Paid Clinical Trials in San Francisco

Candace Kastanis

Written by Candace Kastanis

Chemistry B.S. | UC Davis | Clinical Lab Technician

Updated & Fact Checked 7/30/26

Research Opportunities in San Francisco

Paid Clinical Trials in Los Angeles

San Francisco research runs overwhelmingly through one institution. As of July 2026, 1,181 studies are actively recruiting in the city, according to ClinicalTrials.gov, and UCSF accounts for the large majority across its several campuses.

Experts say that around 1 out of 200 people in the US need to be continuously involved in medical research of this variety at all times in order to advance the science. What this indicates is that, if you factor in data from San Francisco proper and surrounding areas, you’re looking at some substantial opportunities. San Francisco’s population is 887,711, and the Combined Statistical Area (CSA) surrounding the metropolis is 9,710,000+.

That means there are between 4,438 and 48,550 total opportunities for paid volunteer options through local CROs. Since there are 98 to 700 CROs in this area, that means each CRO has between 45 and 69 individual opportunities per CRO, depending on where you decide to look.

Many who are in San Francisco proper will prefer not to travel extensively according to the realities surrounding traffic. Keep in mind, though, that these stats represent averages. Each CRO commonly needs multiple participants per study, from as few as 2 to as many as 2,000. You can definitely find opportunities. Following we’ll narrow down the data further to help inform your choice.

Quick Facts: Paid Clinical Trials in San Francisco

  • Actively recruiting studies (July 2026): 1,181 (ClinicalTrials.gov)
  • Typical compensation: $50–$100 per completed outpatient visit; residential Phase 1 studies pay more (see highest paid clinical trials)
  • Cost to participate: $0 — study care and visits are covered by the sponsor
  • Worth knowing: Stanford lists Palo Alto and Stanford, not San Francisco — over 900 more studies sit down the peninsula
  • Statewide options: paid clinical trials in California

Where San Francisco trials actually run

We sampled recruiting San Francisco studies on ClinicalTrials.gov in July 2026. The sites running the most trials:

Research siteTrials sampled
UCSF (all campuses)166
UCSF Medical Center, Mission Bay16
UCSF Helen Diller Comprehensive Cancer Center13
Kaiser Permanente San Francisco13
Zuckerberg San Francisco General Hospital12

UCSF spreads its research across Parnassus Heights, Mission Bay, and Zuckerberg San Francisco General, so a UCSF study could be in any of several neighborhoods. Stanford lists Palo Alto and Stanford rather than San Francisco and has more than 900 recruiting studies between those two entries, which is worth checking if you can travel down the peninsula.

Demographic Data Shows Clinical Trial Availability in San Francisco

According to available demographic data, paid clinical trials nearby for healthy volunteers will likely include diverse participants. Locally in San Francisco, whites are 44.87% of the population, Asians are 34.33%, and other races constitute 7.7%. The average age in the region is 38.3. Women are 48.99% of the city, men are 51.01%.

