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Clinical research in Michigan holds immense value in improving patient care. Through dedication, innovation, collaboration, and creativity, scientists create novel opportunities that can accommodate patients in the years to come.
Even now, the state of Michigan has a sizable history of successful clinical trials, innovations, and discoveries that have improved the quality of life and treatment outcomes for diverse patient groups.
Clinical Trials For Disease Areas in Michigan
Michigan is a hub for cancer research. Clinical trials in the area target different types of cancers such as breast, lung, prostate, and leukemia. State experts are also studying treatments for neurological conditions. Such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis.
Clinical research trials in Michigan assess other diseases. Mainly infectious, respiratory, rare, and autoimmune disorders. Options such as these help diversify the pool of innovations and discoveries for creating personalized treatment plans.
Take a look at the list below to find future or active trials near you.
Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee
Recruiting
This clinical trial is being done to better understand how daily treatment with tetrahydrocannabinol (THC), cannabidiol (CBD), or the combination of CBD plus THC affects knee osteoarthritis pain and other related symptoms.
Consented participants will have a screening period and visit (up to 30 days to treatment start). If participants pass the screening phase, they will be randomly assigned to take one of the investigational study drugs. For this study, participants will not know when or if the... Read More
This clinical trial is being done to better understand how daily treatment with tetrahydrocannabinol (THC), cannabidiol (CBD), or the combination of CBD plus THC affects knee osteoarthritis pain and other related symptoms.
Consented participants will have a screening period and visit (up to 30 days to treatment start). If participants pass the screening phase, they will be randomly assigned to take one of the investigational study drugs. For this study, participants will not know when or if they are taking CBD, THC, THC plus CBD, and when or if taking placebo.
Clinical pain will be assessed at multiple times throughout the study, and eligibility will be re-assessed at two weeks into the treatment period. It is possible that subjects will not be able to participate in the study after two weeks of treatment.The treatment period will take approximately 16 weeks and then a follow-up period for approximately 2 weeks. In addition to treatment, participants will have clinical assessments, blood draws, questionnaires, daily pain diaries, sensory testing, as well as have functional connectivity magnetic resonance imaging (fcMRI).
This studies primary hypothesis is that CBD alone will exert a peripheral anti-inflammatory effect shown through decreases in circulating levels of Interleukin-6 (IL-6), THC alone will modify central nervous system (CNS) pain processing via decreased insula to Default Mode Network (DMN) connectivity, and CBD plus THC will do both. Read Less
Gender:
All
Ages:
Between 21 years and 75 years
Trial Updated:
11/02/2020
Locations: University of Michigan, Ann Arbor, Michigan
University of Michigan, Ann Arbor, Michigan
Conditions: Osteoarthritis, Knee
An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis
Recruiting
The present study D5272C00001 (Legacy # 3151-201-008) seeks to evaluate the efficacy and safety of brazikumab versus placebo in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy.
The present study D5272C00001 (Legacy # 3151-201-008) seeks to evaluate the efficacy and safety of brazikumab versus placebo in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy. Read Less
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/19/2021
Locations: Research Site, Wyoming, Michigan
Research Site, Wyoming, Michigan
Conditions: Ulcerative Colitis
Testing Obeticholic Acid (OCA) for Familial Adenomatous Polyposis (FAP)
Recruiting
This is a trial that intends to evaluate the effect of treatment with the drug obeticholic acid in the treatment of the Familial Adenomatous Polyposis condition.
