Paid Clinical Trials in Boston

Candace Kastanis

Written by Candace Kastanis

Chemistry B.S. | UC Davis | Clinical Lab Technician

Updated & Fact Checked 7/30/26

Healthy Participant Trials in Boston

Boston has one of the densest concentrations of clinical research anywhere in the world. As of July 2026, 2,651 studies are actively recruiting in the city, according to ClinicalTrials.gov, spread across a cluster of teaching hospitals within a few miles of each other.

If you are seeking paid clinical trials for healthy volunteers nearby, you can probably find one within walking distance of wherever you live. Of course, it will depend on where you live, but there are over 900 Clinical Research Organization (CRO) opportunities in Boston.

Each CRO will have trials that include multiple participants–in most cases. So you need to know how many people in the USA need to be involved in such experimentation to advance medical science year over year, and you need to know the population of Boston. Experts say .005%, or 1 in 200, need to be involved in such trials continuously to advance the science.

There are approximately 687,257 people in Boston, but the Boston metro area includes nearly 5,000,000 people. You’ve got to factor that in when you’re looking for CRO opportunities nearby. When you crunch the numbers, you can expect each CRO to have clinical trials featuring between 3 and 27 individual opportunities per CRO in Boston, depending on if you expand your search beyond Boston proper into the metro area or not. Here we will explore some demographic data of Boston proper to help you get an idea of what to expect within the city limits.

Quick Facts: Paid Clinical Trials in Boston

  • Actively recruiting studies (July 2026): 2,651 (ClinicalTrials.gov)
  • Typical compensation: $50–$100 per completed outpatient visit; residential Phase 1 studies pay more (see highest paid clinical trials)
  • Cost to participate: $0 — study care and visits are covered by the sponsor
  • Worth knowing: the Longwood Medical Area packs several major research hospitals into walking distance, all on the Green Line
  • Statewide options: paid clinical trials in Massachusetts

Where Boston trials actually run

We sampled recruiting Boston studies on ClinicalTrials.gov in July 2026. The sites running the most trials:

Research siteTrials sampled
Massachusetts General Hospital121
Dana-Farber Cancer Institute108
Brigham and Women’s Hospital60
Beth Israel Deaconess Medical Center53
Boston Children’s Hospital38

The Longwood Medical Area alone holds Dana-Farber, Brigham and Women’s, Boston Children’s, and Beth Israel Deaconess, with Mass General just across the river. Almost every specialty is represented, and many studies are first-in-human trials that do not run anywhere else.

Demographic Data Helps Show Trial Availability in Boston

A big factor that will influence what paid clinical trials nearby for healthy volunteers are available will be localized demographic info. In Boston proper, 52.11% of the population is white, 24.20% are Black or of African descent, 9.82% are Asian, and 7.25% are comprised of 2 or more races. The average age of locals is 32, with 52.05% being female, and 47.95% being male.

We have compiled the following list of paid clinical trials for healthy volunteers, click the Search All button at the bottom to find more:

Follow-up Visit of High Risk Infants
Recruiting
The NICHD Neonatal Research Network's Follow-Up study is a multi-center cohort in which surviving extremely low birth-weight infants born in participating network centers receive neurodevelopmental, neurosensory and functional assessments at 22-26 months corrected age (Infants born prior to July 1, 2012 were seen at 18-22 months corrected age). Data regarding pregnancy and neonatal outcome are collected prospectively. The goal is to identify potential maternal and neonatal risk factors that may... Read More
Gender:
ALL
Ages:
Between 18 months and 26 months
Trial Updated:
02/11/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
Consent for Use of Stored Patient Specimens for Future Testing
Recruiting
The purpose of this study is to obtain informed consent to use stored human biological materials (HBM) (e.g., blood and other tissues) for future studies that may include genetic testing.
Gender:
ALL
Ages:
All
Trial Updated:
09/20/2024
Locations: Univ of Southern California / LA County USC Med Ctr, Los Angeles, California +3 locations
Conditions: HIV Infections
Human Epilepsy Genetics--Neuronal Migration Disorders Study
Recruiting
The purpose of this study is to identify genes responsible for epilepsy, brain malformations and disorders of human cognition.
Gender:
ALL
Ages:
All
Trial Updated:
09/20/2023
Locations: Boston Children's Hospital, Walsh Laboratory, Boston, Massachusetts
Conditions: Epilepsy, Brain Malformation, Neuronal Migration Disorder, Cognition Disorder
Generic Database of Very Low Birth Weight Infants
Recruiting
The Generic Database (GDB) is a registry of very low birth weight infants born alive in NICHD Neonatal Research Network (NRN) centers. The GDB collects observational baseline data on both mothers and infants, and the therapies used and outcomes of the infants. The information collected is not specific to a disease or treatment (i.e., it is "generic"). Data are analyzed to find associations and trends between baseline information, treatments, and infant outcome, and to develop future NRN trials.
Gender:
ALL
Ages:
14 days and below
Trial Updated:
02/11/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
Healey ALS Platform Trial: IC14 Arm
Recruiting
The HEALEY ALS Platform Trial is a perpetual multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of ALS
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
05/14/2020
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Amyotrophic Lateral Sclerosis
Testing Obeticholic Acid (OCA) for Familial Adenomatous Polyposis (FAP)
Recruiting
This is a trial that intends to evaluate the effect of treatment with the drug obeticholic acid in the treatment of the Familial Adenomatous Polyposis condition.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/18/2021
Locations: Mayo Clinic Arizona, Phoenix, Arizona
Conditions: Familial Adenomatous Polyposis
Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL
Recruiting
The purpose of this study is to evaluate the efficacy and safety of acalabrutinib in combination with venetoclax and acalabrutinib in combination with venetoclax with and without obinutuzumab compared to chemoimmunotherapy in subjects with previously untreated CLL.
Gender:
All
Ages:
Between 18 years and 130 years
Trial Updated:
01/14/2022
Locations: Research Site, Fountain Valley, California +1 locations
Conditions: Chronic Lymphocytic Leukemia
Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer
Recruiting
This is a Phase 3, open-label, randomized, clinical trial evaluating the efficacy and safety of gedatolisib plus fulvestrant with or without palbociclib for the treatment of patients with locally advanced or metastatic HR+/HER2- breast cancer following progression on or after CDK4/6 and aromatase inhibitor therapy. Condition or disease: Breast Cancer Intervention/treatment: Drug: Gedatolisib Drug: Palbociclib Drug: Fulvestrant Drug: Alpelisib Phase 3
Gender:
All
Ages:
18 years and above
Trial Updated:
08/02/2022
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Breast Cancer
A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
Recruiting
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: GSK Investigational Site, Goodyear, Arizona
Conditions: Neoplasms
A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide Maintenance Therapy Versus Lenalidomide Maintenance Therapy Alone in Adult Participants With Newly Diagnosed Multiple Myeloma Who Have Suboptimal Response After Autologous Stem Cell Transplantation
Recruiting
The purpose of this study is to compare the efficacy, safety, and tolerability of ide-cel with lenalidomide (LEN) maintenance to that of LEN maintenance alone in adult participants with Newly Diagnosed Multiple Myeloma (NDMM) who have achieved a suboptimal response post autologous stem cell transplantation (ASCT).
Gender:
All
Ages:
18 years and above
Trial Updated:
05/01/2024
Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +1 locations
Conditions: Multiple Myeloma

Interpreting Boston Diversity Data to Find Paid Trials

What this indicates is that paid clinical trials for healthy volunteers in Boston will be most numerous for white females in their early 30s, followed by males in the same category, those of African descent, and Asians. But, and this is always worth pointing out, there will be opportunities for all walks of life in Boston and the surrounding metro area; the diverse population predicates demand. You may just have to do a little more searching to find them. That said, it shouldn’t be hard. CROs are in abundance throughout Boston, and they always need healthy volunteers.


Boston CROs With Opportunities for Healthy Participants

To help you figure out which healthy volunteer paid clinical trials define Boston, here are three notable CROs to choose from the north, south, and east of the city:


Notable Medical Breakthroughs in Boston

Boston has a history for multiple reasons, not least of which their contributions to medical science in the last several hundred years. You can be a part of that, and receive remuneration to boot. Here are some well-known breakthroughs in the area:


Across the river, Cambridge runs its own research programs and lists separately from Boston:

  • Cambridge — about 207 recruiting studies: MIT, the Broad Institute, and the biotech cluster around Kendall Square

Cambridge is a short ride on the Red Line from downtown Boston, and early-phase industry studies are common there.

Boston Paid Clinical Trial FAQs

  • How much do paid clinical trials pay here?

    Most outpatient studies pay $50–$100 per completed visit, plus travel reimbursement. Residential Phase 1 studies pay considerably more. The exact amount appears in the consent form before you enroll.

  • Where in Boston are most trials located?

    The Longwood Medical Area in the Fenway neighborhood holds Dana-Farber, Brigham and Women’s, Boston Children’s, and Beth Israel Deaconess. Massachusetts General is in the West End near Charles/MGH station. Both areas are reachable by the T.

  • Do I have to be a patient at these hospitals to join a study?

    No. Boston hospitals recruit widely, including healthy volunteers for Phase 1 and imaging studies. Because the hospitals compete for participants, it is worth contacting several — eligibility criteria differ between protocols even for the same condition.

Boston CRO Trial Opportunities: Available if You Want Them

If you need to supplement your income, and you want to be a part of history, you’ve got literally thousands of opportunities in Boston and the Greater Boston Area. Basically, if you are willing to search out CROs, you have an option to make some money. Being a part of history in a meaningful way is easier today than perhaps it has ever been.