Paid Clinical Trials in Illinois

Candace Kastanis

Written by Candace Kastanis

Chemistry B.S. | UC Davis | Clinical Lab Technician

Clinical research Illinois is here to forge new frontiers. Thanks to a wide range of studies, researchers can improve and safeguard all discoveries that can change the world. This can be achieved by supporting three unique goals, research development, research compliance, and research infrastructure.

Illinois leads the way on collaborative journeys, where the finest minds forge new paths. IL research institutions, medical facilities, and universities provide a canvas where experts get to delve deeper, reach further, and push the boundaries of the human mind. 

Clinical Trials For Disease Areas in Illinois

Illinois sets a unique stage for groundbreaking research. Home to world-renowned research institutions like the University of Chicago, Northwestern University, and the University of Illinois Chicago (UIC), this state creates a dynamic environment with notable research strengths. 

The purpose of clinical research trials in Illinois is to identify biomarkers, obtain preliminary data, and analyze samples of different diseases. Including infectious diseases, neurological disorders, metabolic disorders, cancer, autoimmune disorders, and more.

Project WISH at Chicago, for example, has more than two decades worth of experience in carrying out basic science research and clinical research for infectious diseases. Chief of the Division of Infectious Diseases, Dr. Richard Novak is actively engaged in the study of treatment, and prevention of HIV diseases.

Here is a list of ongoing and future trials.

Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial)
NCT02201992
Recruiting
This randomized phase III trial studies how well crizotinib works in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called anaplastic lymphoma kinase (ALK). Mutations, or changes, in ALK can make it very active and important for tumor cell growth and progression. Crizotinib may stop the growth of tumor cells by blocking the ALK protein from working. Crizotinib may be an effective treatment for patients with non-sma... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/29/2024
Locations: Saint Anthony's Health, Alton, Illinois +83 locations
Conditions: ALK Gene Rearrangement, ALK Gene Translocation, ALK Positive, Stage IB Non-Small Cell Lung Carcinoma AJCC v7, Stage II Non-Small Cell Lung Cancer AJCC v7, Stage IIA Non-Small Cell Lung Carcinoma AJCC v7, Stage IIB Non-Small Cell Lung Carcinoma AJCC v7, Stage IIIA Non-Small Cell Lung Cancer AJCC v7
Register for Updates
S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer
NCT03723928
Recruiting
This randomized research trial studies how well serum tumor marker directed disease monitoring works in monitoring patients with hormone receptor positive Her2 negative breast cancer that has spread to other places in the body. Using markers to prompt when scans should be ordered may be as good as the usual approach to monitoring disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: Saint Anthony's Health, Alton, Illinois +43 locations
Conditions: Anatomic Stage IV Breast Cancer AJCC v8, Estrogen Receptor Positive, HER2/Neu Negative, Progesterone Receptor Positive, Prognostic Stage IV Breast Cancer AJCC v8, Elevated CA15-3 or CEA or CA27-29
Register for Updates
Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer
NCT03801876
Recruiting
This trial studies how well proton beam radiation therapy compared with intensity modulated photon radiotherapy works in treating patients with stage I-IVA esophageal cancer. Proton beam radiation therapy uses a beam of protons (rather than x-rays) to send radiation inside the body to the tumor without damaging much of the healthy tissue around it. Intensity modulated photon radiotherapy uses high-energy x-rays to deliver radiation directly to the tumor without damaging much of the healthy tissu... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/21/2025
Locations: Alton Memorial Hospital, Alton, Illinois +4 locations
Conditions: Clinical Stage I Esophageal Adenocarcinoma AJCC v8, Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8, Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage II Esophageal Adenocarcinoma AJCC v8, Clinical Stage II Esophageal Squamous Cell Carcinoma AJCC v8, Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8, Clinical Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage IIB Esophageal Adenocarcinoma AJCC v8, Clinical Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage III Esophageal Adenocarcinoma AJCC v8, Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8, Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8, Clinical Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8, Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8, Pathologic Stage I Esophageal Adenocarcinoma AJCC v8, Pathologic Stage I Esophageal Squamous Cell Carcinoma AJCC v8, Pathologic Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8, Pathologic Stage IA Esophageal Adenocarcinoma AJCC v8, Pathologic Stage IA Esophageal Squamous Cell Carcinoma AJCC v8, Pathologic Stage IA Gastroesophageal Junction Adenocarcinoma AJCC v8, Pathologic Stage IB Esophageal Adenocarcinoma AJCC v8, Pathologic Stage IB Esophageal Squamous Cell Carcinoma AJCC v8, Pathologic Stage IB Gastroesophageal Junction Adenocarcinoma AJCC v8, Pathologic Stage IC Esophageal Adenocarcinoma AJCC v8, Pathologic Stage IC Gastroesophageal Junction Adenocarcinoma AJCC v8, Pathologic Stage II Esophageal Adenocarcinoma AJCC v8, Pathologic Stage II Esophageal Squamous Cell Carcinoma AJCC v8, Pathologic Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8, Pathologic Stage IIA Esophageal Adenocarcinoma AJCC v8, Pathologic Stage IIA Esophageal Squamous Cell Carcinoma AJCC v8, Pathologic Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8, Pathologic Stage IIB Esophageal Adenocarcinoma AJCC v8, Pathologic Stage IIB Esophageal Squamous Cell Carcinoma AJCC v8, Pathologic Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8, Pathologic Stage III Esophageal Adenocarcinoma AJCC v8, Pathologic Stage III Esophageal Squamous Cell Carcinoma AJCC v8, Pathologic Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8, Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8, Pathologic Stage IIIA Esophageal Squamous Cell Carcinoma AJCC v8, Pathologic Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8, Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8, Pathologic Stage IIIB Esophageal Squamous Cell Carcinoma AJCC v8, Pathologic Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8, Pathologic Stage IVA Esophageal Adenocarcinoma AJCC v8, Pathologic Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8, Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage I Esophageal Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage I Esophageal Squamous Cell Carcinoma AJCC v8, Postneoadjuvant Therapy Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage II Esophageal Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage II Esophageal Squamous Cell Carcinoma AJCC v8, Postneoadjuvant Therapy Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage III Esophageal Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage III Esophageal Squamous Cell Carcinoma AJCC v8, Postneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage IIIA Esophageal Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage IIIA Esophageal Squamous Cell Carcinoma AJCC v8, Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage IIIB Esophageal Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage IIIB Esophageal Squamous Cell Carcinoma AJCC v8, Postneoadjuvant Therapy Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage IVA Esophageal Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8, Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8, Thoracic Esophagus Squamous Cell Carcinoma
Register for Updates
Dietary Supplementation on Gastrointestinal Barrier Function
NCT06262880
Recruiting
The purpose of the current study is to examine the effects of a dietary supplement containing plant derived phenolics at two different dose levels on parameters of gastrointestinal (GI) health in otherwise generally healthy adults with risk factors (high BMI and waist circumference) for increased GI permeability. The primary hypothesis is that supplementation with plant derived phenolics will improve gut health compared to placebo.
Gender:
ALL
Ages:
Between 30 years and 69 years
Trial Updated:
03/06/2024
Locations: Biofortis, Addison, Illinois
Conditions: Intestinal Permeability
Register for Updates
Dietary Supplementation on Body Fat Composition
NCT06296251
Recruiting
The purpose of the current study is to examine the effects of a dietary supplement containing plant derived phenolics at two different dose levels in otherwise generally healthy adults with risk factors (high BMI at dyslipidemia and/or pre-diabetes) for body fat composition. The primary hypothesis is that supplementation with plant derived phenolics will decrease body fat composition compared to placebo.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/13/2024
Locations: Biofortis Research, Addison, Illinois
Conditions: Dyslipidemias, Pre-diabetes
Register for Updates
Dietary Supplementation on Fat Oxidation
NCT06548048
Recruiting
The purpose of this pilot study is to evaluate the effects of 4 weeks of daily consumption of encapsulated N-trans-caffeoyl tyramine (NCT) and N-trans-feruloyl tyramine (NFT) at a dose of 120 mg/d on measures of fat oxidation in women with overweight or obesity. The hypothesis is that fat oxidation at rest (measured via indirect calorimetry) and over a 24 h period (measured via d31-palmitic acid stable isotope tracer) will be higher in the group receiving the active study product compared to the... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
08/08/2024
Locations: Biofortis, Addison, Illinois
Conditions: Overweight, Obesity
Register for Updates
A Clinical Trial to Assess Cognitive Effects of Cognitive Nutritional Supplement in General Population
NCT06837246
Recruiting
This is a double-blind, randomized, 12-week parallel study that aims to determine the effects of a cognitive nutritional supplement for 12 weeks on cognition parameters specific to attention/focus related domains, compared to a placebo control, in a general population of adult men and women in the United States.
Gender:
ALL
Ages:
Between 25 years and 65 years
Trial Updated:
04/10/2025
Locations: Biofortis Innovation Services, Addison, Illinois
Conditions: Cognition, Concentration, Attention, Focus
Register for Updates
Acute Appetite Hormone Response of Proprietary Beverages
NCT06966570
Recruiting
The primary objective of this study is to evaluate post-meal appetite hormones and appetite ratings, assessed using visual analog scale (VAS) questionnaires, in response to proprietary beverages in generally healthy adults.
Gender:
ALL
Ages:
Between 20 years and 50 years
Trial Updated:
05/07/2025
Locations: Biofortis Clinical Research, Addison, Illinois
Conditions: Healthy
Register for Updates
Effects of Effera Human Lactoferrin at One Dose Compared to Placebo on Gut Permeability
NCT07035964
Recruiting
The purpose of this study is to evaluate the impact of 28-day supplementation with effera human lactoferrin, compared to a placebo control product on indicators of gut barrier health in males and females
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
06/16/2025
Locations: Biofortis Inc, Addison, Illinois
Conditions: Gut Permeability, Gut Health
Register for Updates
Postprandial Response to Fruit Juice
NCT07103083
Recruiting
The goal of this clinical trial is to determine postprandial responses to fruit juices.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
07/28/2025
Locations: Biofortis Innovation Services, Addison, Illinois
Conditions: Blood Glucose, Blood Insulin
Register for Updates