This is a trial that intends to evaluate the effect of treatment with the drug obeticholic acid in the treatment of the Familial Adenomatous Polyposis condition. Read Less
Gender:
All
Ages:
18 years and above
Trial Updated:
11/18/2021
Locations: University of Michigan, Ann Arbor, Michigan
University of Michigan, Ann Arbor, Michigan
Conditions: Familial Adenomatous Polyposis
Study to Evaluate The Safety and Efficacy of Balovaptan in Patients With Acute Ischemic Stroke at High Risk of Developing Malignant Brain Edema
Recruiting
This study is designed to evaluate the safety, efficacy, and pharmacokinetics of balovaptan compared with placebo in participants with acute ischemic stroke (AIS) at risk of developing malignant cerebral edema (MCE)
This study is designed to evaluate the safety, efficacy, and pharmacokinetics of balovaptan compared with placebo in participants with acute ischemic stroke (AIS) at risk of developing malignant cerebral edema (MCE) Read Less
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
04/04/2022
Locations: McLaren Regional Medical Center, Flint, Michigan
McLaren Regional Medical Center, Flint, Michigan
Conditions: Acute Ischemic Stroke
Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer
Recruiting
This is a Phase 3, open-label, randomized, clinical trial evaluating the efficacy and safety of gedatolisib plus fulvestrant with or without palbociclib for the treatment of patients with locally advanced or metastatic HR+/HER2- breast cancer following progression on or after CDK4/6 and aromatase inhibitor therapy.
Condition or disease:
Breast Cancer
Intervention/treatment:
Drug: Gedatolisib
Drug: Palbociclib
Drug: Fulvestrant
Drug: Alpelisib
Phase 3
This is a Phase 3, open-label, randomized, clinical trial evaluating the efficacy and safety of gedatolisib plus fulvestrant with or without palbociclib for the treatment of patients with locally advanced or metastatic HR+/HER2- breast cancer following progression on or after CDK4/6 and aromatase inhibitor therapy.
Condition or disease:
Breast Cancer
Intervention/treatment:
Drug: Gedatolisib
Drug: Palbociclib
Drug: Fulvestrant
Drug: Alpelisib
Phase 3 Read Less
Gender:
All
Ages:
18 years and above
Trial Updated:
08/02/2022
Locations: Henry Ford Hospital, Detroit, Michigan
Henry Ford Hospital, Detroit, Michigan
Conditions: Breast Cancer
Next-Generation Endometriosis Diagnostics Through Comprehensive Multi-Dimensional Analysis
Recruiting
This study is a multicentric, observational, case-control, non-profit with additional procedures. It aims to deepen the understanding of the chronic gynecological conditions of endometriosis and adenomyosis, which significantly impact women's reproductive health. Its purpose is to improve early diagnosis and personalized treatment of these conditions using a multi-omic approach, that integrates genetic, epigenetic, imaging, and endometrial receptivity data. The goal is also to refine image-based... Read More
This study is a multicentric, observational, case-control, non-profit with additional procedures. It aims to deepen the understanding of the chronic gynecological conditions of endometriosis and adenomyosis, which significantly impact women's reproductive health. Its purpose is to improve early diagnosis and personalized treatment of these conditions using a multi-omic approach, that integrates genetic, epigenetic, imaging, and endometrial receptivity data. The goal is also to refine image-based predictions through recent advancements in artificial intelligence and to study uterine extracellular vesicles to assess fertility non-invasively.
The study targets patients with endometriosis and/or adenomyosis and involves women seeking fertility treatments at assisted reproduction centers, who will serve as a control population.
The study comprises both prospective and retrospective components. The prospective recruitment involves the collection of blood and uterine fluid samples, while the retrospective element utilizes pre-existing biobank samples for comprehensive genetic and epigenetic analysis. Read Less
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
01/21/2025
Locations: IRCCS San Raffaele Hospital, Milan, Michigan
IRCCS San Raffaele Hospital, Milan, Michigan
Conditions: Endometriosis, Adenomyosis
Italian Adaptation and Validation of Functional and Behavioural Scales for Subjective Cognitive Decline, Mild Cognitive Impairment and Mild Dementia.