Consent for Use of Stored Patient Specimens for Future Testing
Recruiting
The purpose of this study is to obtain informed consent to use stored human biological materials (HBM) (e.g., blood and other tissues) for future studies that may include genetic testing.
Gender:
ALL
Ages:
All
Trial Updated:
09/20/2024
Locations: Univ of Southern California / LA County USC Med Ctr, Los Angeles, California
Conditions: HIV Infections
Mucopolysaccharidosis I (MPS I) Registry
Recruiting
The Mucopolysaccharidosis I (MPS I) Registry is an ongoing, observational database that tracks the outcomes of patients with MPS I. The data collected by the MPS I Registry will provide information to better characterize the natural history and progression of MPS I as well as the clinical responses of patients receiving enzyme replacement therapy, such as Aldurazyme (Recombinant Human Alpha-L-Iduronidase), or other treatment modalities. The objectives of the Registry are: * To evaluate the lon... Read More
Gender:
ALL
Ages:
All
Trial Updated:
11/19/2024
Locations: Phoenix Children's Hospital- Site Number : 840003, Phoenix, Arizona
Conditions: Mucopolysaccharidosis I (MPS I)
Cellular Aging and Neurobiology of Depression Study
Recruiting
We are conducting an eight week longitudinal study to learn if blood levels of certain naturally occurring compounds and genetic markers differ between patients with depression and healthy adults who are not depressed, and if any such differences relate to memory performance, mood, and neurobiology. We are also interested in how the gut microbiome is affected by antidepressant treatment. We will do this by comparing the unmedicated depressed patients with matched healthy controls at baseline an... Read More
Gender:
ALL
Ages:
Between 21 years and 60 years
Trial Updated:
06/30/2023
Locations: University of California San Francisco, San Francisco, California
Conditions: Major Depressive Disorder
Brain Development Research Program
Recruiting
Dr. Elliott Sherr and his collaborators at University of California, San Francisco (UCSF) are studying the genetic causes of disorders of cognition and epilepsy, in particular disorders of brain development that affect the corpus callosum, such as Aicardi syndrome, as well as two additional brain malformations, polymicrogyria and Dandy-Walker malformation. The goal of the investigators' research is to use a better understanding of the underlying genetic causes as a foundation to develop better t... Read More
Gender:
ALL
Ages:
All
Trial Updated:
10/05/2023
Locations: University of California, San francisco, San Francisco, California
Conditions: Brain Disorders, Aicardi Syndrome
Endovascular Exclusion of Thoracoabdominal And/or Paravisceral Abdominal Aortic Aneurysm
Recruiting
This is a study to assess the safety and effectiveness of endovascular treatment of thoracoabdominal (TAAA) and paravisceral abdominal (PVAAA) aortic aneurysms. The investigational operation involves placing a stent-graft over the aortic aneurysm.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Division of Vascular Surgery, SFVAMC, San Francisco, California +1 locations
Conditions: Thoracoabdominal Aortic Aneurysm, Paravisceral Abdominal Aortic Aneurysm
Branched Aortic Arch Study
Recruiting
This is a study to assess the safety and effectiveness of endovascular treatment of aortic aneurysms involving the proximal aortic arch. The investigational operation involves placing a stent-graft over the aortic aneurysm.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/17/2023
Locations: UCSF Division of Vascular and Endovascular Surgery, San Francisco, California
Conditions: Aortic Aneurysm of the Proximal Arch
Follow-up After Endovascular Repair of Abdominal Aortic Aneurysm
Recruiting
To collect and analyze clinical follow-up data which can be used to assess the safety, efficacy, and durability of endovascular AAA repair with Zenith and Chuter-Gianturco stent-grafts.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/11/2023
Locations: Division of Vascular Surgery, SFVAMC, San Francisco, California +1 locations
Conditions: Abdominal Aortic Aneurysm
Qualification for Cone-Optogenetics
Recruiting
This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.
Gender:
All
Ages:
All
Trial Updated:
01/19/2022
Locations: University of California San Francisco, Department of Ophthalmology, San Francisco, California
Conditions: Retinal Dystrophies
Study to Evaluate The Safety and Efficacy of Balovaptan in Patients With Acute Ischemic Stroke at High Risk of Developing Malignant Brain Edema
Recruiting
This study is designed to evaluate the safety, efficacy, and pharmacokinetics of balovaptan compared with placebo in participants with acute ischemic stroke (AIS) at risk of developing malignant cerebral edema (MCE)
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
04/04/2022
Locations: University of Alabama At Birmingham, Birmingham, Alabama +1 locations
Conditions: Acute Ischemic Stroke
Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer
Recruiting
This is a Phase 3, open-label, randomized, clinical trial evaluating the efficacy and safety of gedatolisib plus fulvestrant with or without palbociclib for the treatment of patients with locally advanced or metastatic HR+/HER2- breast cancer following progression on or after CDK4/6 and aromatase inhibitor therapy. Condition or disease: Breast Cancer Intervention/treatment: Drug: Gedatolisib Drug: Palbociclib Drug: Fulvestrant Drug: Alpelisib Phase 3
Gender:
All
Ages:
18 years and above
Trial Updated:
08/02/2022
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Breast Cancer

Interpreting San Francisco Demographic Information to Find Paid Trials

What this data indicates is that most studies will be aimed at adult white men in their late thirties, followed by adult females in the same category. Keep in mind, though, that for the best results, diversity is often sought in varying paid clinical trials for healthy volunteers. Given the size of the region, you can definitely find options, you might just have to look a little deeper.


San Francisco CROs Healthy Participants Might Explore

To narrow down your search for healthy volunteer paid clinical trials, consider these options in San Francisco proper:

  • SureChem to the North, Near the Docks, East of the Golden Gate Bridge
  • Anresco Laboratories Toward the Bay, East of The Mission District
  • BioAntares to the West, Just South of Golden Gate Park

Medical Trends in San Francisco That Influenced Medical Science

To get an idea of the sort of breakthroughs you can be involved with, consider the following key discoveries that happened right in San Francisco:


The peninsula holds a second large cluster of research that will not show up in a San Francisco search:

  • Palo Alto — about 575 recruiting studies: Stanford Health Care facilities and the Palo Alto VA
  • Stanford — about 343 recruiting studies: the Stanford University School of Medicine campus

Caltrain runs from San Francisco down to Palo Alto, and many studies reimburse travel, so these are realistic options for city residents.

San Francisco Paid Clinical Trial FAQs

  • How much do paid clinical trials pay here?

    Most outpatient studies pay $50–$100 per completed visit, plus travel reimbursement. Residential Phase 1 studies pay considerably more. The exact amount appears in the consent form before you enroll.

  • Where in San Francisco are most trials located?

    UCSF dominates, with research at Parnassus Heights, the Mission Bay campus, and Zuckerberg San Francisco General. Kaiser Permanente and California Pacific Medical Center run additional studies, and Mission Bay in particular hosts many early-phase trials.

  • Should I look at Stanford as well?

    If you can travel down the peninsula, yes. Stanford’s studies list Palo Alto and Stanford as their cities, together accounting for more than 900 recruiting studies. Caltrain runs from San Francisco to Palo Alto, and many studies reimburse travel.

San Francisco CRO Trial Opportunities Healthy Volunteers Might Consider

San Francisco is a leader in technology, and what’s going on in the world right now is a combination of technology and medicine. Think about nano-machines and Big Data. Imagine being networked into an IT grid. San Francisco is leading the way. If you want to be part of history, advance medical science, and get paid, volunteering for paid clinical trials makes a lot of sense.