (SCD), Sedentary Behavior, Social Isolation in Older Adults
A Study of TAK-881 With and Without Ramp-Up Dosing in Healthy Adults
Recruiting
The main aim of this study is to check how well healthy adults can tolerate TAK-881 with different dosing schedules.
During the study, participants will receive one infusion of TAK-881 under the skin (subcutaneous \[SC\] infusion) on Day 1 at a lower dose level followed by participants receiving multiple infusion of higher dose levels.
Participants will be in the study for approximately 19 weeks including screening period and follow-up (End of Treatment \[EOT\]).
The main aim of this study is to check how well healthy adults can tolerate TAK-881 with different dosing schedules.
During the study, participants will receive one infusion of TAK-881 under the skin (subcutaneous \[SC\] infusion) on Day 1 at a lower dose level followed by participants receiving multiple infusion of higher dose levels.
Participants will be in the study for approximately 19 weeks including screening period and follow-up (End of Treatment \[EOT\]). Read Less
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
05/06/2025
Locations: Celerion, Tempe, Arizona
Celerion, Tempe, Arizona
Conditions: Healthy Volunteers
Medical Discoveries and Innovation in Arizona
Arizona’s commitment to innovation fuels a constant surge of transformative breakthroughs. From pioneering treatments that redefine patient care to state-of-the-art technologies that push the boundaries of possibility, this state stands at the forefront of medical innovation.
Here is a list of some of the most notable advancements of Arizona clinical research made in recent years:
- Pioneering Alzheimer’s Research – The Banner Alzheimer’s Institute, based in Phoenix, Arizona, has been at the front line of Alzheimer’s research for years. Through computational analysis and brain imaging, they have developed methods to help in the early detection of Alzheimer’s.
- Neuralink Brain Implant – Barrow Neurological Institute, a research group in Arizona is the center for Elon Musk’s company for human trials. This institute has previously contributed to standardizing brain implant surgeries, where patients can sleep through the procedure.
- Solar Power Research – Arizona State University’s research on solar energy technologies has positioned Arizona as a leader in renewable energy. ASU’s solar program is in charge of creating more than 53 MWdc.
Why Arizona Is A Great Place For Clinical Research
Arizona has a diverse population. About 53.8% of its residents are White, 31.9% are Hispanic, 4.6% are Black, 3.9% are American Indian, and 3.7% are Asian. This allows for comprehensive clinical research in Arizona to be done that represents a wide range of backgrounds, genetics, and health profiles. (7)