Recruiting
The first aim of the observational study is the translation, cross-cultural adaptation and validation of functional and behavioral scales used in the diagnosis of neurodegenerative diseases, for which a formal version in Italian is not available at present. In particular, the study includes the following functional and behavioral scales: the Katz's index (Basic Activities of Daily Living, BADL), the Lawton and Brody's scale (Instrumental Activities of Daily Living, IADL), the Everyday Cognition... Read More
The first aim of the observational study is the translation, cross-cultural adaptation and validation of functional and behavioral scales used in the diagnosis of neurodegenerative diseases, for which a formal version in Italian is not available at present. In particular, the study includes the following functional and behavioral scales: the Katz's index (Basic Activities of Daily Living, BADL), the Lawton and Brody's scale (Instrumental Activities of Daily Living, IADL), the Everyday Cognition questionnaire (E-Cog), the Neuropsychiatric Inventory Questionnaire (NPI-Q) for assessing the Behavioral and Psychological Symptoms of Dementia. Furthermore, a modified Italian version of the Functional Activities Questionnaire (FAQ), which integrates and updates the content of the original items (e.g., addressing the use of technologies, M-FAQ) will be used in the validation study.
The second aim is to evaluate the psychometric properties of the M-FAQ, the ECog, and the NPI-Q in terms of reliability and validity.
The third aim is to apply a Receiver Operating Characteristic (ROC) curve analysis to identify cut-offs of IADL, M-FAQ and ECOG to discriminate between different clinical groups (i.e., neurologically unimpaired elderly; Subjective Cognitive Decline, SCD; Mild Cognitive Impairment, MCI; mild Alzheimer's Disease, AD).
Neurologically unimpaired elderly participants (over 60 years old) and participants with SCD, MCI, mild AD, and their caregivers/informants will undergo: i) administration of the translated versions of the scales; ii) administration of a Cognitive Reserve questionnaire. For SCD, MCI and AD participants, data from the clinical neuropsychological evaluation will also be collected, while paper-and-pencil psychometric tests to assess global cognitive functioning (Mini Mental State Examination) and logical-abstract reasoning (Raven's Colored Matrices) will be administered to the neurologically unimpaired participants. Read Less
Gender:
ALL
Ages:
60 years and above
Trial Updated:
02/11/2025
Locations: Casa di Cura Igea, Milano, Michigan
Casa di Cura Igea, Milano, Michigan
Conditions: Neurologically Unimpaired Elderly Participants, Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), Major Neurocognitive Disorder
Effects of Vaping on Post-operative Recurrence of Crohn's Disease
Recruiting
Tobacco smoke is a well-established risk factor for post-operative recurrence of Crohn's disease. Over the last few decades electronic cigarettes have gained popularity as an alternative to traditional tobacco, however, their effects on Crohn's disease are unknown.
Tobacco smoke negatively impacts most outcomes of Crohn's disease including, but not limited to, response to therapy and risk of hospitalization. Smoke is particularly relevant in the post-operative setting, as it increases the chanc... Read More
Tobacco smoke is a well-established risk factor for post-operative recurrence of Crohn's disease. Over the last few decades electronic cigarettes have gained popularity as an alternative to traditional tobacco, however, their effects on Crohn's disease are unknown.
Tobacco smoke negatively impacts most outcomes of Crohn's disease including, but not limited to, response to therapy and risk of hospitalization. Smoke is particularly relevant in the post-operative setting, as it increases the chance of disease recurrence after surgical resection, and therefore prophylactic treatment with biologics is recommended in Crohn's patients who smoke.
At present, there are no studies evaluating the impact of e-cigarette smoke on post-operative recurrence and therefore informing physicians on the appropriateness of prophylactic treatment in this subset of patients. This study aims to assess the impact of vaping (or smoking of electronic cigarettes) on Crohn's disease endoscopic recurrence after resection as compared to non-smoke and smoke of traditional tobacco cigarettes. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/11/2024
Locations: IRCCS San Raffaele, Milano, Michigan
IRCCS San Raffaele, Milano, Michigan
Conditions: The Impact of Vaping on Crohn's Disease Endoscopic Recurrence After Resection
Study of a 4-Dose Regimen of a 21-valent Pneumococcal Conjugate Vaccine in Healthy Infants From Approximately 2 Months of Age
Recruiting
This study is a Phase 3, randomized, modified double-blind study which aims to measure whether PCV21 vaccine (investigational pneumococcal conjugate vaccine) is safe and can help the body to develop germ-fighting agents called "antibodies" (immunogenicity) compared with 20-valent pneumococcal vaccine (Prevnar 20, licensed pneumococcal conjugate vaccine) when they are administered with routine pediatric vaccines in infants aged from approximately 2 months (42 to 89 days).