Around 2.2 million people took part in clinical trials in 2013. The same year, a study from the Center for Information and Study on Clinical Research Participation (CISCRP) revealed that 95% of those who took part in clinical trials would be open to joining another. Additionally, 91% rated their experience as “Good” or “Excellent”. 

IL paid clinical trials can lessen the financial burden on patients in need of medical treatment. Compensation for paid clinical trials in Illinois will vary. It can come in the form of reimbursement, bonus, incentive, or payment. 

Click here for Illinois clinical trials in Chicago.

Clinical Trials For Health Volunteers in Illinois

Volunteers for clinical trials in Illinois play an active role in their own healthcare. This is a very important and personal decision.

Volunteers contribute to the advancement of research and medical knowledge. Different ethnic or racial groups are highly encouraged to participate, as minorities tend to be under-represented in clinical trials.

Here is a list of trials you can volunteer.

The Gut and Skin Microbiome in Vitiligo Disease Progression
NCT03577327
Recruiting
Investigators plan to perform a pilot study that aims to characterize the microbiome of human vitiligo patients with both active and stable disease and compare this to the microbiome of age and sex matched controls. The investigators aim to answer the question whether the gut and skin microbiome of patients with vitiligo differs from the general population.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
05/02/2025
Locations: Northwestern University, Chicago, Illinois
Conditions: Vitiligo, Healthy
Register for Updates
Anti-mullerian Hormone Levels in Healthy Females
NCT04537390
Recruiting
The purpose of this study is to have a better understanding of the normal blood levels of AMH in females from 0-18 years of age and how the blood AMH levels correspond to a female's reproductive development.
Gender:
FEMALE
Ages:
18 years and below
Trial Updated:
11/14/2024
Locations: Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Healthy
Register for Updates
Testing the Contribution of Orbitofrontal Cortex Networks to Decision-making
NCT05111223
Recruiting
This research study examines the contribution of orbitofrontal cortex (OFC) networks to decision-making.
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
08/16/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Healthy
Register for Updates
Deliver-EE: Evaluating Effects of Meal Delivery
NCT05357261
Recruiting
This study will randomly assign 2,300 older adults on waiting lists at fourteen Meals on Wheels programs in Florida, Illinois, Maryland, Tennessee, Texas, North Carolina, South Carolina, and California into two groups who will receive: (a) daily delivery of meals, five days a week or (b) a shipment of 10 frozen meals, every two weeks. Researchers will examine participants' Medicare claims to understand if differences in healthcare utilization occur between the two groups within six months after... Read More
Gender:
ALL
Ages:
66 years and above
Trial Updated:
04/21/2025
Locations: Meals on Wheels Northeastern Illinois, Evanston, Illinois
Conditions: Healthy
Register for Updates
Hyperpolarized 129Xe MRI Lung Health Cohort
NCT05766384
Recruiting
A subset of young adults participating in the American Lung Association (ALA) Lung Health Cohort (LHC) will be imaged using Hyperpolarized 129Xe MRI to assess lung structure and function. Images will be used to improve the understanding of lung health and early lung abnormalities that may lead to chronic lung disease.
Gender:
ALL
Ages:
Between 25 years and 35 years
Trial Updated:
04/01/2025
Locations: University of Illinois-Chicago, Chicago, Illinois
Conditions: Healthy
Register for Updates
Effects of Vibration on Motor Function of Survivors of Chronic Stroke
NCT06663501
Recruiting
The aim of this study is to evaluate how vibration of the tendons enhances arm and hand training in survivors of chronic stroke. The investigators hypothesize that wrist/elbow robotic training, combined with body awareness training will improve arm and hand function in individuals with chronic stroke.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
12/03/2024
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Stroke, Healthy
Register for Updates
EvaluatIng Normal Values for TraditionaL AnorectaL FUnction ParaMeters with AIr Charged and Solid State HRAM CatheTErs ("ILLUMINATE" Study)
NCT06805240
Recruiting
The research study will be conducted to obtain baseline, or "normative" information to compare an air charged HRAM catheter to traditional solid catheter measures using the IAPWG standardized testing protocol and London classification.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/18/2025
Locations: Southwest Gastroenterology, New Lenox, Illinois
Conditions: Healthy
Register for Updates
A Clinical Study of MK-1084 in Participants With Renal Impairment (MK-1084-010)
NCT06814119
Recruiting
The goal of this study is to learn what happens to MK-1084 levels in a person's body over time. Researchers will measure what happens to MK-1084 levels in the body when it is given to people with moderate or severe renal impairment (RI) (meaning the kidneys do not work properly) as compared to people who are in good health. Researchers also want to learn about the safety of MK-1084 when it is given to people with RI and if people with RI can tolerate it.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/05/2025
Locations: Research by Design ( Site 0001), Chicago, Illinois
Conditions: Healthy, Renal Impairment
Register for Updates
Acute Appetite Hormone Response of Proprietary Beverages
NCT06966570
Recruiting
The primary objective of this study is to evaluate post-meal appetite hormones and appetite ratings, assessed using visual analog scale (VAS) questionnaires, in response to proprietary beverages in generally healthy adults.
Gender:
ALL
Ages:
Between 20 years and 50 years
Trial Updated:
05/07/2025
Locations: Biofortis Clinical Research, Addison, Illinois
Conditions: Healthy
Register for Updates
WIM Exosuit Wearable Soft Robot for Enhancing Walking Activity
NCT07061691
Recruiting
This study is to develop, test, and optimize a soft hip wearable robot for individuals who have experience a stroke.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
07/08/2025
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Stroke, Healthy
Register for Updates

Medical Discoveries and Innovation in Illinois

Illinois isn’t just a state; it’s a living testament of medical marvels. From groundbreaking treatments to cutting-edge technologies, Illinois clinical research teams have made it their life’s goal to provide superior patient-centered care.

One of the most notable discoveries in IL are the organ transplant breakthroughs. In 1999, UChicago Medicine completed the world’s first successful heart-liver-kidney transplant. 

In 2018, experts performed the first ever back-to-back triple-organ transplants, replacing failing livers, hearts, and kidneys for two patients. In 2020, they made history again with one of the country’s earliest heart transplants for a patient whose heart was damaged by COVID-19.

Why Illinois Is A Great Place For Clinical Research 

Illinois has a diverse population, making it a great place for comprehensive data research. The majority (60%) are white, 18% are Hispanic, 14.1% are Black, 5.9% are Asian, and 1.8% are multiracial. 

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