The study duration per... Read More
This study is a Phase 3, randomized, modified double-blind study which aims to measure whether PCV21 vaccine (investigational pneumococcal conjugate vaccine) is safe and can help the body to develop germ-fighting agents called "antibodies" (immunogenicity) compared with 20-valent pneumococcal vaccine (Prevnar 20, licensed pneumococcal conjugate vaccine) when they are administered with routine pediatric vaccines in infants aged from approximately 2 months (42 to 89 days).
The study duration per participant will be up to approximately 19 months. The study vaccines (either PCV21 or 20-valent pneumococcal vaccines) will be administered at approximately 2, 4, 6 and 12 to 15 months of age. Routine pediatric vaccines will be given at the same timepoints.
There will be 6 study visits:
-Visit (V)01, V02 separated from V01 by 60 days, V03 separated from V02 by 60 days, V04 separated from V03 by 30 days, V05 at 12 months of age until 15 months of age, V06 separated from V05 by 30 days. Read Less
Gender:
ALL
Ages:
Between 42 days and 89 days
Trial Updated:
08/20/2025
Locations: Cardiotest Prywatna Klinika Kardiologii- Site Number : 8400207, Tychy, Michigan
Cardiotest Prywatna Klinika Kardiologii- Site Number : 8400207, Tychy, Michigan
Conditions: Pneumococcal Immunization
Liver Transplantation for Unresectable Perihilar Cholangiocarcinoma
Recruiting
This is multicentric, single-arm, observational, investigator-drive study investigating the efficacy of liver transplantation after successful downstaging/disease control of unresectable perihilar cholangiocarcinoma using chemotherapy +/- immunotherapy and stereotactic body radiation therapy (SBRT).
This is multicentric, single-arm, observational, investigator-drive study investigating the efficacy of liver transplantation after successful downstaging/disease control of unresectable perihilar cholangiocarcinoma using chemotherapy +/- immunotherapy and stereotactic body radiation therapy (SBRT). Read Less
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/15/2025
Locations: Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Michigan
Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Michigan
Conditions: Perihilar Cholangiocarcinoma, Klatskin Tumor
Paid Clinical Trials in Michigan
There are lots of benefits to taking part in paid clinical trials in Michigan. By volunteering, you help develop medicines and treatments for the future. You also get paid for your time.
The compensation for MI paid clinical trials varies based on the duration, phase of the trial, and the risks that come with it. This compensation can come in the form of financial gain or other benefits.
Clinical Trials For Health Volunteers in Michigan
Volunteers from different backgrounds and races come together to provide comprehensive data to better understand a wide range of health issues. Both healthy and sick volunteers are welcome to help scientists collect valuable feedback.
Back in 2018, a $45 million clinical trial was used to assess and study sleep apnea treatment in stroke survivors. Research teams in Michigan provided crucial data that can help the brain recover after a stroke.
If you want to volunteer for clinical trials, check the list below.
Integrated Cancer Repository for Cancer Research
Recruiting
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct characteristic of the iCaRe2 is its geographical coverage, with a significant percentage of small and rural hospitals and cancer centers. The iCaRe2 advances comprehensive studies of risk factors of cancer... Read More
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct characteristic of the iCaRe2 is its geographical coverage, with a significant percentage of small and rural hospitals and cancer centers. The iCaRe2 advances comprehensive studies of risk factors of cancer development and progression and enables the design of novel strategies for prevention, screening, early detection and personalized treatment of cancer. Centers with expertise in cancer epidemiology, genetics, biology, early detection, and patient care can collaborate by using the iCaRe2 as a platform for cohort and population studies. Read Less
Gender:
ALL
Ages:
Between 19 years and 110 years
Trial Updated:
06/04/2025
Locations: University of Michigan Health System, Ann Arbor, Michigan
University of Michigan Health System, Ann Arbor, Michigan
Conditions: Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer, Thymus Cancer, Colon Cancer, Rectal Cancer, Anal Cancer, Bile Duct Cancer, Duodenal Cancer, Gallbladder Cancer, Gastric Cancer, Liver Cancer, Small Intestine Cancer, Peritoneal Surface Malignancies, Familial Adenomatous Polyposis, Lynch Syndrome, Bladder Cancer, Kidney Cancer, Penile Cancer, Prostate Cancer, Testicular Cancer, Ureter Cancer, Urethral Cancer, Hypopharyngeal Cancer, Laryngeal Cancer, Lip Cancer, Oral Cavity Cancer, Nasopharyngeal Cancer, Oropharyngeal Cancer, Paranasal Sinus Cancer, Nasal Cavity Cancer, Salivary Gland Cancer, Skin Cancer, Mesothelioma, Breast Cancer, Leukemia, Melanoma, Sarcoma, Unknown Primary Tumor, Multiple Myeloma, Ovarian Cancer, Endometrial Cancer, Vaginal Cancer, Neuroendocrine Tumors, Plasma Cell Dyscrasia, Healthy Control, Gastrointestinal Stromal Tumors, Central Nervous System Tumor, Central Nervous System Cancer
Identification of Biomarkers for Stress Vulnerability and Resilience
Recruiting
The purpose of this research study is to understand the biological mechanisms of stress vulnerability (being susceptible to stress) and stress resilience (being able to recover readily from stress), obtain biomarkers (a biological indicator) for stress resilience and to devise strategies for prevention and treatment of stress-related disorders.
The purpose of this research study is to understand the biological mechanisms of stress vulnerability (being susceptible to stress) and stress resilience (being able to recover readily from stress), obtain biomarkers (a biological indicator) for stress resilience and to devise strategies for prevention and treatment of stress-related disorders. Read Less
Gender:
ALL
Ages:
Between 18 years and 22 years
Trial Updated:
06/26/2025
Locations: University of Michigan, Ann Arbor, Michigan
University of Michigan, Ann Arbor, Michigan
Conditions: Healthy
Fractionated 1927-nm Non Ablative Thulium Laser in Treating Post Inflammatory Hyperpigmentation
Recruiting
To study the effect of fractionated 1927-nm non ablative thulium laser in reduction of post inflammatory hyperpigmentation (PIH) using a validated and reproducible model for studying PIH.
* Determine if there is aa reduction in PIH in patients treated with three (3) monthly sessions of fractionated 1927-nm non ablative thulium laser
* Determine if there is efficacy of post-procedure clobetasol propionate 0.05% ointment in the management of PIH
* Determine the histological and molecular changes... Read More
To study the effect of fractionated 1927-nm non ablative thulium laser in reduction of post inflammatory hyperpigmentation (PIH) using a validated and reproducible model for studying PIH.
* Determine if there is aa reduction in PIH in patients treated with three (3) monthly sessions of fractionated 1927-nm non ablative thulium laser
* Determine if there is efficacy of post-procedure clobetasol propionate 0.05% ointment in the management of PIH
* Determine the histological and molecular changes that occur with laser and laser plus topical steroid treatment compared to untreated skin Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2025
Locations: Henry Ford Medical Center, Detroit, Michigan
Henry Ford Medical Center, Detroit, Michigan
Conditions: Healthy
Michigan Food and Atopic Dermatitis (M-FAD) Program - Molecular Analytics Project
Recruiting
This study will explore potential links between atopic dermatitis and food allergy. This information will be useful to determine atopic dermatitis and food allergy share unique biochemical or genetic identifiers useful for diagnosing and treatments in the future.
This is a mechanistic study consisting of obtaining blood and skin samples from participants at baseline. Individuals may also undergo a clinically indicated oral food challenge and have blood and skin samples collected at various time... Read More
This study will explore potential links between atopic dermatitis and food allergy. This information will be useful to determine atopic dermatitis and food allergy share unique biochemical or genetic identifiers useful for diagnosing and treatments in the future.
This is a mechanistic study consisting of obtaining blood and skin samples from participants at baseline. Individuals may also undergo a clinically indicated oral food challenge and have blood and skin samples collected at various times during the oral food challenge. This study will create a molecular map of the pathology of atopic dermatitis and food allergy. This information will be deployed to evaluate the hypothesis that atopic dermatitis and food allergy share unique genetic transcriptional signals in which the study team can then further analyze pathological pathways and cell types. Read Less
Gender:
ALL
Ages:
Between 10 years and 55 years
Trial Updated:
09/17/2024
Locations: University of Michigan, Ann Arbor, Michigan
University of Michigan, Ann Arbor, Michigan
Conditions: Atopic Dermatitis, Food Allergy, Healthy
The Impact of Light Exposure on Cognitive Function in Classrooms
Recruiting
Humans are constantly exposed to a variety of light types, created naturally or through artificial means. Light exposure captured by the eyes impacts many physiological functions in humans, including but not limited to cognitive output, fatigue levels, and mood regulation. The level of impact on cognitive learning from different types of light on undergraduate adult students remains unclear.
Humans are constantly exposed to a variety of light types, created naturally or through artificial means. Light exposure captured by the eyes impacts many physiological functions in humans, including but not limited to cognitive output, fatigue levels, and mood regulation. The level of impact on cognitive learning from different types of light on undergraduate adult students remains unclear. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/16/2024
Locations: Michigan State University, East Lansing, Michigan
Michigan State University, East Lansing, Michigan
Conditions: Healthy
A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B)
Recruiting
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamic (PD) of SR604 in healthy participants (Part A) and to evaluate the safety, tolerability, PK, PD, and efficacy of SR604 in participants with Hemophilia A or Hemophilia B, with or without inhibitors (Part B).
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamic (PD) of SR604 in healthy participants (Part A) and to evaluate the safety, tolerability, PK, PD, and efficacy of SR604 in participants with Hemophilia A or Hemophilia B, with or without inhibitors (Part B). Read Less
Gender:
MALE
Ages:
Between 18 years and 60 years
Trial Updated:
07/07/2025
Locations: University of Michigan Hospitals - Michigan Medicine, Ann Arbor, Michigan
University of Michigan Hospitals - Michigan Medicine, Ann Arbor, Michigan
Conditions: Healthy Participants, Hemophilia A, Hemophilia B
Adversity, Brain and Opioid Use Study
Recruiting
The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms. The purpose of this project is to examine brain function and performance during learning and memory tasks in adults. The study will compare measures of learning and memory across three groups of participants: those with an Opioid Use Disorder (OUD) that take buprenorphine for opioid replacement therapy, adults without an Opioid Use Disorder taking buprenorphine, and h... Read More
The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms. The purpose of this project is to examine brain function and performance during learning and memory tasks in adults. The study will compare measures of learning and memory across three groups of participants: those with an Opioid Use Disorder (OUD) that take buprenorphine for opioid replacement therapy, adults without an Opioid Use Disorder taking buprenorphine, and healthy adults that do not have an Opioid Use Disorder and are not taking buprenorphine. Read Less
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
01/09/2025
Locations: University of Michigan, Ann Arbor, Michigan
University of Michigan, Ann Arbor, Michigan
Conditions: Opioid Use Disorder, Healthy
Multifocal HD-tDCS and Motor Function
Recruiting
The purpose of this study is to understand how the brain controls movement and how Non-invasive Brain Stimulation (NIBS) with a technique called High-density transcranial direct current stimulation (HD-tDCS) can alter brain processes to improve behavior. Participants in this study will be randomized to either HD-tDCS with standard intervention or personalized dose-controlled multifocal network-targeted HD-tDCS.
The hypothesis is that dexterous hand function will improve after a standard HD-tDCS... Read More
The purpose of this study is to understand how the brain controls movement and how Non-invasive Brain Stimulation (NIBS) with a technique called High-density transcranial direct current stimulation (HD-tDCS) can alter brain processes to improve behavior. Participants in this study will be randomized to either HD-tDCS with standard intervention or personalized dose-controlled multifocal network-targeted HD-tDCS.
The hypothesis is that dexterous hand function will improve after a standard HD-tDCS dose and increase even more after personalized dose-controlled multifocal network-targeted HD-tDCS. Read Less
Gender:
ALL
Ages:
Between 65 years and 85 years
Trial Updated:
05/30/2025
Locations: University of Michigan, Ann Arbor, Michigan
University of Michigan, Ann Arbor, Michigan
Conditions: Healthy
A Provider Intervention to Reduce Financial Toxicity in Patients With Cancer Through Improved Treatment Cost Discussions
Recruiting
The overall goal of this research program is to address financial toxicity through the development, testing, and implementation of a multi-level communication intervention. If successful, this intervention could be a companion intervention for Cancer providers in combination with the already in testing DISCO app (Discussions of Cost App) for patients. Participants will:
* complete a baseline survey
* attend two one on one meetings, one as part of the development and the second as part of the pi... Read More
The overall goal of this research program is to address financial toxicity through the development, testing, and implementation of a multi-level communication intervention. If successful, this intervention could be a companion intervention for Cancer providers in combination with the already in testing DISCO app (Discussions of Cost App) for patients. Participants will:
* complete a baseline survey
* attend two one on one meetings, one as part of the development and the second as part of the pilot testing of the intervention. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
06/26/2025
Locations: Karmanos Cancer Institute, Detroit, Michigan
Karmanos Cancer Institute, Detroit, Michigan
Conditions: Healthy, Financial Toxicity
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients
Recruiting
This is a dose escalation study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of SIF001, a monoclonal antibody with the potential to treat epilespy
This is a dose escalation study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of SIF001, a monoclonal antibody with the potential to treat epilespy Read Less
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/25/2025
Locations: Quest Research Institute, Farmington Hills, Michigan
Quest Research Institute, Farmington Hills, Michigan
Conditions: Epilepsy, Healthy Volunteer
Medical Discoveries and Innovation in Michigan
The state of Michigan has an excellent reputation for conducting successful clinical research. The trials use superior technology, treatment, and tools to provide patients with the best possible care. Some of the most important medical discoveries made in Michigan include:
- Artificial Heart: Researchers from the University of Michigan helped implant the First Total Artificial Heart in 1988. This is a remarkable milestone in the field of cardiac surgery.
- Multiple Sclerosis Therapies: In 1999, Dr. Sonda Rossman and Howard founded the MIND Multiple Sclerosis Center. It is one of the biggest private comprehensive centers for multiple sclerosis in the country. Their experts have been at the forefront of developing MS treatments and boosting the patient’s quality of life.
- Stem Cell Research: Michigan researchers have made significant contributions to stem cell research. They explore the cell’s potential in regenerative medicine and disease treatment and have made notable progress.
Why Michigan Is A Great Place For Clinical Research
The state has a relatively diverse population. This makes clinical research in Michigan a viable option for better treatment outcomes. According to MI population statistics, 74.2% of its residents are White, 13.8% are Black, 5.6% are Hispanic, 3.4% are Asian, 2.4% are multiracial, and 0.6% are American Indian.